Enabling Custom Chromatography Solutions For Downstream Processing

By Frank Detmers, Pim Hermans, Jessica de Rooij, Orjana Terova, Jing Zhu, and Scott Zobbi

The manufacture of complex bio-therapeutics, such as activated proteins or closely related product forms, requires novel purification strategies, which may not always exist. Our custom ligand and resin development platforms enable the development of innovative purification resins, providing a solution for challenging downstream processes. Here we present custom downstream processing solutions, developed in close collaboration with our customers, including a case study covering the single step purification of prothrombin.

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