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FEATURED ARTICLES

  • Merck’s Path To Continuous Manufacturing For Solid Oral Dose Products: What Stands In The Way?
    Merck’s Path To Continuous Manufacturing For Solid Oral Dose Products: What Stands In The Way?

    As the evolution of the global pharmaceutical industry continues to drive the need for more flexibility and lower costs, continuous manufacturing becomes an even more appealing and sensible option. However, despite the tremendous promise of its economic and quality control benefits, there are still many concerns about the regulatory landscape for continuous manufacturing. Dr. Christine Moore, executive director and global head of chemistry, manufacturing and control (CMC) policy at Merck, recently discussed the company’s pursuit of worldwide approval of continuous manufacturing for solid oral dosage products and what regulatory risks it sees as potential roadblocks.

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WHITE PAPERS & CASE STUDIES

  • Avoid Tablet Production Problems In The Formulation Development Process
    Avoid Tablet Production Problems In The Formulation Development Process

    Compression tooling and tablet press manufacturers are faced with ongoing challenges in the tablet manufacturing environments. Providing support in all aspects of the tablet compression process should be expected from your tooling and tablet press partner. These services should include: press operator training, maintenance/calibration services, quick delivery of replacement parts, tooling, tablet design and powder formulation support.

  • How A Placebo Formulation Is Designed For An Oral Solid Dose Product
    How A Placebo Formulation Is Designed For An Oral Solid Dose Product

    To demonstrate the process by which a placebo formulation was designed for an oral solid dose product that would be dispensed to the patient as a fast-dissolve tablet.  The tablet is added to water and the resulting solution is dosed as a antibiotic mouthwash.   Placebo matching was required not only for the tablet but also for the solution which the patient took.

  • Comparative Human <em>in-vivo</em> Study And The Impact Of The Dissolution Rate On Bioequivalence
    Comparative Human in-vivo Study And The Impact Of The Dissolution Rate On Bioequivalence

    Rapid and consistent in-vivo drug dissolution is critical for drug absorption. In-vitro dissolutions tests are used to predict in-vivo disintegration and dissolution properties of drug products. The in-vitro disintegration and dissolution times of tablets and capsules can vary significantly based on their composition and processing.

  • Case Study: Bag Handling, Check Sieving, Weigh System
    Case Study: Bag Handling, Check Sieving, Weigh System

    In this installation, materials are received in 50-pound bags and semi-bulk bags and are security screened for foreign objects while being conveyed to a weigh hopper, where they are automatically hatched in predetermined weights and discharged into process drums.

  • Medication Errors -- A Threat To Patient Safety: Mitigating Errors With Tablet Appearance
    Medication Errors -- A Threat To Patient Safety: Mitigating Errors With Tablet Appearance

    Medical prescription drug errors by doctors, pharmacists and patients account for 1.5 million incidences of sickness, injuries or deaths in the U.S. each year. By Jay Anbil and Steve Yoder 

  • Film Coating For Pediatric Oral Solid Dosage Forms
    Film Coating For Pediatric Oral Solid Dosage Forms

    From a recent survey conducted within the pharmaceutical industry, by Colorcon, it was confirmed that oral solid dosage forms are a preferred choice for formulation of pediatric medicines.

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PRODUCTS & SERVICES

Powder Recovery Cyclones Powder Recovery Cyclones

When a tablet or capsule is formed, small amounts of excess powder spill onto the die table; this excess powder is usually extracted to a central extraction system.

Capsule Conveying Without Product Contamination Capsule Conveying Without Product Contamination

The 9505 stainless steel pneumatic conveyor is designed for the transfer of empty 00-5 sized capsules. Capsules are emptied into a collection container and dispensed at an adjustable rate into a capsule-filling machine. This unique conveyor uses air power to push the capsules through rigid sanitary piping into a hopper above the capsule-filling machine without damaging the capsules. The Nilfisk product conveying process takes place in perfect hygienic conditions, respecting both the environment and the operators’ health.

Pneumatic Vacuum Conveying Without Product Segregation Pneumatic Vacuum Conveying Without Product Segregation

Pneumatic conveyors move powder and granules from sacks, big bags or other containers to the required location in selected quantities and within the desired time. The Nilfisk product conveying process takes place in perfect hygienic conditions, respecting both the environment and the operators’ health.

Pharmaceutical Manufacturing For Commercial Drug Product Pharmaceutical Manufacturing For Commercial Drug Product

With Metrics Contract Services’ extensive capabilities, you can keep your drug product development, clinical trial materials and commercial manufacturing all under one roof. From teacup-size batches and up, Metrics Contract Services provides high quality drug product contract manufacturing for both clinical trial materials and commercialization.

Used OHara Pharma Coating Pan Used OHara Pharma Coating Pan

One (1) Unused O'Hara LabCoat bench top coating pan, model LABCOAT BT, 316 stainless steel product contact surfaces, with 8.5" perforated pan with plenums, spray guns with Watson Marlow peristaltic pump system, on board air handling system rated 40-100 cfm, electrically heated, Siemens controls with model S7 1200 plc and model TP 177B HMI panel, 220 volt, 1 phase, 60 hertz, built 2015, with 1 year factory warranty for parts only.

Pharmaceutical Homogenizer Pharmaceutical Homogenizer

The homogenizer is working as a particles size reducer for particles in suspension in a liquid and to calibrate their size at a defined value.

Pharmaceutical Sampling Valves Pharmaceutical Sampling Valves

A manual or automatic sampling valve can be adapted at the hopper or container powder outlet with a standard containment or bottle system.

Pharma Pneumatic Conveyor for Powders or Granules Pharma Pneumatic Conveyor for Powders or Granules

The pneumatic POSITIVE pressure conveying (or PRESSURE conveying) is dedicated  to the transfer of larger quantities of powder or granulates under following conditions:

Products & Services