INSIGHTS ON SOLID DOSE MANUFACTURING

• Ask Us Anything: Eric Fang On Lithiation Chemistry

  Eric Fang, General Manager of Snapdragon Chemistry, on why lithiation chemistry resists batch scale-up — and how a decade spent understanding static mixing lets Snapdragon carry these reactions from milligrams to metric tons.

• Spray Dry Biologics For Oral Dosage Forms

  Spray drying enables stable oral delivery of biologics by creating protective dry powders, improving bioavailability, stability, and targeted release compared with traditional formulation methods.

• Combining Powdose® And Diffucaps® For Precise Solid Oral Dosing

  Combining POWDOSE® and Diffucaps® enables precise, individualized solid oral dosing—improving drug delivery, patient compliance, and therapeutic outcomes in personalized medicine applications.

• Patient Adherence With A Novel Dosage Form

  A sprinkle formulation helps patients with tremors or dysphagia take medication more easily, improving adherence, comfort, and care through a novel, FDA-approved oral granule format.

• Predicting Softgel Stability And Shelf Life Using Accelerated Modeling

  7/15/2026

  Predict ibuprofen softgel shelf life in 21 days instead of years. ASAPprime modeling identified PEG-ester degradants as the limiting factor, estimating 5.5-year and 3.8-year shelf lives before long-term studies concluded.

• Overview Of Hot Melt Extrusion And Its Pharmaceutical Applications

  8/31/2026

  More than 40% of NCEs face aqueous solubility challenges. Here, we examine how hot melt extrusion addresses solubility, modified release, abuse deterrence, and scale-up across pharmaceutical development.

• From Disruption To Reinvention: The Story Of API-In-Capsule Technology And Its Future

  8/19/2025

  Discover how advanced API-in-capsule technology addresses previous limitations, providing a flexible and efficient path for drug candidates from development to clinical trials.

• Modeling Polymer Interactions To Improve Amorphous Solid Dispersion Stability

  7/15/2026

  Molecular dynamics modeling revealed how hydrogen bonding between PVP and Eudragit drives stable amorphous solid dispersion formation, cutting formulation screening time significantly.

• An Alternative Method Of Drug-Excipient Characterization

  12/30/2024

  Isothermal microcalorimetry (IMC) rapidly screens API-excipient compatibility, detecting physical and chemical interactions faster than conventional methods, saving time and effort in pharmaceutical formulation development.