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  • How To Boost Profits With Single-Use Powder Transfer In Biopharma
    How To Boost Profits With Single-Use Powder Transfer In Biopharma

    Systems should be analyzed not only for their basic ability to contain the powders of interest, but also for how efficiently they integrate into the production process. For instance, will the system help to eliminate productivity bottlenecks, decrease material waste and the cost of raw materials, and simplify the changeover of the line to new products?

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  • Water For Injection Measurements

    Water is one of the most widely used raw materials in the pharmaceutical plant. Several grades of water are used throughout the plant. One grade, Water for Injection (WFI), is water purified by reverse osmosis or distillation as specified by the United States Pharmacopeia (USP). Specific tests for Conductivity apply to WFI Water produced on site for manufacturing purposes.

  • Tighter pH Control In Chromatography & Purification Systems

    Biopharmaceutical Chromatography Systems are designed for separating and purifying proteins and bio-engineered products. The systems must maintain a hygienic design. Wetted surface finish must be < 20 μinch Ra and material traceability is important to maintain system integrity. pH measurement plays an important role in the purification process, providing feedback control of buffer and effluent feed through the column. The system’s wetted components must withstand Cleaned in Place (CIP) and Steamed in Place (SIP) cycles, which can stress a sensor with high heat and caustic. The pH sensor must be able to make accurate and stable pH measurements after the cleaning cycles.

  • Tighter pH Control In Biopharmaceutical Application

    In fermentation and cell culture, one of the most critical process challenges is to maintain the optimal pH level. Fermentation process utilizes a living organism such as a yeast, bacteria, or fungus strain to produce an active ingredient. Fermentation process is normally shorter in duration (2-7 days). Cell culture is a process in which a mammalian cell is grown to produce the active ingredient. The cell culture process is typically longer (2-8 weeks).

  • Tighter Conductivity Control In Chromatography & Purification Systems

    Conductivity measurement plays an important role in the purification process. Conductivity is one of the determinants of when to start and when to end the collection process. Tighter conductivity controls will increase purity yields. In addition, it may improve secondary collection processing.

  •  Real-Time Viable Particle Monitoring: How Does It Work? How Can It Help?
    Real-Time Viable Particle Monitoring: How Does It Work? How Can It Help?

    For many decades the only practical metric of airborne microbial contamination has been the colony forming unit (cfu). Adapting growth-based approaches for monitoring modern aseptic manufacturing processes has sometimes proven difficult. Although microbiologists have bemoaned the limitations of measuring only cfu, no alternative metric or technique has yet been adopted. In this article we will review one such alternative microbiological method, commonly called laser induced fluorescence (LIF).

  • Integrating New Containment Technologies Into Large Sampling Areas
    Integrating New Containment Technologies Into Large Sampling Areas

    After multiple successful facility projects across the world, Extract Technology were approached by a major Pharmaceutical Company and given the challenge to update the older generation of containment equipment from 1990’s technology to the advanced technology available today.

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Aerosol Microleak Detection System Aerosol Microleak Detection System

Emerson's Cascade Technologies is the global leader of packaging leak detection systems for the Aerosol, Food, and Pharmaceutical industries. The Cascade CT2211 aerosol microleak detection system is the first Quantum Cascade Laser (QCL) system developed for automated, in-line leak detection.

Dual-Input Intelligent Analyzer Instrument Dual-Input Intelligent Analyzer Instrument

Sensor input with an unrestricted choice of dual measurements. This multi-parameter instrument offers a wide range of measurement choices supporting most industrial, commercial, and municipal applications. The modular design allows signal input boards to be field replaced making configuration changes easy. Conveniently, live process values are always displayed during programming and calibration routines.

Conductivity Sensors Conductivity Sensors

The 140 series sensors are available with a range of cell constants, allowing optimum matching of the sensor to the expected conductivity. For low conductivity, choose the 142 sensor (available with either 0.01 or 0.1 / cm cell constants). For moderately high conductivity choose either the 140 or 141 sensors (both available with 0.2 or 1.0 / cm cell constants). The cell constant is accurate to within ±5 % of the nominal value, so the error in the measured conductivity will be at least ±5 %. For higher accuracy, the sensor must be calibrated by the user. A broad range of calibration standards is available.

ENDURANCEā„¢ General Purpose Conductivity Sensors ENDURANCEā„¢ General Purpose Conductivity Sensors

ENDURANCE sensors are metal electrode contacting conductivity sensors. They are available in cell constants of 0.01, 0.1, and 1.0/cm. The choice of cell constant depends on conductivity. High conductivity samples require larger cell constants. Consult the analyzer Product Data Sheet for recommended ranges and accuracy.

Sanitary Flow-Through Toroidal Conductivity Sensor Sanitary Flow-Through Toroidal Conductivity Sensor
The 245 Sanitary Flow-Through Toroidal Conductivity Sensor is intended for use in the pharmaceutical, biopharmaceutical, and food and beverage industries where a conductivity sensor that does not obstruct the process flow is required.
Four-Electrode Conductivity Sensor Four-Electrode Conductivity Sensor
The Model 410VP four-electrode conductivity sensor is intended primarily for the determination of electrolytic conductivity in the pharmaceutical and food and beverage industries. Typical applications include monitoring the concentration of CIP solutions and rinses, monitoring eluents in chromatographic separations, and detecting liquid interfaces.
Dissolved Oxygen, pH, and Conductivity Sensors Dissolved Oxygen, pH, and Conductivity Sensors

This complete line of steam-sterilizable products caters to the most demanding processes used in the Biotechnology, Pharmaceutical, and Food & Beverage industries. Emerson Process Management’s instruments and sensors are ideal for pH, dissolved oxygen, and conductivity measurements for batch processes where steam-in-place sterilization is performed. The high-performance sensors offer a long, stable life while requiring only minimal maintenence. The various mounting accessories have been specifically designed to provide easy sensor access with either fixed weld-in or retractable mounting configurations. All instruments offer a wide variety of features, allowing the user to choose the best analyzer/transmitter for their individual process needs.

Autoclavable and Steam Sterilizable pH Sensors Autoclavable and Steam Sterilizable pH Sensors

Designed for accuracy and stability in a heat intensive application, the new 3800 series pH sensors are optimized for autoclaving and steam sterilization. Building on PERpH-X® and AccuGlass® technology, the 3800 sensors exhibit unparalleled stability after exposure to high temperature sterilization.

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