Biodecontamination Closed Loop System: VHP® M100

Source: STERIS Corporation

vhp m100 biodecontamination

STERIS' VHP® M100 Biodecontamination Systems: Closed Loop provide a flexible, safe, environmentally friendly method of decontamination to small, sealed enclosures. It is the proven technology of vaporized hydrogen peroxide biodecontamination for a variety of appications.

STERIS' VHP® M100 Biodecontamination Systems: Closed Loop provide a flexible, safe, environmentally friendly method of decontamination to small, sealed enclosures. The VHP M100 Small Volume Biodecontamination System is a hydrogen peroxide vapor generator for biodecontamination of clean, dry, sealed enclosures used in medical and biological laboratories. The VHP M100 Biodecontamination System is equally efficient in either closed- or open-loop configurations.

The VHP M100 Biodecontamination System is designed for biodecontamination of clean, dry surfaces in and permanent mounting to sealed Enclosures. The Biodecontamination System can operate independently as a stand-alone machine but may also be operated through interface to external equipment. This interface provides many options, including data communication via communication protocols as well as discrete I/O interfacing.

STERIS VHP M100 Biodecontamination System utilizes Vaprox® Sterilant as a means of achieving dry, low temperature sterilization within sealed enclosures such as isolators and glove boxes. The dry, gaseous process consists of four distinct phases:

  • Dehumidification - Humidity is removed from the enclosure via an integrated desiccant system.
  • Conditioning - Vaprox is rapidly injected and converted into a dry vapor that quickly raises the level of hydrogen peroxide to an effective concentration.
  • Biodecontamination - Hydrogen peroxide vapor concentrations are maintained to provide an effective kill of micro-organisms in the enclosure.
  • Aeration - The generator stops injecting Vaprox and accelerates the breakdown of vapor  


  • Biological safety cabinets
  • Isolators
  • Glove boxes
  • CO2 incubators
  • Pass-through chambers
  • Aseptic Filling


  • Productivity - Provides rapid biodecontamination for small enclosures up to 70ft3.
  • Flexibility - Unit can be mobile or integrated into an isolator or biosafety cabinet.
  • Easy to Validate - GAMP Compliant.
  • Efficacy - The gaseous decontamination process is effective against a wide variety of microorganisms and has a broad range of material compatibility.
  • Green - Provides a non-toxic and environmentally friendly alternative to other decontamination processes. Vaporized Hydrogen Peroxide breaks down to water vapor and Oxygen.


  • Modular unit can be conveniently integrated into isolator or biosafety cabinet
  • AISI 304 Stainless steel enclosure wall and access door construction
  • Easy access design for daily operation, service, and maintenance
  • Now available in mobile configuration for multiple-site biodecontamincation applications requiring PLC features
  • PLC control permits interfacing with existing equipment
  • Custom biodecontamincation cycles
  • Custom cycle parameter selection
  • Cycle alarms for all cycle parameters
  • Security access codes
  • Help screen
  • Battery backup protects cycle memory
  • GAMP software documentation packages available
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