Key Considerations When Scaling Up Media Manufacturing

Matthew Zustiak, Director, Cell Culture Development at Patheon — the contract development and manufacturing organization (CDMO) division of Thermo Fisher Scientific — is keenly aware of the challenges associated with scaling up media manufacturing, and how this can impact process development and process scale-up as a whole.

By working with customers to successfully scale up processes, Matthew has a unique perspective in understanding critical media-related factors to consider throughout this process. We sat down with Matthew to talk about a number of these factors—including the importance of consistent raw materials when transitioning from non-GMP pilot-scale to GMP large-scale media manufacturing, the potential impact of supply chain instability on a process, and the need for a trusted partner.