Guest Column
Powder Characterization Techniques For Wet Granulation Applications
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•Guest Column: Powder Characterization Techniques For Wet Granulation Applications
By Tim Freeman, Freeman Technology
Wet granulation is a routine unit operation within the pharmaceutical industry, and a common precursor to tableting. It is typically carried out as a batch process, with endpoint detection an important issue. Here, dynamic powder rheometry offers proven benefit. By providing sensitive detection of the transition from wet mass to granulate, using a property that is independent of scale, this powerful analytical technique accelerates scale-up and over the longer term improves manufacture.
High shear mixers tend to be the preferred choice for wet granulation. After initial blending of the dry constituents, a solution is added to wet the blend and promote granulation to a desirable endpoint. Control is achieved by manipulating the amount of granulation solution added, the rate of addition, processing time and the impeller speed.
Click Here To Download:•Guest Column: Powder Characterization Techniques For Wet Granulation Applications
