News | March 13, 2019

Coperion K-Tron To Participate In 'Continuous Manufacturing' Keynote Series At INTERPHEX Conference 2019

Source: Coperion & Coperion K-Tron
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Keynote Series, Innovation Stage, #1281
Tuesday, April 2, 2019

“Designing Continuous Manufacturing Processes for Solid-Dosage: Development to Commercial Scale” - 10:30am - 12:00pm

Several solid-dosage drugs are now approved for manufacture using continuous processes, and early adopters and equipment manufacturers have been making progress in addressing engineering challenges. Two of the potential advantages of continuous manufacturing compared to batch manufacturing are rapid development and flexibility in scale. This panel discussion will consider what benefits are being realized and what challenges are arising as continuous processes are commercialized. Experts will discuss best practices for and challenges in tech transfer and scale-up/scale-out from development to commercial scale.

Moderator: Jennifer Markarian, Manufacturing Editor, Pharmaceutical Technology
Panelist(s): Doug Hausner, Associate Director, Engineering Research Center for Structured Organic Particulate Systems (C-SOPS), Rutgers University; José Luis Santos, Head of Drug Product Continuous Manufacturing, Hovione; Sharon Nowak, Global Business Development Manager, Coperion KTron; Gregory Connelly, Director, Formulation Development and Drug Product Continuous Manufacturing Lead, Vertex Pharmaceuticals

As the pharmaceutical industry continues to accelerate the current paradigm shift in pharmaceutical processing from batch to continuous, Coperion and Coperion K-Tron have continued to be technology leaders in this mode of manufacture. Our high-accuracy loss-in-weight feeders, integrated pneumatic refill systems, and continuous pharma extruders have become critical components of various continuous and semi-continuous processes, such as continuous direct compression, continuous wet and dry granulation and hot melt extrusion, milling and micronization, and continuous coating. Our loss-in-weight feeders, pneumatic systems and extruders are available in hygienic easy clean executions, with options on various modes of product containment, cleaning, and accessibility. Extensive continuous process knowledge, as well as design expertise in handling even the most difficult excipients and active ingredients have made Coperion and Coperion K-Tron the industry leaders in continuous manufacturing technology.

Typical continuous manufacture materials include:

  • API’s (of varied potency levels)
  • Excipients (e.g. microcrystalline cellulose (MCC), hydroxypropylcellulose (HPC), crosscarmellose sodium, lactose hydroxypropylmethyl cellulose (HPMC), silicon dioxide, titanium dioxide, povidone (PVP), crospovidone, starch, etc.)
  • Lubricants (e.g. magnesium stearate, calcium stearate, stearic acid, etc.)
  • Diluents and fillers (e.g. salt, calcium phosphate)
  • Binders (e.g. carnauba wax, corn starch, gelatin, sucrose)
  • Liquid Binders
  • Coloring agents & preservatives (e.g. iron oxide, ferric oxide)
  • Synthetic Polymers (e.g. polyvinylpyrrolidone (PVP), polyethylene glycol (PEG))
  • Glidants (e.g. fumed silica, talc, magnesium carbonate)
  • Sweeteners and flavorings
  • Vitamins and antioxidants
  • Final formulation blends

SOURCE: Coperion & Coperion K-Tron