Article
In Vitro And In Vivo Drug Release Of Acetaminophen From New Pregelatinized Starch Based Matrix Tablet
December 2, 2011
In vitro and in vivo drug release of Acetaminophen (APAP) from new pregelatinized starch SWELSTAR™ MX-1 based matrix tablet was investigated. The matrix tablet of MX-1 showed controlled release characteristics in vivo without dose dumping. The sustained drug release profile was confirmed even in lower part of the small intestin where a little digestive juice is available.
It is desirous that in-vivo drug absorption of controlled release (CR) drugs is highly correlated with in-vitro drug dissolution. MX-1 has resistance to ionic strength and mechanical stress, and was expected to achieve high correlation between in-vivo and in-vitro dissolution. It was investigated whether in-vivo drug release properties of MX-1 tablet of zero-order release with polyethylene glycol (PEG) showed controlled release in the same way as in in-vitro using APAP as a model drug.
MX-1 conforms to USP/NE EP and JPE [Pregelatinized Starch] and is launched in 2009 by Asahi Kasei Chemicals Corporation. It was developed by physical modification of potato starch. It performs as a matrix agent to control sustained drug release, and it is applicable for CR of drugs of various water solubility.
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