A rapid, flexible, and high-yield approach for both hybridoma expansion and for antibody production using a serum-free medium in Nunc PETG Roller Bottles.
Many existing research labs, pharmaceutical and biopharmaceutical manufacturers, and contract manufacturing organizations (CMO’s) are not designed nor are they equipped with the engineering controls to safely handle the manufacture of ADC’s. The safe manufacture of ADC’s requires more modern facilities, equipment, and engineering controls as well as programs, practices, and procedures to adequately protect the operators and the work environment. Read the steps that must be taken to consider a glovebox workstation fully validated to manufacture ADCs safely.
This white paper explores eight considerations in detail and could be helpful to EHS managers and supervisors looking to select a Powered Air-Purifying Respirator system for their particular application.
Aseptic blow-fill-seal systems for packaging pharmaceutical liquids incorporate materials and process that provide critical advantages for sustainable initiatives.
A collaborative study with a new customer with the objective of taking an existing, smaller preclinical E. coli process previously performed in stainless-steel vessels and scaling it up quickly.
Drug manufacturers seeking alternative methods for a safe and reliable approach to drug delivery should consider blow-fill-seal technology, as it offers several benefits over traditional glass packaging.
A non-invasive, non-subjective solution that is capable of detecting package leaks and invisible defects using a differential pressure transducer leak test system.
Learn how rapid, nondestructive laser-based headspace analysis can support with data generation to demonstrate the maintenance of seal integrity during deep cold storage and transport.
A leading contract manufacturer approached LIGHTHOUSE for help after a suspected raised stopper issue motivated the manufacturer to place several batches into quarantine. A decision was made to perform 100% container closure inspection of the product vials with the help of LIGHTHOUSE.
Used Groninger plastic bottle filling line, consisting of Groninger orienter and feeder, model ZVB 850, with (2) bottle vibrating sorting bowls with independent feed hoppers, serial# 6911, Groninger inline intermittent motion filler, model DMK 8001, walking beam bottle indication, (8) head filling station with independent mass flow meters per filling head with buffer tank, bottle deionization station, bottle blow-out and aspirating station, currently set up for 45 mm diameter x 35 - 200 mm high bottle, 2 - 15 ml fill capacity, serial# 6912, integrated Groninger CIP/SIP system, serial# 6913, Groninger dropper inserter, model KVK 112 A with bowl feeder and dropper verification system, serial# 6914, Groninger capping and torquing unit, model KVK 108, with bowl feeder and cap verification system, serial# 6915, reject, Siemens S7 plc controls with Siemens MP370 HMI. Line currently set up for 3 ml plastic bottles up to 13200/hr. 230/400 volt, 50 hertz, 3 phase, mounted in RABS unit. Line built 2007.
The In-VitroCell™ ES (Energy Saver) model NU-8600 is a CO2 Incubator that uses heated water that surrounds the growth chamber to created uniform temperature conditions for cell culture growth. Water Jacket model NU-8600 also uses an IR sensor to maintain proper CO2 gas levels and produces a humidified environment up to 95% perfect for mammalian cell studies.
The In-VitroCell ES NU-5831 Direct Heat Hypoxic CO2 Incubator can lower oxygen levels in the growth chamber down to 0.5% accurate with in ±0.25% through the use of a Zirconia Ceramic O2 Sensor.
The Sentinel XT™ PAPR (Powered Air-Purifying Respirator) system from ILC Dover offers distinct advantages over hooded PAPRs from other manufacturers. All of these help those who wear the Sentinel XT system enjoy better visibility, more comfort, greater safety and higher productivity.
Model NU-5700 is a CO2 Incubator uses direct heating elements that surround the growth chamber to maintain set point temperature. Model NU-5700 comes standard with a dual wave infrared (IR) sensor to control CO2 gas levels creating optimal growth conditions at or near body temperature.