Read how upgrading to modern single-use powder handling gets a product to market without time wasted on complicated weigh and dispense steps, cleaning validations or powder in the air and in the suite.
Avoid inconsistent and even dangerous dosages being tableted by monitoring segregation during the process.
Large molecule biopharmaceuticals can be prone to oxidation and to prevent this from occurring, the headspace is often purged with an inert gas during filling to ensure a longer shelf life.
Single-use transfer technology has been used in biopharma manufacturing for years. However, upstream powder-handling processes haven’t been improved upon. Now, the industry is seeing a need for better ways to bring powders to the hydration process and begin upstream biologic manufacturing.
Managing the risks associated with potent compounds requires a knowledgeable team as well as the design and implementation of an effective safety program.
This paper describes how to understand punch length, how to measure it correctly, and how wear affects length and tablet consistency. It also addresses the importance of specifying cup-depth tolerances.
Finding the right mixing equipment isn’t as simple as selecting an item from a menu. This article is a guide to considerations when choosing pharmaceutical mixing equipment and vendors for a facility.
With properly cleaned and maintained tooling, tablet manufacturers can expect the highest quality of tablets and a longer production life from their tooling.
Identifying the source of product flow problems and correcting them with the right piece of equipment will result in more efficient and quality manufacturing.
Used 1.5" Schenck volumetric feeder, model MODMC-IG-2A, stainless steel product contact surfaces, with approximately 1.5" diameter x 17" long discharge screw, driven by 1 hp motor, .5 hp hopper agitator, serial# 105850-06C-MECGM.
The MicroSphere is a clean, cost-effective C.A.I for sterile compounding, that is USP <797> compliant.
With the explosion in usage of High Potency Active Pharmaceutical Ingredients (HPAPI’s), containment of these compounds and personnel protection have become of major concern to scientists. In order to combat potentially high capital outlays for equipment, many companies are looking at alternative methods of containment, including modification of existing equipment. The Hybrid Isolator, offered by Flow Sciences, Inc., is one such method of reducing the cost of containment.
Unused O'Hara LabCoat M5 coating pan, model LCM M5, stainless steel construction with 15" and 12" perforated pans with plenums, spray gun with on board peristaltic pump, Siemens PLC controls with Simatic HMI, .33 hp pan drive, 1/60/240 volt, serial# 4453, built February 2019 and Unused.
A manual or automatic sampling valve can be adapted at the hopper or container powder outlet with a standard containment or bottle system.