In-Situ Dissolution Tester

IDS or In situ Dissolution System is about the application of direct measurement technology to Dissolution Testing. Traditionally, dissolution testing has been carried out on solid dosage forms using a standard dissolution tester. Samples of the dissolving active within the dosage form are taken for estimation from the dissolution tester either manually, or using more automated means such as a pump which has been connected to a suitable measurement device, usually a UV Spectrophotometer. Using IDS 1000, not only can the whole process of sample measurement be automated, but can also be self contained, such that there is no need for samples to be pumped out of the dissolution vessels to external measurement facilities such as a spectrometer, because all that is needed for the measurements to be made is contained within the confines of the instrument itself.

How does it work?

In the first instance the introduction of tablets or other dosage forms is as with a conventional dissolution instrument using a synchronous tablet drop magazine. The instrument is started according to the WINDISS 32 Dissolution Software control, but the sampling sequences have been replaced by direct measurement technology within the dissolution vessel itself, with each measurement cycle accomplished in seconds rather than minutes.

The in situ measurement is carried out using fibre opticprobes which are located in the shafts of the dissolution tools, i.e., a paddle or a basket (Apparatus 2 or 1). The fibre optic probe can be removed from the shaft so that various path length inserts can be employed for different active concentrations and extinction coefficient ranges. The fibre optic probe can then be simply reinserted into the tool shaft and the next analysis started.