Today, the trend with vaccine packaging is ready-to-administer single-dose packaging. Whether in the form of prefilled syringes or single-dose twist-off containers, this type of packaging offers safety, convenience, and cost benefits over traditional multidose vials.
In numerous pharma companies, the following problem is being posed: shrinking lot sizes are constantly worsening the ratio of packaging system set-up time to running time. By Dr. Ralph Blum, Mediseal GmbH, Schloss Holte
Two years ago, Elaiapharm undertook the packaging of an important new solid dose product (Cipralex, an antidepressant) to be launched across a large number of international markets. The product itself is an ODT – orally dispersible tablet – formulation packed in child resistant cold form blisters.
At the end of the packaging process, the packaged syringes should meet the requirements for sterile devices in the operating room. Therefore, the finished blisters are autoclaved at 121 °C (2 bar) for 15 minutes. Only minimal deformation of the blisters is tolerated, so that the syringes can be used in the operating room without problems after this thermal treatment.
Volumetric feeding by means of a flowmeter, a method that has become established at Pharmatis, was also implemented in this project; the configuration was taken over by the Mediseal HMI. The feeding system is highly flexible and can be adapted to a wide range of products.
Pharmaceutical producers naturally want to utilize their machine capacities to the fullest in day-to-day business. The key words read efficiency, reliability and flexibility – all in line with the highest safety and cGMP standards. Modern and flexible equipment plays a major role in achieving maximum uptime and high quality in all packaging processes. “We always bear in mind our customer’s demands when developing new equipment or designing tailor-made line concepts. This is why all our machines and components are based on a modular concept,” Ralph Pfister, area sales manager at Bosch Packaging Technology, underlines.
Specializing in sterile manufacturing, Excelvision, based in Annonay, France, provides contract manufacturing services for liquid eye drop plastic vials to numerous companies. However, to increase production and capitalize on additional contract manufacturing opportunities, Excelvision enlised Bosch Packaging Systems AG, based in Beringen, Switzerland, to install a fully automated packaging line. With significantly higher output capabilities, Excelvision expects to increase production by nearly five-fold. The new line also gives the company greater flexibility to meet the diverse requirements of its customers.