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The Impact Of Dissolution On Particle Size And Particle Shape Of Multi-Component Drug Delivery Systems
By Adam Keith and Peter Bouza, Micromeritics Pharmaceutical Services
The particle size and particle shape of multi-component controlled release drugs must be considered during their dissolution. Though the size and shape of the particles are well known during formulation and manufacture, oftentimes, little is known about the changes in size, shape, and morphology during dissolution. Particles that start as spheres or granules will eventually take new shapes as they break down. Particle shape analysis is used to show that the multiple components of the drug are similar in size but have distinct shapes as well as to demonstrate that particle shapes change as they dissolve.
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