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Density And Refractive Index Measurement In Pharmaceutical Glycerin Production

Source: Anton Paar USA

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Application Note: Density And Refractive Index Measurement In Pharmaceutical Glycerin Production

Glycerin, also well known as glycerol, has enormous relevance in biology because it is, literally speaking, the backbone of every fat. In industry it is of diverse use: From its appliance in the production of nitroglycerin and plastics to its usage in pure form for personal care products, medicine and food, e.g. softening agent in candy and cakes. In future applications, glycerin could replace other glycols, now used as detergent additives and de-icing fluids, and might be used as feedstock for succinic acid fermentation.

Glycerin, a colorless, odorless, hygroscopic and sweet-tasting viscous liquid, is traditionally a by-product of soap making. Nowadays it is also a by-product of biodiesel production, or might be synthesized out of propylene.

Purification Process
Technical grade glycerin, which is a byproduct from biodiesel production, has to undergo a finishing process before it can be used as glycerin for pharmaceutical purposes or for food. The first step is the removal of methanol. The remaining catalyst, soaps and fatty acids of the biodiesel production process are cleaved, then a neutralization is performed. The purified mixture is concentrated by means of distillation to glycerin with a concentration of min. 99.5%.

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Application Note: Density And Refractive Index Measurement In Pharmaceutical Glycerin Production