Containment & Isolation Feature Articles

  1. Restricted Access Barriers vs. Isolators: An Energy Consumption Comparison
    11/18/2015

    Instead of comparing barrier systems solely in terms of investment costs, energy consumption offers another insightful approach – especially as it is in line with the recent trend towards green pharmaceutical manufacturing. Depending on ambient conditions, regulatory- and production-related parameters and the respective air supply systems, the energy consumption of Restricted Access Barrier Systems (RABS) and isolators varies significantly. For instance, isolator systems can save up to 65 percent of energy compared with RABS, while active RABS are up to 30 percent more energy-efficient than passive RABS.

  2. Aseptic Production Automation To Reduce Risk And Cost
    10/21/2015

    The use of robotics and automation in the industry is not new. For several decades now, many assembly lines have utilized production robots in different functions to increase productivity. Although human operators result in a potentially risky activity in sterile areas, pharma manufacturing remains heavily human. This article discusses how to apply current isolation technologies with robotic systems to reduce the risk of microbial contamination in aseptic processes caused by human intervention.

  3. Increase In HPAPI Manufacturing Highlights Need For Containment And Isolation Systems
    7/21/2015

    An estimated 25 percent of globally manufactured drugs contain highly potent active pharmaceutical ingredients (HPAPIs). HPAPI drugs, which include small-molecule and biologic compounds as well as antibodydrug conjugates (ADCs), are often used in the treatment of cancer. The fastest growing segment of the HPAPI market are ADCs, a new class of therapeutic agents that deliver cytotoxic drugs selectively to antigen-expressing tumor cells. Non-oncology HPAPI compounds include hormones, narcotics, and retinoids.

  4. FAQ's: Regulated Films For Containment Solutions
    9/11/2014

    At ILC Dover, we are always "creating what’s next" by listening carefully to our customers. In response to customer input and emerging regulations, we've developed a robust new film to support our DoverPac® Containment Solutions line. This revolutionary product, ArmorFlex® 110, delivers permanent static dissipative properties while meeting FDA and 2002/72/EC requirements for food contact.

  5. ILC Dover Verifies That DoverPac™ Flexible Containment Systems Are Compliant With REACH
    5/5/2009
    As the leader in flexible containment and disposable cGMP systems, ILC Dover, with the assistance of an independent third party consultant, has reviewed the products they offer to the pharmaceutical industry with regard to the REACH regulation.
  6. Article: Test Area Validation And Flexible Containment System Performance: Testing To The SMEPAC 2005 Guidelines
    3/26/2008
    Article: Test Area Validation And Flexible Containment System Performance: Testing To The SMEPAC 2005 Guidelines
  7. A Novel Design To Contained Transfer Of Drummed Materials Using A Disposable Manufacturing Approach
    4/20/2007

    The Drum Transfer System (DTS) described in this article has been validated in a variety of processes requiring the contained transfer of drummed materials in pharmaceutical applications. Processing operations described here include milling, subdividing, charging, and repackaging. Submitted by ILC Dover

  8. The Answer To Final Pack Off Containment
    2/27/2007
    The DoverPac® continuous liner system provides the advantage of replacing packs without breaking containment, unlike using inflatable heads or having operators shuffle tube stock.
  9. Flexible Solutions Broaden Containment Options By Alan E. George, ILC Dover
    2/27/2007

    With the ever-increasing demand for advanced powder containment solutions, flexible containment options and hybrid flexible/rigid solutions are offering process engineers more choices than ever before. Submitted

     

  10. Tips For Optimal Pipetting Results

    By Melissa Winters, Filtration and Ultrafiltration, Liquid Handling, Sartorius Corporation

    There are several environmental factors to be aware of when pipetting. They can all lead to inconsistencies in your results. Be aware of the temperature and humidity levels in the room. The smaller the difference in temperature between the pipette, tip and liquids, the more accurate the results. Evaporation of the liquid can be eliminated by humid air; dry air can cause sample evaporation.