Products and Services

RSS

Click Here To Download:
•Brochure: Bosch Isolation Technology

Bosch is the only equipment company to offer fully integrated Isolator and RABS systems. These systems offer improved aseptic environments over traditional clean room for pharmaceutical filling operations by separating the filling area from the operators. While both systems have a number of similarities, such as glove ports, transfer ports and dedicated HEPA coverage, there are also several notable differences. Isolators have an automated bio-decontamination system and are well suited for long fill campaigns. RABS is an attractive solution for existing clean rooms to improve filling quality and for applications that have higher flexibility requirements. If needed, RABS can be an opened to allow for process intervention, while the isolators must remain closed during operation.

Isolators:
Our isolators are fully enclosed, sealed and pressurized units, with HEPA filtered air supplied in a unidirectional manner to the ISO class 5 interior. Air is re-circulated by returning it to the integrated air handlers though sealed ductwork. Glove ports, sleeves and gloves are secured to the walls using well designed and reliable seals. Pre-sterilized equipment and parts are introduced using aseptic procedures including available built in transfer systems.

Locations for glove ports, transfer systems and other equipment are determined using full-scale system mockups. This ensures the customer is involved in the process and is fully satisfied with the final product. Glove testing using our GloveFIT system can be seamlessly integrated to ensure compliance with regulatory expectations.

The isolator chamber is automatically sanitized using our SafeVAP system. This fully integrated device uses a non-wet process to produce high H2O2 concentrations from a single source. Even distribution of the vapor is ensured using a manifold of sanitary supply piping.

All components of the Bosch isolator systems are fully integrated and designed to work together. We also provide isolator solutions for custom applications where integration is required.

RABS:
Bosch offers complete Restricted Access Barrier Systems (RABS) as another Advanced Aseptic Processing solution. The RABS units that we supply are rigid wall enclosures supplied with HEPA filtered unidirectional air to yield an ISO 5 classified space. All air handling equipment is built into the system. Glove port access for personnel is standard with RABS. Glove ports, sleeves and gloves are secured to the walls using well designed and reliable seals. Pre-sterilized equipment and parts are introduced using aseptic procedures including available built in transfer systems and double door airlocks. Doors on the systems are also designed to be opened as necessary for process interventions.

A variation of RABS that Bosch supplies is Closed RABS. These systems consist of fully sealed chambers for use with toxic or highly potent product applications. Personnel protection can be further assured by using negative pressure within the chamber. Filtration systems in the air return system ensures containment of product that may enter the chamber. Manual spray cleaning and clean-in-place systems are available to remove product before opening the chamber for access. These closed RABS systems also offer all of the same features as our standard RABS units.

Click Here To Download:
•Brochure: Bosch Isolation Technology