pharm-liquid-dose-995x60 pharm-liquid-dose-995x60

WHITE PAPERS & CASE STUDIES

  • Are Yield Stress And Creep Similar?
    Are Yield Stress And Creep Similar?

    By Robert G. McGregor, General Manager, Brookfield Engineering Laboratories, Inc.

    Creep is related to yield stress in the sense that the material starts to flow because the yield stress has been exceeded. The onset of creep behavior occurs only when the yield stress threshold has been crossed. So in this sense, the two are clearly related to one another, but how do pharmaceutical manufacturers anticipate the flow problems related to these parameters?

  • A Mesoporous Silica Carrier Optimized For Liquisolid And Lipid-Based Formulations
    A Mesoporous Silica Carrier Optimized For Liquisolid And Lipid-Based Formulations

    Syloid® XDP silicas are mesoporous, amorphous, silica gel excipients with a unique morphology that create an excellent solid porous carrier for pharmaceutical formulations. The combined adsorption capacity, porosity, particle size, and density provides a tool to create formulations which can expedite manufacturing and improve efficacy of the final dosage form.

  • Enhancing Stability In Nutraceutical Products
    Enhancing Stability In Nutraceutical Products

    Nutraceuticals are natural products that are used to provide medical or physiological benefits.

  • Viscosity Flow Curve Tells All
    Viscosity Flow Curve Tells All

    Characterizing any material for flow behavior involves testing it over a range of shear rates relevant to how it is processed in manufacturing or how it is used by the consumer. Ointments, for example, are used to coat human body parts like skin, lips, finger/toe nails, hair, eyeballs, etc. The coating action is such that the medicinal mixture, once applied to the surface of the object, spreads as it is rubbed into place. Therefore, a relevant viscosity test would employ shear rates that mimic this type of spreading action.

  • Challenges & Opportunities: Encapsulation Of Liquid & Semi-Solid Formulations Into Oral Capsules

    The encapsulation of liquids and semi-solids provides solutions for convenient delivery through improved oral absorption of poorly water-soluble drugs.

  • Automated pH Adjustment In An Intelligent Single-Use Mixing Platform
    Automated pH Adjustment In An Intelligent Single-Use Mixing Platform

    Most pH adjustment process steps in single-use biomanufacturing require manual manipulation of the product and vessel, including off-line sampling, pH measurement, and the addition of acid and base.

More White Papers & Case Studies

PRODUCTS & SERVICES

Emphaze™ AEX Hybrid Purifier

Emphaze™ AEX Hybrid Purifier

The Emphaze Hybrid Purifier is a new single-use clarifying device containing a multi-mechanism all synthetic Q-functional anion exchange media integrated with a fine particle, bioburden reduction membrane. The anion exchange media is comprised of a quaternary amine hydrogel supported by a fine fiber nonwoven scaffold. A combination of 3M technology platforms enables the hyperfunctionalization of a high purity polypropylene nonwoven with a covalently attached, thermally stable, water soluble polymer; the functional polymer accounts for roughly two-thirds of the mass of the anion exchange media. The bioburden reduction membrane is a highly asymmetric, high loading capacity polyamide membrane which has nine zones of decreasing pore size spanning a roughly 20X range and terminating with a 0.2 μm bioburden reduction rated pore size.

Used TL Bosch Vial Filling Line

Used TL Bosch Vial Filling Line

One (1) used TL Bosch Vial Filling Line, Model FSM 2700C. Consists of Bosch In-line Vial Washer, 20-position, 6-head undercarriage wash position alternating air to water, 3-head top wash positions alternating air to water, last position for silicon; with TL Systems Feed system and 3 basins with Waukesha feed pumps; Despatch Depyrogenation Tunnel, approximately 46" wide x 14' long tunnel section, 20' overall length; electrically-heated, 2-zone, 80kw hot zone, 40kw cool zone; 400 C max temp, 350 C max operating temp, 96.2/48.1 amp heaters, 480 volt, with motor VFD controllers.

Flexsafe Single-Use Bags

Flexsafe Single-Use Bags

Standard Flexsafe 2D validation bags made of the new polyethylene S80 film are designed for small scale investigations and for the validation of the Flexsafe bag family. They are available in 150 mL and 500 mL volumes to support end users’ process development and validation testing. Flexsafe bags have been designed by combining material science and a Quality by Design approach to provide outstanding cell growth, robustness and assurance of supply for all process steps of biomanufacture.

Sterile Pharmaceutical Check Valves

Sterile Pharmaceutical Check Valves

Sterile check valve and Strainer: Standard and eccentric, with ball, weld end connection version. Suitable for CIP and SIP.

Sterile Union Hoses

Sterile Union Hoses

Re-usable hose connections designed for use in all hygienic processing applications, Guaranteed crevice free, suitable for CIP and SIP.

Aseptic Sampling Systems

Aseptic Sampling Systems

The asepto sampling system from BBS offers simple and safe sampling possibilities with a syringe.

Sterile Tank Flanges

Sterile Tank Flanges

Tank flanges for sterile orbital or aseptic flanges. Clamp tank flanges for clamp ferrules or aseptic clamps.

Pharmaceutical Sight Glass and Flow Indicators

Pharmaceutical Sight Glass and Flow Indicators

Inline flow indicators with weld end and clamp connection. Guaranteed crevice free, fully traceable wetted materials, traceable seal available on request. Suitable for CIP and SIP. Glass mounted without stress.

More Products & Services