INSIGHTS ON LIQUID DOSE MANUFACTURING
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Ensure Sterility In Small-Batch Drug Production
Automation and sterility are critical for small-batch drug manufacturing. Learn how robotic isolators streamline vial filling, reduce contamination risk, and support advanced therapies with precision.
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CAR-T Cell Therapy For Cancer: The Patient's In The Process
Autologous cell therapies require absolute process repeatability. Learn how automated cryovial filling protects cell viability and eliminates manual variability.
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Rethinking Liquid Handling Automation
Labs today require more than precision—they need systems built for flexibility, reproducibility, and trust. Explore how automation is evolving to meet the real-world needs of modern scientific teams
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5 Ways Pre-Filled Syringes Contribute To Better Patient Outcomes
In our series on pre-filled syringes, we explore five key ways this delivery format is enhancing patient outcomes, not just through the medicine it contains, but through the device design itself.
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Shaping The Future Of ATMPs: Tailored Automation And Advanced Technologies For The Next Decade3/27/2025
From personalized treatments to large-scale viral vector production, the future of ATMPs hinges on optimized automation. We delve into the technologies driving this transformation and the challenges ahead.
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Streamline Global Regulatory Submissions5/21/2026
Discover a more streamlined approach with one accountable partner supporting regulatory submissions globally.
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EZ-fill® Kit: RTU Packaging Solutions For Fast Access To Small Volumes2/4/2025
Discover the EZfill Kit in action—an innovative solution designed to streamline and enhance precision in liquid handling, optimizing efficiency for pharmaceutical and bioprocess applications.
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The Successful Implementation Of A New Aseptic Filling Line10/10/2024
Discover how a Quality by Design approach can streamline the development of new sterile product filling lines, featuring a real-life example illustrating its effectiveness.
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Safe Syringe Solutions For Lipid Nanoparticles7/1/2026
Prefilled syringes improve lipid nanoparticle dosing accuracy and administration. Advanced containment solutions with cross-linked coatings preserve stability and accelerate development timelines.
LIQUID DOSE MANUFACTURING SOLUTIONS
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Shelf life stability is one of the key challenges for sensitive drug formulations, which have witnessed continuous growth in the past few years and are projected to grow even further in the future.
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Open RABS as a housing for aseptic processes, e.g., filling, loading, and unloading of freeze dryers. Product protection is achieved by a barrier (oRABS housing with gloves) between the operator and the product.
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Dec’s ability to provide end-to-end solutions from API manufacturing to primary packaging filling covers the complete range from R&D processes and small batches to large filling campaigns. Our solutions include state of the art robotics for the filling and handling of complex delivery systems like pre-filled syringes (PFS).
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2021 Vanrx (Cytiva) SA25 Aseptic Filling Workcell. The SA25 is a gloveless robotic isolator for aseptic fill/finish of nested vials, syringes, and cartridges. Fills 0.2–50 mL with format changeover in approximately 45 minutes. No glove ports; all filling and stoppering occurs robotically inside the isolator. GMP ready July 2022, GMP inactivation May 16, 2025. Last production 2023, four batches total. Serial# PSV00051. Built in British Columbia, Canada. Currently located in Songdo, Incheon, South Korea.
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AST aseptic filling products address the unique processing requirements of biologics manufacturing to gently care for biologic products during the fill-finish process. Their highly accurate peristaltic dosing system uses single-use pharmaceutical grade tubing that has been optimized to keep shear stress to an absolute minimum. When exiting the fluid path through the filling needle, the motion control system maintains the fill needle within the container and slowly rises as the product is being dispensed to minimize splashing and foaming that could introduce stress to the product. Temperature controlled filling is also possible with the ASEPTiCell® and GENiSYS® systems. AST has experience dosing products at temperatures as low as 3°C.