Charged Aerosol Detection (CAD) applies to a broad range of HPLC separations and possesses a number of desirable characteristics for detection and quantitation of various compounds including those without UV absorbing chromophores.
A major advantage for using the TriStar II with the Krypton Option is the ability to measure low surface areas. Although the TriStar II standard nitrogen system can measure surface areas as low as 0.01 m2/g, the Krypton Option enables you to measure areas as low as 0.001 m2/g and provides increased accuracy for materials under 1.0 m2/g. Krypton is also useful for analyzing materials that are difficult to sample or have very low density; pharmaceutical lubricants, for example.
Krypton is an excellent choice for low surface area measurements. At 77 K, nitrogen has a saturation pressure of 760 torr, whereas krypton has a saturation pressure of only 2.5 torr.
An international manufacturer of nutritional products needed to improve its tablet coating process. The OEM-supplied spray bar in use was over-wetting tablets and causing quality defects including picking and sticking problems.