Application Note

Unlock Oral Delivery Potential For Macromolecules With A Parallel Screening Approach

Source: Catalent
redsoftgels

Salmon Calcitonin is a peptide with poor oral bioavailability. To assess its potential for oral delivery, Catalent conducted a parallel screening with 2 different technologies targeting duodenal and sublingual biological barriers respectively. Lipid formulations and lyophilized tablet formulations were developed in parallel. Subsequently, based on the animal PK study data, the optimal  formulation and dose form was identified which shows the oral bioavailability of Salmon Calcitonin was increased by more than 20 times.

VIEW THE APPLICATION NOTE!
Signing up provides unlimited access to:
Signing up provides unlimited access to:
  • Trend and Leadership Articles
  • Case Studies
  • Extensive Product Database
  • Premium Content
HELLO. PLEASE LOG IN. X

Not yet a member of Pharmaceutical Online? Register today.

ACCOUNT SIGN UP X
Please fill in your account details
Login Information
I'm interested in newsletter subscriptions.
ACCOUNT SIGN UP

Subscriptions

Sign up for the newsletter that brings you the industry's latest news, technologies, trends and products.

You might also want to: