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How To Reduce Costly Scale-Up Problems in Solid Dose Manufacturing

Source: Natoli Engineering Company, Inc.
How To Reduce Costly Scale-Up Problems in Solid Dose Manufacturing

By Dr. Charles N. Kettler, Natoli Scientific

When scaling a new drug formulation from the development side of R&D into manufacturing, there is often a reality check with respect to process scaleup and performance of the formulation at production levels. Problems with capping/lamination and sticking/ picking are often first realized when a formulation is introduced to a level of compression required to supply market demand.

Natoli Engineering Company, Inc.