INSIGHTS ON SOLID DOSE MANUFACTURING
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![ILC Dover]( "HPAPI Containment: A Full Lifecycle Safety Innovation")
HPAPI Containment: A Full Lifecycle Safety InnovationContaining highly potent APIs across a full operational lifecycle requires a structured approach that addresses hazard scoring, quality by design, performance testing, and safe enclosure disposal.
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![GettyImages-1627638093-glass-beaker-polyvinyl-alcohol]( "Solubility Enhancement Via Amorphous Solid Dispersions")
Solubility Enhancement Via Amorphous Solid DispersionsPolyvinyl alcohol (PVA) is a versatile polymer platform used to enhance solubility through hot melt extrusion. Explore the role it plays in drug solubility, hydrolysis, and thermal behaviors.
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![GettyImages-537472967 pharmaceutical, pills, medicine]( "How High Drug Load Nanocrystalline Tablets Lower Pill Burden")
How High Drug Load Nanocrystalline Tablets Lower Pill BurdenWe showcase the development of high drug load nanocrystal based tablets and prove that nanocrystals can match the pharmacokinetic performance of ASDs while reducing the overall pill burden.
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![Esco - DFB still]( "When To Consider Material And Personnel Airlocks For Downflow Booths")
When To Consider Material And Personnel Airlocks For Downflow BoothsStrategic use of airlocks in downflow booth design enhances pressure stability and containment. A risk-based approach ensures facility integration meets rigorous safety and compliance standards.
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HPAPIS Production: "Where Micrograms Matters"4/13/2026
In HPAPI manufacturing, micrograms make a difference. Risk‑based containment, smart facility design, and exposure limits safeguard people, product, and performance.
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The Critical Role Of Weight Uniformity In Tablet Manufacturing7/11/2024
For tablet manufacturers, tablet weight uniformity plays an essential role in ensuring pharmaceutical products deliver accurate amounts of key ingredients in a formulation.
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Barrel-Style vs. Standard Dust Cups vs. Bellows: The Essentials Behind Producing The Highest Quality Tablets Free From Contaminates7/30/2024
Dust cups and bellows are essential components in tablet manufacturing, utilized to prevent lubricants from contaminating the tablets.
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Minitablets: Enhancing Safety And Palatability For Pediatric Medicines1/15/2026
Leverage minitablet technology to create flexible, easy-to-swallow, and palatable pediatric formulations that improve adherence and meet evolving regulatory requirements.
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Bridging The Gap Between Product Readiness And Equipment Availability12/15/2025
Discover how manual precision at scale bridges packaging gaps, accelerates product launches, and ensures uninterrupted supply to deliver quality when automated equipment isn’t yet operational.
SOLID DOSE MANUFACTURING SOLUTIONS
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![high-potency-manufacturing-GettyImages-1731682643]( "High Potency API Development And Manufacturing")
Our HPAPI development and manufacturing spans preclinical through commercial supply across 13 global sites, with SafeBridge-certified containment and 30 years of cytotoxic compound expertise.
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![GettyImages-163720603 tablet press, OSD]( "Flexible Pharmaceutical Tablet Manufacturing Solutions")
With our pharmaceutical tablet manufacturing capabilities, we can take your product from formulation development through full-scale commercial production.
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![19 mm Baker Perkins Twin Screw Extruder]( "Used 19 mm Baker Perkins Twin Screw Extruder")
Used 19 MM APV Baker Perkins twin screw co rotating extruder, model MP-19-TC, 19 mm diameter screws, 40:1 l/d, electrically heated, water cooled barrel, split barrel design, 2 kw dc motor, 500 rpm screw spped, with Ktron main feeder, (2) Brabender auxiliary feeders, (3) Zenith melt pumps, FTS chiller, external control panel, with associated screws, screw elements, control panel, 220 volt, CE rated, APV serial# NEF990028-701/1, Baker Perkins serial# TS99535, project# 99TS196, built 1999.
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![iStock-870087778-powder]( "Powder Flow Properties & Characterization Services")
Basic Powder Flow Characterization [USP <1174>]:
A powder flow analysis is an indicator of how well formulation will release from the hopper during the tableting. It is important to know that the developed formulation is showing ‘Mass Flow’ or ‘Funnel Flow’ or ‘Rat Holing’.
Powder blend shows ‘Mass Flow’ when the entire solid bed is in motion during the discharge of material from the outlet. This is a ‘First-in-First-Out’ process. Hoppers offering ‘Mass Flow’ have steep and/or low-friction walls. This flow offers ‘No-Arching’, ‘Less Segregation’, and ‘Stable Powder Flow’.
When the hopper is not sufficiently steep and smooth enough to ensure sliding along its wall, the powder blend exhibit ‘Funnel Flow’. Such hoppers are sensitive to arching and ratholing. In this case, powder discharge from the hopper is not predictable.
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![Pharmaceutical Filling Systems.jpg]( "R&D Pharmaceutical Filling Systems: Powder And Liquid")
If you are looking for filling systems for different products such as liquids, powder or flow-resistant highly viscous materials, Dec provides a modular concept allowing to meet a variety of packaging that is appropriate in the field of research and development as well as clinical trials. Speed up your go-to-market strategy with innovation and modular thinking.
