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How To Choose Alkaline Or Acid Pharmaceutical Cleaners

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White Paper: How To Choose Alkaline Or Acid Pharmaceutical Cleaners

A great deal is known about how pH affects aqueous critical cleaning. The first step is for you to identify the residue that needs to be removed and then determine the optimal pH range that will remove it. By understanding the structure, functional groups, molecular polarity, solubility and molecular weight of the residue being removed, it is possible to determine if an alkaline or acidic cleaner would work best for a given cleaning method. In most cases, simply by choosing the correct acidic or alkaline pH range for the type of residue being removed, you will be able to select the correct type of cleaner. On some difficult, water insoluble residues there can be additional benefits to understand how pH can manipulate the electrochemistry of the residue as well as the substrate it is associated with. If the pH of the cleaner chosen can create the same charge on the residue and substrate surface, a beneficial repulsion between the two can occur that can help facilitate the removal of the residue off the substrate's surface.

First let's consider how to select the correct alkaline or acidic pH range for the cleaner with respect to the given residue. Typically, alkaline cleaners are used on oily residues and acidic cleaners are used on inorganic residues. The following table outlines the types of chemical structures found in pharmaceutical residues and indicates if they are best cleaned by acidic or alkaline cleaners. Some residues can be cleaned by either, but will tend to lean toward one pH range for most efficient results. At the top of the table is a list of alkaline, high pH cleaners available from Alconox, Inc. You can choose from cleaners intended for manual/ultrasonic cleaning, or machine/spray CIP cleaning in either powders or liquids and with or without phosphates. At the bottom of the table are the acidic low pH cleaners available from Alconox, Inc. It is important to note that difficult-to-classify residues may require bench-scale cleaning verification studies prior to doing larger scale cleaning trials.

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White Paper: How To Choose Alkaline Or Acid Pharmaceutical Cleaners