Developing More Clinically Relevant Drug-Induced Thrombosis Models

A breakthrough in studying thrombosis and drug effects on the circulatory system has emerged with the development of the Blood Vessel-Chip. This innovative technology addresses the shortcomings of current pre-clinical models, which struggle to predict drug-induced thrombosis due to the complex nature of blood flow and drug interactions. The chip has notably identified the pro-thrombotic effects of Hu5c8, a compound linked to unexpected thrombotic events in clinical trials. By incorporating human blood samples, the chip offers crucial insights into drug mechanisms and facilitates the testing of anti-platelet and new anti-thrombotic drugs.

Learn more about how this advancement, detailed in Clinical Pharmacology and Therapeutics, showcases the chip's capability to replicate drug side effects and mimic the human circulatory system accurately, enhancing drug safety and efficacy in development.