By Manfred Felder, process development manager, Alexanderwerk GmbH, Marcus Becker-Hardt, process engineer, Alexanderwerk GmbH
While some of today’s technologies and processes for tablet making do not lend themselves well to increased efficiency in pharma, others are well-suited for the task. It is drugmakers’ responsibility to learn more about what options are available and how they can use them to improve speed and quality in manufacturing.
In tablet manufacturing, the traditional use of a batch-based wet granulation process presents several issues. They include low equipment utilization, high costs and energy consumption, and burdensome cleaning requirements. An alternative is dry granulation by roller compaction. This continuous process eliminates the challenges of wet granulation and offers maximum productivity in raw material processing. However, to appreciate how roller compaction can benefit manufacturing capacity and efficiency, it is important to first understand the functionality and capability of this technology.