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Developments In Laboratory Scale Lyophilization For Purification Laboratories

Source: SP Scientific

By Rob Darrington, Genevac

For many years lyophilisation, or freeze drying, has been used to dry samples in the laboratory. The technique is well researched and has become the method of choice for many researchers with a few samples to dry. Lyophilisation is often preferred because a high level of dryness is achieved with low residual solvent levels, and because of the light, powdery, ‘fluffy’ finish of the sample which enables the sample to be easily removed and weighted out.

However, there are a number of potential drawbacks encountered with the conventional freeze drying apparatus, these include:

  1. Samples must be prepared in a limited range of solvents, normally only water can be used
  2. Volatile organic solvents and their mixtures cannot be used
  3. The process is slow