INSIGHTS ON LIQUID DOSE MANUFACTURING

• Automatic Cap Welding Machine For Large Volume Parenteral Bottles

  Weiler Engineering Inc. presents an example of our Automatic Cap Welding Machine for welding Euro, Inso etc. style caps to LVP bottles. The video features 500mL LVP Bottles of LDPE resin produced on our Model 640 Blow/Fill/Seal system.

• Robotic Aseptic Processing For Filling Ready-To-Use (RTU) Vials, Syringes And Cartridges

  As patient treatments move away from broad population therapies in favor of the targeted treatment of smaller (personalized) patient populations, the biopharmaceutical industry is transitioning to smaller aseptic batch manufacturing processes. Robotic solutions provide pharmaceutical manufacturers with a faster, more flexible and cost-effective way to fill different container formats using the same filling platform, responding to the growing demand for small batches, customized packaging, rapid product and format changeovers along with a less user intervention during the filling process.

• CRO, CDMO And Those Using Both — Which Customer Segments Were More Affected By COVID-19 And Why?

  We conducted a blind and independent “voice of the customer” industry survey to ascertain what impact COVID-19 had and was continuing to have on outsourcing decisions for those who sought CRO, CDMO, or both CRO and CDMO services in the global pharmaceutical industry. In part three of our series, we investigate the impacts on different customer segments within pharma and biotech client companies: those who sought to outsource only CRO services; those who sought to outsource only CDMO services; and those who sought to outsource both CRO and CDMO services.

• Freeze-Drying COVID-19 Diagnostics: Formulation & Process Development And Lyophilizer Selection

  Lyophilization may be considered a relatively gentle drying process, but there are still risks and pitfalls when applying it to biomolecular reagents in diagnostic tests that are different to the freeze-drying of general pharmaceuticals. Reagents typically used in ELISA and PCR based diagnostic kits for diseases, such as COVID-19 tend to contain labile  components, such as enzymes that need preserving for longevity in the supply chain or antibodies to test for a patients response to the virus, which can be challenging to stabilize for commercial use. This article summarizes a recent webinar exploring various aspects of formulation and cycle development in the lyophilization of diagnostic reagents, including those required for COVID-19 testing that may be different to regular diagnostics.

• Myth Busting: Misconceptions In Lyophilization

  Several assumptions based on previous knowledge or experience regarding lyophilization are often made but as with many techniques that have become well-developed over time, there remains a number of misconceptions that persist in this process. This tech note summarizes both webinars and includes a selection of questions from the Q&A sessions from a two-part series of webinars questioning ten assumptions that are made when developing the freezedrying process for pharmaceutical products and how these may be counteracted.

• The Advantages Of Robotics In Aseptic Fill Finish

  As you move into a future of diverse pipelines that present both great opportunities and challenges, consider utilizing a flexible solution like robotics that can be rapidly implemented into your facility.

• Orphan Drugs: Balancing Financial Incentives & Complex Challenges

  Orphan drugs are notorious for their high costs and risk factors, which is attributed to smaller patient pools and higher development and launch costs. Despite the niche, high risk market, orphan drugs are on the rise because of the financial incentives and benefits companies are receiving for new drug development. Whether your orphan drug is a small or large molecule, there are key strategies that you can adopt to enable a seamlessly transition from early development into commercial manufacturing, while also balancing your investment.

• Bringing Next-Generation Wearable Drug Delivery Solutions To Market

  A collaboration has been founded on the principal aim of bringing to market wearable injection solutions for the simple and efficient subcutaneous administration of large-volume and high-viscosity medications that serve the interests of both patients and pharmaceutical companies.

• Selection Criteria For Ribbon, Vertical, Or Tumble Blenders

  Among solid-solid blending systems, the three most common types are the horizontal ribbon blender, the cone screw vertical blender and the tumble blender. Aside from level of shear or ‘gentleness’, other factors help determine which type of blender will work most efficiently in a certain application. Following are some things to consider when choosing your blender.