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FEATURED ARTICLES

  • Outsourcing Solid Dose Manufacturing Trends In 2014
    Outsourcing Solid Dose Manufacturing Trends In 2014

    In 2014, the contract manufacturing market for solid dosage forms is anticipated to be $19.6B, representing 58% of the total CMO market value of $33.7B. While the market value percentage for solid dose has been drifting downward — likely related to the shift towards biologics, which are more expensive to develop and manufacture — the propensity to outsource oral solid dosage forms continues to grow modestly.

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WHITE PAPERS & CASE STUDIES

  • Avoid Tablet Production Problems In The Formulation Development Process
    Avoid Tablet Production Problems In The Formulation Development Process

    Compression tooling and tablet press manufacturers are faced with ongoing challenges in the tablet manufacturing environments. Providing support in all aspects of the tablet compression process should be expected from your tooling and tablet press partner. These services should include: press operator training, maintenance/calibration services, quick delivery of replacement parts, tooling, tablet design and powder formulation support.

  • How A Placebo Formulation Is Designed For An Oral Solid Dose Product
    How A Placebo Formulation Is Designed For An Oral Solid Dose Product

    To demonstrate the process by which a placebo formulation was designed for an oral solid dose product that would be dispensed to the patient as a fast-dissolve tablet.  The tablet is added to water and the resulting solution is dosed as a antibiotic mouthwash.   Placebo matching was required not only for the tablet but also for the solution which the patient took.

  • Improving Suspendibility Of A Water-Insoluble API For Oral Suspension
    Improving Suspendibility Of A Water-Insoluble API For Oral Suspension

    To improve the suspendibility of a water- insoluble active pharmaceutical ingredient (API) in a sorbitol- based reconstitutable powder for oral suspension formulation using two novel excipients Sentry™Polyox™WSR N80, NF (polyethylene oxide) and Avicel CL-611® NF (microcrystalline cellulose/carboxymethylcellulose sodium).

  • Comparative Human <em>in-vivo</em> Study And The Impact Of The Dissolution Rate On Bioequivalence
    Comparative Human in-vivo Study And The Impact Of The Dissolution Rate On Bioequivalence

    Rapid and consistent in-vivo drug dissolution is critical for drug absorption. In-vitro dissolutions tests are used to predict in-vivo disintegration and dissolution properties of drug products. The in-vitro disintegration and dissolution times of tablets and capsules can vary significantly based on their composition and processing.

  • Using QbD For Process Optimization Of A Novel Oral Solid Dosage Form
    Using QbD For Process Optimization Of A Novel Oral Solid Dosage Form

    As stated in the International Conference on Harmonisation Harmonised Tripartite Guidance on Pharmaceutical Development, ICH Q8 (R2), “The aim of pharmaceutical development is to design a quality product and its manufacturing process to consistently deliver the intended performance of the product.”1 Several tools are available as guidance issued by FDA such as “Quality Systems Approach to cGMP Manufacturing”2 that includes ideas such as Quality by Design (QbD) in the development process. This guidance, amongst others, lay the framework for expectations of regulatory reviewers in their examination of client submittal documentation.

  • Modular Facility Design: A Cost-Effective Option In The Post-Blockbuster Drug Era
    Modular Facility Design: A Cost-Effective Option In The Post-Blockbuster Drug Era

    The pharmaceutical industry has undergone a sea of change in recent years as manufacturers have adapted to the end of the era of large-volume production of mass-market blockbuster drugs. With firms now focusing in on subpopulations of patients, there is a need for lean, adaptable facilities that can switch quickly between multiple products in multiple formats. Modular facilities can meet this need. While not a panacea, for the right project characteristics, ‘Modularity in Design’ can deliver significant and quantifiable long-term value.

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PRODUCTS & SERVICES

High Performance Tablet Deduster: KD7035 High Performance Tablet Deduster: KD7035

High performance tablet deduster for largest dedusting capacities equipped with the latest technology combined with a metal detector by Ceia or Lock. Tablets are dedusted and conveyed with our unique acceleration control and helix in the most sensitive way.

Tablet Deduster For Research Applications: Model E80-N Tablet Deduster For Research Applications: Model E80-N

Ideal for production of middle-sized charges and research applications.

Diverter For Tablets And Capsules: KV2010 Diverter For Tablets And Capsules: KV2010

Manual 2-way diverter used for continuous filling of containers with tablets or capsules.

Jet Breaker -  Deagglomeration Of Pharmaceutical Powders Jet Breaker - Deagglomeration Of Pharmaceutical Powders

De-agglomeration of powder blocs according to GMP standard.

Pharmaceutical Roller Compactor: PP 150 C Pharmaceutical Roller Compactor: PP 150 C

Compaction and granulation machine for the chemical industry.
The Alexanderwerk PP 150 C is especially designed as a machine which meets the highest requirements and standards of the chemical industry. As the smallest Alexanderwerk model for the chemical sector it provides a roller diameter of 150 mm and a roller width of 75 mm. With a throughput up to 400 kg/h the PP 150 C can be used in a test center, for the research and development as well as for the production.

Powder Recovery Cyclones Powder Recovery Cyclones

When a tablet or capsule is formed, small amounts of excess powder spill onto the die table; this excess powder is usually extracted to a central extraction system.

Capsule Conveying Without Product Contamination Capsule Conveying Without Product Contamination

The 9505 stainless steel pneumatic conveyor is designed for the transfer of empty 00-5 sized capsules. Capsules are emptied into a collection container and dispensed at an adjustable rate into a capsule-filling machine. This unique conveyor uses air power to push the capsules through rigid sanitary piping into a hopper above the capsule-filling machine without damaging the capsules. The Nilfisk product conveying process takes place in perfect hygienic conditions, respecting both the environment and the operators’ health.

Pneumatic Vacuum Conveying Without Product Segregation Pneumatic Vacuum Conveying Without Product Segregation

Pneumatic conveyors move powder and granules from sacks, big bags or other containers to the required location in selected quantities and within the desired time. The Nilfisk product conveying process takes place in perfect hygienic conditions, respecting both the environment and the operators’ health.

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