INSIGHTS ON SOLID DOSE MANUFACTURING
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![Solubility And Improved Patient Outcomes-GettyImages-2277363545]( "Solubility And Improved Patient Outcomes")
Solubility And Improved Patient OutcomesPoor solubility poses major development challenges. Innovative formulation technologies and careful excipient selection can improve bioavailability and product performance.
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![osd-manufacturing-GettyImages-2145984822]( "De-Risking Production Of Complex Oral Solid Dosages: Considerations & Key Capabilities")
De-Risking Production Of Complex Oral Solid Dosages: Considerations & Key CapabilitiesReduce formulation and scale-up risk with integrated development and manufacturing expertise for complex OSD products.
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![Eric Fang 2]( "Ask Us Anything: Eric Fang On Lithiation Chemistry")
Ask Us Anything: Eric Fang On Lithiation ChemistryEric Fang, General Manager of Snapdragon Chemistry, on why lithiation chemistry resists batch scale-up — and how a decade spent understanding static mixing lets Snapdragon carry these reactions from milligrams to metric tons.
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![GettyImages-950086574-microscope-scientist-pill-development]( "Minitablets: Enhancing Safety And Palatability For Pediatric Medicines")
Minitablets: Enhancing Safety And Palatability For Pediatric MedicinesLeverage minitablet technology to create flexible, easy-to-swallow, and palatable pediatric formulations that improve adherence and meet evolving regulatory requirements.
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Adapting To Evolving Needs: How Modular Cleanrooms Enhance Safety In Pharmaceutical Manufacturing6/9/2026
High-potency therapies demand stringent containment and worker safety. Discover how scalable, modular infrastructure simplifies compliance and protects product integrity in regulated facilities.
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Rheological Properties Of Pharmaceutical Excipients: Lactose Monohydrate And Carboxymethyl Cellulose12/30/2024
Explore lactose monohydrate and CMC rheology, highlighting their flow, cohesion, and compressibility properties to optimize pharmaceutical formulations under varying stress and temperature conditions.
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Reducing Uncertainty In Early Oral Drug Development8/31/2026
Five recurring decision points in early oral solid dose development carry outsized downstream consequences. AI/ML-driven predictive modeling is reframing how teams manage those decisions under API and timeline constraints.
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Improving Stability Through Science-Led OSD Reformulation10/13/2026
A marketed multivitamin tablet spanning a 0.03% to 46% w/w range failed early in accelerated stability testing. Mechanism-led reformulation and a switch to direct compression changed the outcome.
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Ask Us Anything: Hannah McLachlan on Crystallization In Peptide Development7/24/2026
Hannah McLachlan, Project Scientist IV at Cambrex Edinburgh, on what crystallization screening delivers for peptide therapeutics — more stable material, higher purity, and a molecule clients can store without specialist infrastructure.
SOLID DOSE MANUFACTURING SOLUTIONS
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![osd-small-molecule-GettyImages-157287767]( "Controlled Release Drug Delivery And Manufacture")
From child-resistant designs to user-friendly formats, pediatric packaging solutions help improve safety, dosing accuracy and efficient product delivery.
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![Tablet Press NP255]( "Robust Mid-Sized Tablet Press")
Explore a mid-sized tablet press designed with optional features including force monitoring, a power rotary forced feeder, a tablet reject chute, and a hopper vibration unit.
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![ThermoScientific]( "Single-Use BioProcess Containers Brochure")
Standard and customized 2D and 3D fluid containment systems. With a wealth of experience, knowledge, and solid quality processes behind every Thermo Scientific™ product, we will help you feel assured that your bioproduction process performs at its best.
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![iStock-870087778-powder]( "Powder Flow Properties & Characterization Services")
Basic Powder Flow Characterization [USP <1174>]:
A powder flow analysis is an indicator of how well formulation will release from the hopper during the tableting. It is important to know that the developed formulation is showing ‘Mass Flow’ or ‘Funnel Flow’ or ‘Rat Holing’.
Powder blend shows ‘Mass Flow’ when the entire solid bed is in motion during the discharge of material from the outlet. This is a ‘First-in-First-Out’ process. Hoppers offering ‘Mass Flow’ have steep and/or low-friction walls. This flow offers ‘No-Arching’, ‘Less Segregation’, and ‘Stable Powder Flow’.
When the hopper is not sufficiently steep and smooth enough to ensure sliding along its wall, the powder blend exhibit ‘Funnel Flow’. Such hoppers are sensitive to arching and ratholing. In this case, powder discharge from the hopper is not predictable.
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![Manesty Unipress Tablet Press.jpg]( "Used Manesty 34 Station Unipress Tablet")
Used Manesty Unipress rotary table press, 34 station, keyed upper punch guides, 6.5 ton main compression, 1 ton pre compression, B tooled, 11 mm max tablet diameter, 18 mm max depth of fill, single side with force feeder with feed hopper, with control cabinet, up to 247,200 tablets/hour, serial# 15458 84.
