Solid Dose Manufacturing

INSIGHTS ON SOLID DOSE MANUFACTURING

Improving Bioavailability Through Predictive Modeling Of Solubility Enhancement Strategies
In silico modeling cut through formulation guesswork for a compound with 0.015 mg/mL solubility, delivering an 8× Cmax and 5× AUC improvement and Phase I progression.
Predicting Drug-Loading Limits In Tablet Formulations
Learn how predictive percolation modeling identified critical drug-loading limits of ~20% for crystalline API and ~15% for SDD forms, cutting tablet formulation trial-and-error significantly.
High Potency APIs And The Evolving Demands Of Drug Development
See how higher API activity is changing expectations around containment, scalability, and cross‑functional alignment — and why early decisions now have a greater impact on long‑term success.
NanoImprove The Performance Of Your Formulations
Learn how Nanoforming can help improve the performance of your molecule by increasing drug loads, improving bioavailability, enhancing drug delivery profiles, and supporting product differentiation.

A Simple And Powerful Solution For Accelerating Dissolution
5/5/2026

Many poorly soluble drugs fail not because of low solubility, but because they dissolve too slowly. Learn how focusing on dissolution rate can unlock absorption gains using simple strategies.
Head Pressure In Your Hopper: What Is It, And How Do You Mitigate It?
7/30/2024

What is head pressure in your hopper and how does it relate to tablet press performance?
Taste-Masked Dosage Forms For Pediatric Oral Delivery: An Industrial Perspective
7/18/2024

Leveraging strategies and technologies for pediatric patient compliance for taste masking and controlled release in pharmaceutical products, enables flexibility in dosage and format options.
Optimizing Tablets For Even Splitting: The Pressure Sensitive Bisect Design
11/11/2024

The pressure-sensitive bisect design allows accurate tablet splitting by maximizing facet width, optimizing angles, and balancing radius values for durability and user-friendly administration.
The Importance Of Tablet Density Uniformity
10/7/2025

Non-uniform density causes many tablet failures. Learn how optimizing your formulation, tablet proportions, and tooling design ensures proper de-aeration for consistent quality.

Used Fuji Marumerizer Spheronizer, Model QJ700

Used Fuji Paudal Marumerizer spheronizer, model QJ700, stainless steel construction, with 2.0 mm grooved spheronizing plate with plate lift mechanism, jacketed bowl, side discharge with pneumatically operated plug valve, on base, serial 20050, built 1990.
Dust Free And Accurate Filling Of Flexible Intermediate Bulk Containers

Dec’s Big Bag filling stations offer a variety of packaging concepts. These range from simple inflatable gaskets to liner systems which, if necessary, can be integrated into a glove box. The filling systems are of a modular design depending on the process and containment requirements.
Pharmaceutical Solid Dose Manufacturing Equipment: Mixing, Blending, Dispensing, Containment

The pharmaceutical OSD manufacturing sector typically includes the final formulation to produce tablets and capsules, so the need to meet the current Good Manufacturing Practice (cGMP) regulations and quality standards is paramount.
When The Perfect Dosage Solution Is Somewhere Between A Liquid And Tablet

Powder in a bottle is used to accelerate formulation development and introduce new chemical entities into Phase I clinical trials.
Single-Use BioProcess Containers Brochure

Standard and customized 2D and 3D fluid containment systems. With a wealth of experience, knowledge, and solid quality processes behind every Thermo Scientific™ product, we will help you feel assured that your bioproduction process performs at its best.