Drought conditions are making it increasingly difficult for pharmaceutical manufacturers to secure the proper wastewater permits in The Golden State.
Sugar is mostly processed as a solution in water to a standardized sugar syrup at 60 to 67 °brix. Different mixing technologies and discontinuous and continuous processes are in use.
Fluid behavior changes with varying amounts of temperature. For instance, if you take a bottle of honey and try to pour the honey out of the bottle at room temperature, the honey appears to be very viscous and would not come out right out of the bottle.
Manufacturing facilities in the pharma industry may set the bar high for complexity and capital density when compared to the wider industrial community. At the very beginning of the design process, however, where the initial concepts are developed and decided upon, all too often a sense of urgency overtakes, leading to shortcuts in the process. However, two factors seem poised to change this pattern.
Delivering safe and efficacious products to patients and care-givers is the healthcare industry's greatest responsibility. The critical path to achieving this and fulfilling our responsibility is embedding quality in everything we do, and more importantly, into the thinking and actions of everyone in the system.
Unconfined yield strength (bulk strength) is the major principle stress that will cause material in an unconfined state to fail in shear. It is the primary flow property that governs the development of hang-ups in process equipment. It is used to compute critical arching and rathole dimensions for a given material in a hopper or bin.
Stepping out of my hotel room on the last day of the 2015 International Society of Pharmaceutical Engineering (ISPE) annual meeting in Philadelphia (November 8 – 11), I reach down and pick up the USA Today that is blocking my egress. Flipping through the newspaper the headline “Allen Always Aimed High” catches my eye. As writer Nicole Auerbach relates how Duke University basketball standout Grayson Allen strived to achieve his childhood dream, I am struck by the similarity between the story and this year’s ISPE annual meeting. “I had so much joy,” recalls Allen of the sensation experienced the first time he successfully slam dunked a basketball on a 10 foot hoop — a goal that took years of persistent practice to finally achieve. It is important to remember that biopharma executives and engineers are not immune to deeply experiencing human emotions (e.g., joy, sorrow). And while attendees of ISPE were certainly treated to high-caliber networking and educational opportunities at this year’s show, they were also provided a strong dose of emotional reality to fuel their passionate pursuit of excellence. Like Duke’s Allen, to achieve beyond your expectations, sometimes it is important to be reminded of why it is you do what you do.
As the FDA continues to compose guidances on the labeling and interchangeability of biosimilar medicines, there remains one big, overarching concern in the industry, and that is making sure biosimilar medicines are not treated as small molecule generics. But should we really be considering the two types of drugs as drastically different as we have been over the past few months?
Last week, Matthew Herper of Forbes published an eye-opening article providing a closer look at FDA approvals in recent years, coming to the conclusion that the industry is facing what could be a dangerously high approval rate for new drugs. But how could high approval rates be a bad thing?
In 2014, Prolong Pharmaceuticals followed through with a decision to build a facility for the scale-up of their lead product, SANGUINATE. As part of this decision, the new facility would not utilize Prolong’s traditional manufacturing process and would instead switch to one that uses single-use technology (SUT) almost exclusively. Chuck Hart, Prolong’s director of manufacturing, recently sat down with me to discuss some areas he feels are sometimes overlooked when switching from traditional stainless steel to SUT.
At this point, it is well known that single-use technology (SUT) can offer many benefits to a manufacturer and their facility. However, there are concerns that single-use technology produces too much harmful waste to achieve sustainability. But is this true?
Ropack Pharma Solutions provides a seamless drug development process for solid oral dosage.
In general, when they talk about risk management, one of the main driving points behind that is that regulators, even our customers, recognize that with the supply chain as it is, it is pretty complex, and there's no way one organization can have total control over the whole chain.
Smart technology as you all know the smart phones are getting more sophisticated and same for the technology to monitor products while they're in transit.
The biggest trends that we see is that in terms of packaging solutions, 120-hours validation time for shipping systems is becoming the industry standard. Anything less is no longer really cutting it. And we also see that the old active container systems are no longer being able to handle this new requirement.
You should consider Custom Powder Systems for your material handling needs. We're much different than other companies that work in the same business. You come to us, we guide you through the process. We customize our equipment to what you need. We just don't sell you model A or model B and hope it works for you; we make sure that it works for you. We go through the details to find what your installation requirements are, what your utilities are and especially the unique things that you don't find off the shelf in places.
When 250+ top-tier pharmaceutical thought leaders get together for 2 days of debate, discussion and discourse, some fur is sure to fly.
Filamatic has been providing solutions for liquid filling applications for over 50 years. Our equipment can be specifically designed to meet your unique needs and expectations. We have built our reputation and kept our customers satisfied by manufacturing equipment that is accommodating, dependable, and precise.
Mettler-Toledo Product Inspection was founded on the premise that it was possible to build a better, more effective metal detector. The year was 1989. Our founders, industry professionals with expertise in metal detection, brought their vision to life and introduced a digital metal detector that was innovative in design and unmatched in sensitivity...
Vaisala, a world leader in environmental measurement, develops, manufactures and markets state-of-the-art relative humidity, dewpoint, carbon dioxide, barometer pressure and meteorological transmitters, hand-held meters and instruments for industrial process, HVAC/EMCS, R&D and OEM applications...
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