pharm-product-inspection-995x60 pharm-product-inspection-995x60

WHITE PAPERS & CASE STUDIES

  • pH Control In Fermentation Plants

    A typical batch fermentation process starts with sterilization so that all micro-organisms found in the mash and reactor are completely destroyed. The mash is heated in the fermenter or a special cooking vessel by injecting live steam or by means of steam coils set in the vessel. Holding the temperature at 121°C (250°F) for 30 minutes is usually adequate to destroy all living organisms in the mash. However some processes require higher temperatures. As shown in Figure 1, a heating/cooling jacket maintains the temperature of the fermentor.

  • Cost Effective Analytical Solutions Optimize Chromatography & Purification Systems
    Cost Effective Analytical Solutions Optimize Chromatography & Purification Systems

    Biopharmaceutical Chromatography Systems are designed for separating and purifying proteins and bio-engineered products. Flow systems are compact in design to maximize throughput. No dead legs in process pipe can exist since unswept areas are more challenging to completely clean as well as delaying product throughput. The systems must maintain a hygienic design. Wetted surface finish must be < 20 μinch Ra and material traceability is important to maintain system integrity.

  • Automation Slashes pH Maintenance Costs
    Automation Slashes pH Maintenance Costs

    A major multinational pharmaceutical company determined that pH maintenance accounts for 46% of all the field work. Customer wanted to increase pH reliability and eliminate rework/scrap due to poor pH measurements. They also wanted to streamline maintenance practices.

  • Calculating The Total Cost Of Ownership Of Production Line Equipment
    Calculating The Total Cost Of Ownership Of Production Line Equipment

    Investments are the building blocks of a company's future. Planning and implementing them requires strategy and system and decision-makers who know their goals and carry out the implementation according to plan are more successful than those who rely exclusively on their impulses.Meaningful information forms the basis of a good investment decision and it helps to protect the future prosperity of your company. This white paper will help you answer several question regarding the total cost of ownership (TCO) of production line equipment including “have you clarified the foundations of your investment decisions?” and “how do you determine and calculate the return on investment (ROI) time of an investment?”

  • How To Select Critical Control Points For X-Ray Systems
    How To Select Critical Control Points For X-Ray Systems

    Food manufacturers typically install an x-ray inspection system at the end of the production line, although it can be installed at any point during the production process. But, which are the best locations for x-ray inspection? Where are the critical control points to ensure the highest levels of product safety? Should x-ray inspection be at the beginning of the production line, where the raw materials arrive, at some intermediate stage, or at the end of the line before products are shipped out? Or would product safety and quality be better served by installing x-ray systems at more than one critical control point? This white paper addresses these questions to help you understand the most effective locations of critical control points.

  • The Industry’s Shift To 100% Non-Destructive Container Closure Integrity Testing With USP <1207>
    The Industry’s Shift To 100% Non-Destructive Container Closure Integrity Testing With USP <1207>

    In recent years, container closure integrity (CCI) testing has steadily moved up the pharmaceutical manufacturing agenda. Latest research has shown that not only ampoules are prone to CCI defects. Other primary packaging types such as vials, cartridges and syringes equally require thorough testing, especially when filled with lyophilized products. Consequently, the United States Pharmacopeia (USP) has been revising its General Chapter 1207, calling for more quantitative, validated CCI test methods. A significant shift is expected towards non-destructive technologies.

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PRODUCTS & SERVICES

Envelope Density Analyzer: GeoPyc® 1365 Envelope Density Analyzer: GeoPyc® 1365

The GeoPyc employs a unique displacement measurement technique that uses Dry Flo, a quasi-fluid composed of small, rigid spheres having a high degree of flow-ability. The sample is placed in a bed of Dry Flo which is agitated and gently consolidated about the sample. The GeoPyc collects the displacement data, performs the calculations, and displays or prints the results. The unit also reports percentage porosity and specific pore volume when absolute density information (density excluding pore and small cavity volume obtained from a Micromeritics AccuPyc II pycnometer) is entered.

Smart Wireless THUM™ Analyzer Advanced Diagnostics Smart Wireless THUM™ Analyzer Advanced Diagnostics

The Smart Wireless THUM Adapter is an easy way to unleash otherwise “stranded” advanced diagnostics, such as pH slope, reference offset, glass impedance, and reference impedance to enable you to diagnose probe condition.

Advanced Dual-Input Analyzer With Continuous Measurements Advanced Dual-Input Analyzer With Continuous Measurements

The Model 56 advanced dual-input analyzer supports continuous measurement of one or two sensor inputs. The modular design allows signal input boards to be field replaced, making configuration changes easy. The high resolution full-color display gives unsurpassed visibility and functionality for liquid analytical instrumentation.

Aerosol Microleak Detection System Aerosol Microleak Detection System

Emerson's Cascade Technologies is the global leader of packaging leak detection systems for the Aerosol, Food, and Pharmaceutical industries. The Cascade CT2211 aerosol microleak detection system is the first Quantum Cascade Laser (QCL) system developed for automated, in-line leak detection.

Inspection Systems For Packaging With Low Headspace (Sachets, Stick Packs, Pouches) – VeriPac 410 Inspection Systems For Packaging With Low Headspace (Sachets, Stick Packs, Pouches) – VeriPac 410

Multi-cavity blister packs and low head space packaging use a variety of test methods to determine package integrity, with most being destructive, subjective, and unreliable.

Container Closure Integrity Testing Of Lyophilized Vials – VeriPac 455 Container Closure Integrity Testing Of Lyophilized Vials – VeriPac 455

Vacuum Decay Technology Referenced in USP <1207> Chapter

Multi-Cavity Blister Package Inspection  – VeriPac UBV Multi-Cavity Blister Package Inspection – VeriPac UBV

The VeriPac UBV Leak Detection System is a deterministic non-destructive technology designed specifically for multi-cavity blister packs. The VeriPac UBV utilizes volumetric imaging under vacuum to detect the presence and location of leaks. It’s a rapid test requiring no changeover or sample preparation. Operators simply input the number of blister cavities, place the blister pack on the inspection plate and press the START button. Within seconds, the operator sees a definitive pass/fail result, along with a volumetric measurement reading. The location of the defective cavity is presented to the operator with an image of the tested package.

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