White Paper

Fundamentals Of Spray-Dried Dispersion Technology

Source: Capsugel
amberbroadbentandnathanbennete

By Amber Broadbent, Ph.D., Director of Engineering and Nathan Bennette, Senior Research Chemist, Bend Research, a division of Capsugel Dosage Form Solutions

A common problem statement in the pharmaceutical industry is low oral bioavailability of drug candidates with poor aqueous solubility. The literature suggests that a significant majority of new drug candidates are in the Biopharmaceutics Classification System (BCS) class II and IV space, which includes compounds that are dissolution rate, solubility or permeability limited to absorption, or all three. As portfolios across the industry are increasingly focused on these compounds, the need for enabling technologies continues to grow.