Lighthouse Case Studies
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Container Closure Integrity Testing For Sterile Vial Products In Deep Cold Storage
12/28/2018
During QC testing, a number of vials of liquid vaccine product stored at -80°C were found to have an overpressure, representing a serious safety risk and they needed to identify the root cause.
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Determination Of Moisture Permeation During Product Shelf Life
12/27/2018
How non-destructive headspace analysis information can be critical for QC groups performing stability studies, or for packaging development groups responsible for choosing the optimal packaging.
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Lyo Chamber Moisture Mapping
12/27/2018
Rapid non-destructive headspace moisture analysis from LIGHTHOUSE enables fast moisture determination of statistical numbers of lyo samples.
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Root Cause Investigation Into A Possible Container Closure Integrity Failure
12/27/2018
In cases where oxidation of the formulation causes discoloration and eventual degradation of the product, non-destructive headspace analysis tests can give deep insight into the root cause. Since the samples are not destroyed by the headspace analysis, further testing can be done to accurately correlate headspace conditions with other product characteristics.
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100% Container Closure Inspection Of Freeze Dried Drug Product In Quarantine
12/26/2018
A leading contract manufacturer approached LIGHTHOUSE for help after a suspected raised stopper issue motivated the manufacturer to place several batches into quarantine. A decision was made to perform 100% container closure inspection of the product vials with the help of LIGHTHOUSE.