INSIGHTS ON LIQUID DOSE MANUFACTURING

  • Afton Scientific Capabilities Update January 2026: Fill/Finish
    1/27/2026

    Here, Michael Dunn outlines our current available capacity, including RABS operations, alongside the commissioning of a new Annex 1–compliant isolator filling line and expanded QC capabilities to ensure reliable, scalable execution.

  • Minimizing Particulate Risk
    5/13/2026

    While visible particles often draw immediate attention, visual inspection alone is insufficient, as subvisible particulate matter can pose equally significant risks to patient safety.

  • Barrel Filling Vs. Tip Filling A Syringe – Which Approach Should Be Used?
    1/3/2025

    There are two primary filling methods for pre-filled syringes. Explore the pros and cons of each approach, highlighting why barrel filling is generally preferred in the pharmaceutical industry.

  • BioTitan Retention Device Overview
    5/29/2025

    Learn about a retention device that provides robust fortification for single-use assemblies. Its 360-degree seal strengthens connections, reduces leak risks, and ensures process integrity for fluid transfer.

  • Benefits Of Isolator Technology In Fill-Finish
    12/10/2025

    Isolator technology enhances sterility assurance, reduces contamination risk, improves operator safety, and supports regulatory compliance, making it essential for modern aseptic fill-finish operations.

LIQUID DOSE MANUFACTURING SOLUTIONS

  • Leverage a pre-verified, integrated syringe platform. Accelerate timelines and reduce costs by eliminating drug-independent testing while streamlining regulatory submissions through one source.

  • AST’s ASEPTiCell® is a flexible fill/finish system that can efficiently process medium-sized clinical and commercial batches while meeting all cGMP requirements for cleanliness and sterility.

  • Used 300 sq ft BOC Edward freeze dryer, model LYOMAX 28, 316L stainless steel product contact surfaces with (13) 1170 mm wide x 1850 mm deep usable shelves, 115 mm shelf spacing, stoppering, external condenser with 300 kg ice capacity, refrigeration and vacuum skid with liquid natural gas refrigeration, model AV-LUS BOC Edward loading / unloading skid, 480 volt with controls, freeze dryer serial# MTE1930, built 2004.

  • AST’s ASEPTiCell® and GENiSYS® systems combine industry-proven technologies such as robotics and isolator-barrier systems to provide flexible pharmaceutical aseptic filling and closing of ready-to-use vials, syringes, and cartridges with a single machine. These innovative platforms use a modular design approach to provide a truly adaptive system with the capabilities and features necessary for cGMP production of clinical and commercial sterile injectable products.

  • A technically superior, cGMP-compliant product, the AST Atmos Isolator features a groundbreaking user-friendly design, enhanced automation and efficiency, robust sterility assurance, and a disruptive VPHP solution providing industry-leading bio-decontamination cycle times.