Maintaining sterile process conditions is a vital but daunting task for manufacturers. Separation processes like filtration and chromatography place considerable demands on sterile systems and must be done properly to ensure the purity of media. The consequences of failure are huge.
For customers and regulators, nothing less than perfect purity is acceptable when mixing different media during fermentation. Failure to meet these expectations can prove fatal to a business. On a more mundane level, the use of flawed plant designs affects the lifespan of production equipment, with pipe systems, valve manifolds and tank installations all prone to contamination in pharmaceutical manufacturing.