INSIGHTS ON LIQUID DOSE MANUFACTURING
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Consistent, Reliable, High-Quality Components
Discover a premium line of components for vials, prefilled syringes, and cartridge systems developed and refined to provide best-in-class levels of quality, performance, and risk mitigation.
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Afton Scientific Capabilities Update January 2026: Fill/Finish
Here, Michael Dunn outlines our current available capacity, including RABS operations, alongside the commissioning of a new Annex 1–compliant isolator filling line and expanded QC capabilities to ensure reliable, scalable execution.
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The Journey Of A CDMO Choosing Pre-Sterilized Drug Containers
Explore innovation in pharmaceutical manufacturing with advanced drug containment, delivery systems, and automation, ensuring quality, safety, and efficiency in injectable therapies for global healthcare.
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Barrel Filling Vs. Tip Filling A Syringe – Which Approach Should Be Used?
There are two primary filling methods for pre-filled syringes. Explore the pros and cons of each approach, highlighting why barrel filling is generally preferred in the pharmaceutical industry.
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Innovation In Filtration3/18/2025
Filtration removes contaminants to ensure safety and is essential in various applications, from lab-scale tasks to GMP production. Explore how its simplicity and reliability make it indispensable.
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Generate CHO-K1 GFP-Expressing Cells For Cell Line Development Workflow11/7/2025
Discover a high-efficiency workflow for generating GFP-expressing CHO-K1 clones using automated single-cell dispensing to achieve 93% isolation success and stable expression in under five weeks.
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Navigating The New USP Chapter <382> For Elastomeric Closures6/24/2025
Dive into the scope of <382> for pharmaceutical closures and the regulatory landscape, which includes new required tests, instrumentation for compliance, and recommendations on implementation.
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Ensure Sterility In Small-Batch Drug Production1/9/2026
Automation and sterility are critical for small-batch drug manufacturing. Learn how robotic isolators streamline vial filling, reduce contamination risk, and support advanced therapies with precision.
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Start With An Integrated, Verified PFS System5/21/2026
Synchrony S1 PFS system delivers an integrated, verified solution designed to streamline submissions, support reliable supply, and reduce development risk.
LIQUID DOSE MANUFACTURING SOLUTIONS
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From stick packs and packettes to multi-use, recloseable flexible packaging, engineered for performance, superior barrier protection, and standout shelf appeal.
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AST aseptic filling products address the unique processing requirements of biologics manufacturing to gently care for biologic products during the fill-finish process. Their highly accurate peristaltic dosing system uses single-use pharmaceutical grade tubing that has been optimized to keep shear stress to an absolute minimum. When exiting the fluid path through the filling needle, the motion control system maintains the fill needle within the container and slowly rises as the product is being dispensed to minimize splashing and foaming that could introduce stress to the product. Temperature controlled filling is also possible with the ASEPTiCell® and GENiSYS® systems. AST has experience dosing products at temperatures as low as 3°C.
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Used IWKA fully automatic continuous motion horizontal cartoner, model CPS-R Cartopack, capable of speeds up to 300 cpm, adjustable three chain machine on 6" centers for a carton size range: (length) 25 - 125MM longx 16 - 80MM wide x 55 - 180MM deep, Nordson 3100 Hot melt glue system, 3' long carton magazine with Siko guage adjustment, three head rotary carton feeder, 8' long adjustable bucket infeed system, presently set up to accomodate Guk sheet fed leaflet feeder for "U" type leaflet insertion, equipped with dual blister feed system and was last running blisters in an OTC pharmaceutical operation, 460 volt, serial# 279, built 1998.
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A technically superior, cGMP-compliant product, the AST Atmos Isolator features a groundbreaking user-friendly design, enhanced automation and efficiency, robust sterility assurance, and a disruptive VPHP solution providing industry-leading bio-decontamination cycle times.
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Used IMA Flexfill Series monoblock filler/plugger/capper, model F940 filler, serial# RE1003, stainless steel product contact surfaces, capable holding up to 8 fill heads (currently set up for 6 fill heads), 20 - 90 mm diameter x 40 - 180 mm height vial size range, includes model F572 plug/pump inserter, serial# 572031, vibrating hoppers and bowl feeders, mounted under Laminar flow fume hood, built 2003.