There are thousands of drugs licensed for use in the UK as well as many different dosage forms. Packaging these quantities reliably calls for innovative machine technology and optimum process technology. An example is the high performance blister machine from Uhlmann, featuring the fastest cartoner in the world and sophisticated valve terminal technology.
Which parameters must pharmaceutical manufacturers take into account for scale-up? How can Quality by Design be introduced in the development phase?
Counterfeit drugs are an increasing threat to both patients and the pharmaceutical industry worldwide. As a pharmaceutical service provider, Lohmann Therapie Systeme AG operates in a global environment.
Compact and flexible – these are the dominating keywords when it comes to machines for producing and developing parenterals in small batches. If the machine is also supposed to fill pharmaceuticals into different types of packaging, the market does not have that much to offer. This is why the Fraunhofer ITEM and Bosch Packaging Technology developed the filling and closing machine ARF 1010, which is now in operation at Fraunhofer ITEM’s Pharmaceutical Biotechnology Division in Braunschweig, Germany.
Diabetes mellitus is the first non-infectious disease that has taken on the magnitude of a pandemic. For diabetes patients, the independent administration of insulin is now a lot easier. Due to their shape, the pens can not only be transported more conveniently, they can also be applied “en route” without attracting attention.
Robots can carry out pharmaceutical manufacturing tasks faster, more consistently and more cost-effectively than manual labor.
Capsule integrity is a given for established manufacturers with impeccable reputations. Consumers, however, know from experience that not all capsules are made equal. Some can be difficult to extract from the blister pack. Others may have gel caps with cracks or, even worse, ruptures that allow the ingredients to spill out. Is this a manufacturing problem? Or has R&D neglected to implement a fool proof test methodology for evaluating capsule stability? Compression and tension testing offer a technical approach with quantifiable results that can be used to assess capsule performance.