From Cell Culture To Target Protein: Exploring The Benefits Of The 24-Well Filter Plate Workflow

Over the last 5 years, the use of 24-well cell culture plates in laboratory applications has substantially increased. This market segment has expanded at an estimated 14% compound annual growth rate (CAGR)— a pace that is expected to continue in coming years.

The popularity of 1 L benchtop bioreactors has also helped intensify the demand for 24-well filter plates. With their greater throughput, these automated bioreactors have sped up cell culture, enabling researchers to perform process development before selecting a final strain of interest. The 24-well filter plate bridges the gap between laboratories processing high-throughput 96-well plates and those moving up to benchtop reactors. This explosion in the use of 24-well cell culture plates have fueled laboratory interest in migrating to total 24-well filter plate workflows.

Pall Laboratory has met this growing market need with a comprehensive line of AcroPrep™ 24-well filter plates that offers total workflow solutions. The new line incorporates the same membranes found in Pall’s 96-well filter plate formats, making scale-up much easier and less time-consuming. By using the same manufacturer and the same membranes across all filter plate portfolios, Pall envisioned significant savings in processing time, labor, and efficiency. This paper explores Pall’s evaluation of the potential applications for its new AcroPrep 24-well filter plate line, plus the time savings it can achieve in protein purification workflows.