INSIGHTS ON LIQUID DOSE MANUFACTURING

• Headspace Oxygen Monitoring On A Pre-filled Syringe Line Filling Oxygen-Sensitive Product

  This application note describes how laser-based headspace analysis is used for the rapid non-destructive determination of headspace oxygen levels in pre-filled syringes. Data is presented demonstrating two major applications of this technique: 1) headspace oxygen monitoring on a pre-filled syringe line filling oxygen-sensitive product, and 2) container closure testing of pre-filled syringes.

• Choose The Right Inline High-Shear Mixer For Your Process

  This white paper presents some ideas for selecting the right inline high shear mixer for your process based on a company’s collective experience as a mixing equipment provider to process industries.

• Equipment Capability Of Freeze-Dryers And Its Relevance To The Graphical Design Space For Primary Drying

  The capabilities of a freeze dryer can change with differences in design. This is particularly important when users are transferring cycles from lab-scale to commercial-scale freeze dryers. Each freeze dryer has its own limitations and it is important to understand these limitations to avoid the risk of product failure when scaling-up the production. This article summarizes a recent webinar discussing how to measure and compare equipment capabilities of lab-scale and production scale freeze dryers in order to define optimal design space parameters.

• Optimizing Filling Technology To Minimize API Loss

  New advances in filling technology offer solutions that can minimize lost API and eliminate sources of risk while still meeting the regulatory requirements for testing and quality assurance.

• Avoiding Hemolysis Blood Sample Collection Processing

  Erythrocytes have significant value in specific types of research. If your objective is biobanking these cells in an intact state then it is equally important that hemolysis and the need for a re-draw is avoided.

• Selecting The Best Pharmaceutical Mixing Equipment For Your Operations

  Finding the right mixing equipment isn’t as simple as selecting an item from a menu. This article is a guide to considerations when choosing pharmaceutical mixing equipment and vendors for a facility.

• Using Positive Controls In Container Closure Integrity Studies

  This webinar describes the use of positive controls as an important element of CCI studies designed to validate packaging components for CCI or to qualify processes for producing good CCI.

• Robotics, Isolators & Restricted Access Barrier Systems (RABS)

  The aim of advanced aseptic processing is the elimination and absolute control of all sources of contaminations - most importantly, human generated contamination. Robotics and isolator-barrier systems will be the core technologies in meeting this endeavor.

• Non-Invasive Headspace Analysis For Automated Media Fill Microbial Inspection

  Laser-based headspace provides yet another alternative approach for detecting microbial contamination in sterile pharmaceutical product allows for quicker, more sensitive, accurate, and reproducible test results when compared with conventional, growth-based methods.