Article: 30 Years Isolator Technology

Production of sterile forms in the pharmaceutical industry: From the ancient times of the clean rooms to today's appropriate solutions for the production of the product and the operator at optimal conditions considering the investments and the running costs

For the production of sterile forms, mostly injectables, in the Pharmaceutical Industry, a new step forward into increased product safety began at the end of the sixties and the beginning of the seventies of the last century. The magic word of this step was "clean rooms". Clean rooms were intended to solve all the problems of the old way of producing sterile products with unsterile products and unclean production areas, as yet unstable steam sterilization cycles including problems in microbiological labs, etc. This was the time of full laminar flow ceilings in production rooms, with specially gowned operators entering the critical areas through double step pass-throughs. These rooms took up significant space within the buildings.