Poster

Efficient Monoclonal Antibody Aggregate Removal By Hydrophobic Interaction Chromatography (HIC)

Source: Thermo Fisher Scientific

By John J. Li, Orjana Terova, Jessica De Rooij, Alejandro Becerra, and Kelly Flook; Thermo Fisher Scientific

This poster shows the optimization of POROS™ HIC resin-use in high-throughput screening (HTS) and subsequently upscaling in both Bind-Elute (B/E) and Flow-Through (FT) mode. Our study shows that a well-designed process together with a robust resin are key to a successful and efficient mAb polishing process.

Design a more efficient, robust and cost-effective polish step utilizing POROS™ HIC resins as an alternative to the mixed-mode step in the original purification process of a clinical mAb containing >12% aggregates.

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