Solid Dose Manufacturing

INSIGHTS ON SOLID DOSE MANUFACTURING

The Crucial Role Of Cleaning In Effective VPHP Decontamination For Isolators
Effective isolator cleaning is crucial for vapor phase hydrogen peroxide (VPHP) decontamination. Proper tools, techniques, and training ensure sterility, and regulatory compliance.
Predicting Softgel Stability And Shelf Life Using Accelerated Modeling
Predict ibuprofen softgel shelf life in 21 days instead of years. ASAPprime modeling identified PEG-ester degradants as the limiting factor, estimating 5.5-year and 3.8-year shelf lives before long-term studies concluded.
Understanding Aseptic Powder Filling: Key Principles And Techniques
Pharmaceutical production of sterile powders presents unique hurdles. Explore the core principles and advanced techniques vital for aseptic filling, from containment to precise dosage control.
When To Consider Material And Personnel Airlocks For Downflow Booths
Strategic use of airlocks in downflow booth design enhances pressure stability and containment. A risk-based approach ensures facility integration meets rigorous safety and compliance standards.

Solubility Enhancement Via Amorphous Solid Dispersions
2/27/2025

Polyvinyl alcohol (PVA) is a versatile polymer platform used to enhance solubility through hot melt extrusion. Explore the role it plays in drug solubility, hydrolysis, and thermal behaviors.
Benefits Of Single-Use Isolators For Cytotoxic Payload Handling
6/15/2026

Managing cytotoxic ADC payloads in shared containment facilities creates mounting compliance, safety, and operational costs that single-use isolator technology is designed to address.
Combining Patient Centricity And Commercial Viability In Pediatric Product Development
8/15/2024

Medication acceptance and adherence are critical concerns in pediatric populations due to these patients’ rapid anatomical and physiological development.
A Powerful Non-Destructive Tool For Tablet Characterization
10/6/2025

Discover how X-ray micro-CT provides vital, non-destructive analysis of a tablet’s internal 3D physical structure. This structural insight is essential for troubleshooting defects and confirming performance.
Optimizing Yield, Purity, And Scalability In A Cost-Effective Manner During Process Development
7/23/2026

Daniele Vigo, Assistant Director at Cambrex Milan, on getting yield, purity, and scalability right without burning through the budget.

Used Filamatic Pharmaceutical Aseptic Filling System

Used Filamatic Filler, Model AB-5, with fill piston and filling nozzle, 110 volt, serial# 022578.
Used Elizabeth Hata Pharmaceutical 10 Station Tablet Press

Used Elizabeth Hata R&D tablet press, model EP200, B/D tooled with 10 station turret, 5 stations each B and D, 16 mm B, 22 mm D max tablet diameter, 17 mm B, 18 mm D max depth of fill, rated up to 6000 tablets/hour, with feed hoppers and feed frames, Machine #81, built 2011.
PTS Powder Transfer System®: Dense Phase Powder Conveying

PTS Powder Transfer System® challenges convention by using both vacuum and pressure to move powders as if they were liquids. This eliminates the need for gravity charging and therefore making multi floor processes a requirement of the past.
Used Powrex 25 Liter High Shear Mixer

Used Powrex high shear mixer, model FM-VG-25, stainless steel construction, 15 liter working capacity with high speed chopper driven by 1.5 kw motor, main shaft driven by 3.7 kw motor, with controls, serial# 903222, built 1990.
Flexible Containment Isolators

Flexible Containment Isolators provide containment standards better than can be achieved with Downflow Booth technology, and often compare favorably with a Rigid Isolator system.