White Paper

Integrated Technologies To Accelerate Process Intensification For Viral Vaccine Manufacturing

Source: Sartorius

By Piergiuseppe Nestola, Ph.D., Sartorius Stedim Switzerland AG, Tagelswangen, Switzerland

Sartorius

With the increasing world-wide demand for viral-based vaccines (VBVs) which includes attenuated and inactivated viral vaccines, as well as viral vector vaccines to protect against the coronavirus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), faster development times are required to progress VBVs more rapidly into clinical development and then to market. This has meant VBV manufacturing is changing and is being driven by the need for increased speed and greater flexibility. The requirement for greater flexibility has led to new types of manufacturing facilities which can accommodate a growing range of different types of VBVs and can be reconfigured easily to take high clinical trial attrition rates into account. To meet these challenges, vaccine manufacturers, for example those developing SARS-CoV-2 vaccines in cell culture are adopting strategies including process intensification as they believe this will help achieve higher product titers while reducing manufacturing footprint thus making larger numbers of doses of VBVs more readily available. To deliver on this, there is a need for products that can facilitate process intensification and operate under these conditions when manufacturing VBVs. To facilitate process intensification of VBVs including SARS-CoV-2 vaccine candidates, an integrated portfolio of technologies developed by Sartorius is detailed in this article.

access the White Paper!

Get unlimited access to:

Trend and Thought Leadership Articles
Case Studies & White Papers
Extensive Product Database
Members-Only Premium Content
Welcome Back! Please Log In to Continue. X

Enter your credentials below to log in. Not yet a member of Pharmaceutical Online? Subscribe today.

Subscribe to Pharmaceutical Online X

Please enter your email address and create a password to access the full content, Or log in to your account to continue.

or

Subscribe to Pharmaceutical Online