INSIGHTS ON LIQUID DOSE MANUFACTURING
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Accelerating SARS-CoV-2 Immunotherapy Speed To Clinic
A clinical-stage biotherapeutics company developing a COVID-19 immunotherapy searched for a solution to the difficulties it faced in scaling up its manufacturing operations due to limited resources.
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Barrel Filling Vs. Tip Filling A Syringe – Which Approach Should Be Used?
There are two primary filling methods for pre-filled syringes. Explore the pros and cons of each approach, highlighting why barrel filling is generally preferred in the pharmaceutical industry.
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Fill-Finish Contract Manufacturing: Trends, Challenges, And The Future
See why it's important to partner with a CDMO that’s investing in advanced sterile fill-finish capabilities to meet the demands of complex biologics, gene therapies, and mRNA-based products.
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De-Risking The Transition From Vial To Drug-Device Combination Product
When transitioning from a vial to a combination product system, the best approach is to have a holistic de-risk strategy with an intentional focus on the patient, the plan, and the product.
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Gain Speed To GMP Filling2/24/2025
Discover the advantages of a filling technology that provides faster readiness to good manufacturing practices (GMP) filling compared with traditional options.
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Explore A High-Performing Basal Medium And Feed Pairing5/8/2024
A customer sought to replace a chemically defined CHO medium with a more efficient medium and feed pairing strategy in bioreactors.
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CDMO Checklist To Choose The Right Aseptic Isolator1/9/2026
Selecting the right isolator for aseptic filling requires more than comparing features. Discover essential questions to ask and make informed decisions that align with your process and operational goals.
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Advancing Multiomics Through Intelligent Automation10/27/2025
Modern automation tackles hidden pipetting errors and boosts reproducibility. Discover how your lab can scale confidently, reduce rework, and accelerate multiomic workflows with built-in traceability.
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Robotics And Automation Addressing Production Shortages For Compounding Pharmacies9/11/2024
Drug shortages have increased the burden on compounding pharmacies. Robotics and automation can streamline processes, improve accuracy, and ensure quality to address challenges faced by these facilities.
LIQUID DOSE MANUFACTURING SOLUTIONS
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Pharmaceutical companies, researchers, scientists, and medical professionals work tirelessly to create and bring crucial vaccines and immunizations to the market. Understanding key product characterization details such as sterilization, secure packaging and optimal process conditions for manufacturing are necessary elements of the vaccine development process. The right vaccine development machines and filling equipment minimize obstacles to gaining this poduct and process knowledge. To aid the vaccine development process, AST’s vaccine filling machine, GENiSYS®C allows scientists and pharmaceutical companies to differentiate their vaccine product and develop data-driven manufacturing processes in more meaningful and scalable ways.
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The aseptic/sterile Fill-Finish equipment solutions need to be cGMP compliant, dependable and accurately designed to comply with the most recent revisions of the “Annex 1 Manufacture of Sterile Medicinal Products guidelines”. Newly designed equipment needs to accommodate for small batches, various speeds and containers, including RTU / RTF (Ready To Use or Ready To Fill) bottles, vials, cartridges, syringes and pre-sterile nested trays. Moreover, the filling equipment solution should also improve the ergonomic use for operators and maximize cleanroom efficiency.
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Medicines are highly sensitive to primary packaging components, which can affect compatibility with container closure systems. Discover Alba® syringes, designed for sensitive biologics, including highly concentrated drugs vulnerable to silicone interaction and ophthalmic medications.
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Flexible Containment Isolators provide containment standards better than can be achieved with Downflow Booth technology, and often compare favorably with a Rigid Isolator system.
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For highly accurate and controlled filling and weighing of sterile liquids, our proven and reliable technology prevents costly overfilling. The easy to validate aseptic filling machines are compatible with all high-tech production facility equipment, software and processes known in the pharmaceutical primary packaging industry.