Paracetamol Tabletting Properties
In a study, Grace compared SYLOID® 244 FP silica to fumed silica and found that processing, handling, and direct compression were all significantly improved by SYLOID® silica’s higher bulk density and uniform particle size distribution.
A typical formulation containing a model active pharmaceutical ingredient (API), Paracetamol (50%), was evaluated with various formulation parameters as shown in the table above. Blends were prepared with increasing amounts of glidants from 0.5% up to 5%. The porous silica gel, SYLOID® 244FP provided several formulation benefits such as improved powder flow, better tablet properties, and efficient release of APIs.
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