Using 100% Headspace Inspection For Characterizing And Optimizing Parenteral Manufacturing Processes
Laser-based headspace analysis provides a rapid nondestructive method for performing trace gas analysis in the headspace of sterile pharmaceutical vials, ampoules, bottles, and syringes.
WHITE PAPERS & CASE STUDIES
Effective Cleaning Of BOD Bottles
Many environmental water/wastewater laboratory professionals are faced with the task of cleaning BOD Bottles. The interiors must be cleaned and rinsed completely to remove any inhibitory residues which may interfere with future tests. As these bottles have constricted necks, hand cleaning is difficult and time consuming. By Miele Professional
Ensuring The Headspace Of A Vial Contains A Specific Gas
When confronted with the task of ensuring that the headspace of a vial contains a customer specified gas there are several options available. However if the evacuation of atmospheric gasses and replacement with a specified gas is critical and must be verified, the challenge requires specialized equipment. By Bosch
When Capsules Fall Apart, Who Is To Blame?
Capsule integrity is a given for established manufacturers with impeccable reputations. Consumers, however, know from experience that not all capsules are made equal. Some can be difficult to extract from the blister pack. Others may have gel caps with cracks or, even worse, ruptures that allow the ingredients to spill out. Is this a manufacturing problem? Or has R&D neglected to implement a fool proof test methodology for evaluating capsule stability? Compression and tension testing offer a technical approach with quantifiable results that can be used to assess capsule performance.
Improving Uptime In Aseptic Processing Of Pharmaceutical Liquids
Maximized uptime, minimized changeover time, and efficient OEE are key factors that have influenced the acceptance of aseptic blow-fill-seal in the packaging of pharmaceutical liquids. By Chuck Reed
Vcaps® Plus Capsules: A New HPMC Capsule For Optimum Formulation Of Pharmaceutical Dosage Forms
Hypromellose (HPMC) capsules were originally formulated with a secondary gelling agent. This agent can delay dissolution in some circumstances and lead to unwanted issues during product development.
Achieving Temperature Requirements for Blister Packaging
When tablets are packaged in blisters, the plastic film must be the right temperature at the right moment: which is no easy task at an output of up to 1,300 blisters per minute. A customer-specific combination for proportional valve, temperature sensor and controller master is using the regulation of cooling water flow. If needed, machine developers can implement 13 parallel-working temperature control circuits. By Dr. Egon Huefner, Bürkert Fluid Control Systems