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FEATURED ARTICLES

  • The Importance Of Solid Fraction Data In Roller Compaction Operations
    The Importance Of Solid Fraction Data In Roller Compaction Operations

    Roller compaction is a continuous dry granulation process to increase the bulk density and uniformity of powders into free flowing granules used in downstream manufacturing operations. It is a complex procedure due to the diversity of available powder blends and the control and adjustment parameters involved in the process. In pharmaceutical operations, the Roller Compaction process has significant effect on particle size distribution, porosity, flowability in downstream operations, homogeneity, compactability and compressibility of the API, additives/ excipients. These factors influence dissolution profiles, disintegration time, and hardness of the produced solid dosage form.

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PRODUCTS & SERVICES

Gas Displacement Pycnometry System: Accupyc II Gas Displacement Pycnometry System: Accupyc II

Gas pycnometry is recognized as one of the most reliable techniques for obtaining true, absolute, skeletal, and apparent volume and density. The AccuPyc II 1340 Series Pycnometers are fast, fully automatic pycnometers that provide high-speed, high-precision volume measurements and true density calculations on a wide variety of powders, solids, and slurries. The instrument completes most sample analyses in less than three minutes without sacrificing accuracy. After analyses are started with a few keystrokes, data are collected, calculations are performed, and results displayed. A minimal amount of operator attention is required.

Envelope Density Analyzer: GeoPyc® 1365 Envelope Density Analyzer: GeoPyc® 1365

The GeoPyc employs a unique displacement measurement technique that uses Dry Flo, a quasi-fluid composed of small, rigid spheres having a high degree of flow-ability. The sample is placed in a bed of Dry Flo which is agitated and gently consolidated about the sample. The GeoPyc collects the displacement data, performs the calculations, and displays or prints the results. The unit also reports percentage porosity and specific pore volume when absolute density information (density excluding pore and small cavity volume obtained from a Micromeritics AccuPyc II pycnometer) is entered.

Single-lane Blistering, Cartoning, And Serialization Machine: BEC 300 Single-lane Blistering, Cartoning, And Serialization Machine: BEC 300

The BEC 300, manufactured by Uhlmann, is the eighth and newest blister line at Ropack Pharma Solutions. The single-lane unit integrates blistering, cartoning and serialization.

Used Fluid Bed Dryer Granulator: Glatt GPCG PRO 120 Used Fluid Bed Dryer Granulator: Glatt GPCG PRO 120

Used Glatt GPCG PRO 120 fluid bed dryer granulator 316L stainless steel product contact surfaces and 12 bar shock rated. Unit includes a 32" HS Wurster combo insert with expansion chamber. The Wurster chamber designed to handle top spray and dryer capabilities, with additional bottom plates. Unit has a 417 liter working capacity as Wurster. Unit includes three (3) spray guns with feed pump skid with three (3) Cole Palmer peristaltic pumps, 1/3 hp each; Marlow air handling unit, steam heated; WIP system with WIP feed pump skid with manifold, 460 volt; Donaldson Torit dust collector on stand; control panel with Allen Bradley PLC controls; operator HMI panel; Servolift bowl inverter, 1,300 KG max load, 460 volt, serial# 04Y21926/11166.

Quality Management Software for Life Sciences Pharmaceuticals Quality Management Software for Life Sciences Pharmaceuticals

Once your equipment is in tune and your operations ready for execution, maximizing production value requires dogged attention to key product and process quality variables, target values and limits.

Unused Bosch GKF 1400L Capsule Filler Unused Bosch GKF 1400L Capsule Filler

Unused Bosch GKF 1400L liquid capsule filler designed to fill liquid into capsules. The unit, can be converted to powder at additional charge. Unit is set up with 00 change parts, IPK (In-Process Control Scale) system, 180 liter empty capsule feeding unit, and GKF HMI integrated controls. The unit had an FAT in April of 2013.

Praxair ControLyo™ Technology:  Controlling Nucleation In Commercial Lyophilization Praxair ControLyo™ Technology: Controlling Nucleation In Commercial Lyophilization

Praxair’s ControLyo™ technology is a critical, quality driven, cost-saving tool that is becoming the cornerstone of pharmaceutical freeze drying applications. It is a novel and scalable method for controlling nucleation during the freezing step in commercial lyophilization. By introducing a carefully timed depressurization event during the freezing cycle, nucleation will occur simultaneously in all vials. Relying on pressure control, the ControLyo technology is highly adaptable and can be retrofitted to most freeze dryers with minimal impact on established lyophilization protocols. And ControLyo technology does not require any changes to existing drug formulations.

Pharmaceutical Drum Lift: Uni-Hoist HES (Hoist Electric Stationary) Pharmaceutical Drum Lift: Uni-Hoist HES (Hoist Electric Stationary)

The Hanningfield Uni-Hoist HES (Hoist Electric Stationary) is an electrically powered lifting column, with different arm attachments for the handling of IBCs, drums, containers and process machinery (e.g. mills, mixers, vacuum conveyors etc.).

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