FEATURE ARTICLES

  • Patient Demand, Vaccines, And Drug Delivery: Q&A With Steve Wick Of 3M Drug Delivery Systems
    Patient Demand, Vaccines, And Drug Delivery: Q&A With Steve Wick Of 3M Drug Delivery Systems

    New technologies are changing the drug delivery approaches used for both small and large molecule manufacturers. Additionally, the more empowered patient is causing many pharma companies to re-evaluate their drug delivery strategies. We spoke with Steve Wick, Senior Technical Director for 3M Drug Delivery Systems, about these topics as well as how the drug delivery landscape might change over the next 5 to 10 years.  

    What technologies are currently changing drug delivery approaches for small molecules? For large molecules? How will these advances impact the pharmaceutical industry?

    For small molecules specifically, I believe that we will see two different trends in drug delivery. The first will be toward the targeting of drug delivery through the use of technology such as nanoparticles or even aptamers. 

  • Shipping With Active Packaging Containers: Three Pre-Flight Decisions That Impact The Success of High-Value Global Shipments
    Shipping With Active Packaging Containers: Three Pre-Flight Decisions That Impact The Success of High-Value Global Shipments

    It is the dead of winter in the northern hemisphere and the height of summer in the southern, with external temperature fluctuations exceeding 50 degrees. Flight delays have added precious days to the transport of your multi-million dollar shipment of blockbuster drug from South East Asia destined for Russia. In France, the roads are closed for days due to a monster snowstorm, with your irreplaceable shipment of investigational drugs stopped somewhere en route between Paris and the clinical trial site. Will all be lost, or can informed choices made before the shipment departs ensure product safety despite unforeseen circumstances?

  • Manufacturing VS. R&D: Round 2 Obtaining Tablet Powder Data for “Flowability”
    Manufacturing VS. R&D: Round 2 Obtaining Tablet Powder Data for “Flowability”

    By Robert G. McGregor, General Manager – Global Marketing, Brookfield Engineering Laboratories, Inc.

    Tablet production depends on steady flow of powder from a feed hopper to the tablet machine. Hang ups are unwelcome because they interrupt production and necessitate a costly restart. Testing the powder for flowability before manufacturing start up is a must in order to prevent this type of problem.

  • 3 Steps To Successful Cold Chain Shipping
    3 Steps To Successful Cold Chain Shipping

    Over the course of time, temperature-sensitive shipping models have become very complex. This is a result of several factors that include an increase in stakeholders, more products in demand of temperature control, and new regulations. As the complexity of the cold chain increases, it becomes more important for everyone involved to make the solutions as consistent and simple as possible.

  • Yield, Creep And Recovery - Why Are They Important?
    Yield, Creep And Recovery - Why Are They Important?

    Material flow behavior may include the phenomenon called “creep” which applies to various liquids and semi-solids, like gels and lotions that continue to move slightly even after placement on the skin. R&D’s intent when formulating the substance is to minimize movement because the medicinal effect is best accomplished by keeping the material in the original position where it is applied. By Robert G. McGregor, General Manager – Global Marketing, Brookfield Engineering Laboratories, Inc.

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PHARMA MANUFACTURING INSIGHTS

  • Hygienic Processing: Elimination Of Dead Space Volume

    Hygienic processing places high demands on the reliability and cleanability of production facilities. These requirements are especially high in separation processes like filtration and chromatography and are significant in ensuring purity of media by maintaining sterile process conditions.

  • The Hidden Value Of Instrument Manufacturers

    For those of you who work with any analytical/lab or process instruments, you know that staying in compliance with global regulations has become burdensome in the past decade. Everyone is fixated on streamlining production processes and reducing the bottom line. This means getting new instruments into the work flow as soon as possible; but to do so you need to know everything there is to know about equipment and instrument qualification. In the overall pharmaceutical manufacturing process, you may be just one cog on the gear of productivity, but without some help, you could go from cog to clog very quickly. By Tara S. Hundley

  • Design Of Experiments For Optimal Production Of Malaria Vaccines

    The aim of a joint project of the HAW Hamburg and the Biomedical Primate Research Center (BPRC) was to identify optimal protein expression conditions for high yields of potential malaria vaccines in the methylotrophic yeast Pichia pastoris.

  • Online Glucose | Lactate measurement In Batch And Fed-Batch CHO Cultivation

    During the cultivation of animal cells the monitoring of nutrients and metabolites has an important role for the controlling strategy of the cell culture.

  • Process Optimization Made Easy: Design Of Experiments With A Multi-Bioreactor System

    Design of experiments (DoE) is one of the most important techniques for systematic planning, execution and statistical evaluation of experiments.

  • 2014 1st Quarter Supply Chain ISAC Report Of Cargo Theft Activity

    In tracking Cargo Theft activity by state as reported to the SC-ISAC in the first quarter of 2014, we see Texas continuing it strong showing by having more incidents than California for the second quarter in a row. The four other states with significant incidents are Georgia, Illinois, Florida and New Jersey.

  • Benefits Of Using ELSD for the Analysis Of Traditional Chinese Medicines

    Traditional Chinese medicines have played an important role in clinical therapy and have been attracting more and more attention for their complementary therapeutic effects to western medicines with low toxicity and few to no complications. With the use of traditional herbal medicines gaining popularity worldwide, the questions of purity and safety of these supplements or natural products have become a concern for public health authorities. The FDA, WHO, and the Chinese Pharmacopoeia have begun generating reliable and accurate analytical techniques to standardize quality control in manufacturing of these supplements to insure the correct identity, authenticity, and lot to lot consistency.

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PHARMACEUTICAL ONLINE VIDEOS

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INDUSTRY NEWS

  • Merck PKU Drug Trial Meets Primary Endpoint

    Merck Serono announced that its Phase IIIB SPARK (Safety Pediatric EfficAcy PhaRmacokinetic with Kuvan) study evaluating Kuvan in children less than 4 years old who have phenylketonuria (PKU) has met its primary endpoint.

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FEATURED SUPPLIERS

  • Walker Barrier Systems
    Walker Barrier Systems

    From custom designed turnkey systems and spare parts/components to full service and maintenance contracts, Walker Barrier Systems has the experience, knowledge, and capabilities to assist in all your Isolation and Containment project needs.

  • Beckman Coulter Life Sciences
    Beckman Coulter Life Sciences

    The integrated resources of Hach help you monitor compliance to pharmaceutical water and cleanroom facility standards. Our world-renowned instrumentation combined with our associates' expertise gives you the confidence to move towards parametric release and process peace of mind.

  • Weiler Engineering, Inc.
    Weiler Engineering, Inc.

    Weiler Engineering is America's leading provider of aseptic Blow/Fill/Seal liquid packaging machines for pharmaceutical and healthcare applications

  • Pall Life Sciences - BioPharmaceuticals
    Pall Life Sciences - BioPharmaceuticals

    The life sciences industry is both driven and united by its need for speed to market, product reliability and economics. Pall Corporation’s leading edge technologies and services play an essential and pivotal role in this industry’s ability to achieve these goals...

INDUSTRY PARTNERS

 

 

LEADERSHIP AWARDS

Life Science Leader developed the CMO and CRO Leadership Awards based on industry leading research conducted by Nice Insight. The awards help pharma and biopharm companies focus on potential partners who can handle their projects and are considered reputable in the industry. Click on the logos above to visit this year’s winners.

 

PHARMACEUTICAL ONLINE SUPPLEMENTS

ABOUT US

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THE FUTURE OF THE PHARMACEUTICAL SUPPLY CHAIN: 2014 RESEARCH REPORT

Implement tools, structures & strategies to create end-to-end visibility, manage global risk & complexity and create a more demand-driven supply chain.

Read The Report...

 UPCOMING TRAINING COURSES

Building Accountability on Your Clinical Teams

April 29, 2014
1pm-2:30pm EDT, Online Training

Root Cause Analysis for Clinical Research Professionals

May 5, 2014
1pm-3pm EDT, Online Training
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LIFE SCIENCE WEBINARS

  • H.R. 3204 Drug Quality And Security Act
    H.R. 3204 Drug Quality And Security Act

    After so many years of struggling with how to comply with the California ePedigree requirement, we now need to know how to comply with the new federal requirement, H.R. 3204. This webinar will review DQSA requirements and timelines.

     

  • PAT-Enabled Process Optimization & Control

    PAT is a risk-based strategy for designing, analyzing and controlling manufacturing processes. The Critical Process Parameters (CPPs) are identified in line with the definition of the Critical Quality Attributes (CQAs) of intermediates or final products. PAT offers a number of tools for measuring and controlling these CPPs.
    Sartorius has the right choice of solutions you need: discover our world of Synchronized PAT Solutions.

  • Adoption of Membrane Chromatography in the Vaccine Industry
    Adoption of Membrane Chromatography in the Vaccine Industry

    This educational webinar will discuss a high throughput process development (HTPD) approach using Mustang® membrane to define the optimal operating conditions resulting in the best quality of the virus product and demonstrate the predictive power of this methodology as applied to the purification of influenza virus.

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ARCHIVE NEWSLETTER

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 PHARMACEUTICAL EVENTS

China: Regulatory Affairs for Pharmaceuticals

April 24 - 25, 2014
Radisson Blu Edwardian Grafton, London

Medical Informatics World 2014

April 28 - 29, 2014
Boston, MA

Strategic Protein Formulation & Drug Delivery

April 28 - 30, 2014
Barcelona

Building Accountability on Your Clinical Teams

April 29, 2014
1pm-2:30pm EDT, Online Training
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TWITTER FEED: @PHARMAONLINE

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