bio-techne White Papers
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Use Of Maurice CE-SDS In ICH Q6B-Based Biosimilar Comparability Exercises
11/23/2021
The route to market for biosimilars places strong emphasis on the analytical and characterization techniques used to investigate the structure of the molecule and, importantly, side-by-side comparability.
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Validating Targets For Targeted Protein Degradation Using dTAG – A Comprehensive Workflow Solution
8/19/2021
Degraders and the field of Targeted Protein Degradation offer a mechanistically differentiated way to modulate target proteins using small molecules. TAG degradation technology offers a generalizable strategy to degrade, in principle, any intracellular protein of interest (POI). In this paper we present data to highlight a full dTAG workflow solution, from custom KI cell lines for a protein of interest, to different dTAG Degraders available for treatment and subsequent quantitative characterization using an automated high throughput western blotting platform, Simple Western.
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Organoids: Ideal Model Systems For Disease And Drug Screening?
6/22/2021
Successful organoid formation is dependent on many factors, all of which are crucial in fulfilling the potential of this powerful new tool for personalized medicine.
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Simple Western Advances Cutting-Edge Duchenne Muscular Dystrophy Research
2/4/2021
Duchenne Muscular Dystrophy (DMD) is a severe genetic disease characterized by the progressive breakdown of skeletal and cardiac muscles, resulting in weakness, loss of cardiac function and premature death. The cause of DMD is frameshift mutations to dystrophin, a gene responsible for linking the actin network to transmembrane components of the dystrophin-associated glycoprotein complex (DGC). Dystrophin’s large molecular weight is no problem for Simple Western, a capillary-based immunoassay platform from ProteinSimple.
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Simple Western With Jess Uncovers Possible New Strategy To Prevent And Treat COVID-19
2/4/2021
As the global death toll from the COVID-19 pandemic approaches 1 million, the scientific community has jumped into high gear to understand and treat SARS-CoV-2 infection. It is understood that SARS-CoV-2 entry into host cells involves the binding of the viral spike protein to the human ACE2 receptor. Read more about how Simple Western, the automated Western blot platform from ProteinSimple, can detect and quantify ACE2 and the associated protease TMPRSS2 in human cells.
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Micro-Flow Imaging Enables Cutting Edge Biopharmaceutical Research
1/26/2021
Micro-Flow Imaging (MFI), a system to analyze protein aggregates and other subvisible particles in your samples and can assess the stability of antibody-based biotherapeutics in response to stress