02.01.23 -- Maximizing Cell Culture Productivity

Cell line development is typically on the critical path of drug development. It’s a complex, labor intensive, and multistep process. Our cell line development platform uses the GOCHO™ host cell line to minimize the risk and timeline to develop high-performing clones suitable for manufacturing.

Identifying some key items about your cell line from the beginning, such as the nutrients it needs over the culture time, the impact of metabolites, and critical osmolality, can help to rapidly design a simple daily feeding regimen to perform a production scale. This article describes a straightforward way to achieve a high-performing fed-batch process.

Increasing the integration of upstream and downstream processing and moving toward increased automation results in greater optimization of process efficiency — a key goal for biopharma production. Learn how several different approaches and technologies can improve the efficiency of upstream processing, including cell line development, process intensification, real-time analytics, and process integration.

Learn more about improving the performance of a scalable AAV process in Xcellerex™ XDR-10 and XDR-200 bioreactors using HyClone™ peak expression medium.

Qualifying two suppliers, increasing capacity, implementing a scorecard methodology for strategic suppliers, and surveying suppliers for their number of production lines are all important ways to guarantee steady supply of materials and technologies — but we must ensure close attention is also paid to raw materials.