INSIGHTS ON SOLID DOSE MANUFACTURING
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![GettyImages-1499814881-pills-production-line]( "Converting From A Spray-Dried Dispersion To A KinetiSol Formulation In <5 Months")
Converting From A Spray-Dried Dispersion To A KinetiSol Formulation In <5 MonthsA development team quickly turned a low‑bioavailability, high‑burden formulation into a streamlined, clinically improved version, boosting exposure, simplifying manufacturing, and accelerating progress.
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![GettyImages-1669461851 tablet manufacturing]( "Optimizing Tablets For Even Splitting: The Pressure Sensitive Bisect Design")
Optimizing Tablets For Even Splitting: The Pressure Sensitive Bisect DesignThe pressure-sensitive bisect design allows accurate tablet splitting by maximizing facet width, optimizing angles, and balancing radius values for durability and user-friendly administration.
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![GettyImages-950086574-oral-solid-OSD-pill-tablet-capsule-development]( "5 Hidden Risks In Early-Phase OSD Formulation Development")
5 Hidden Risks In Early-Phase OSD Formulation DevelopmentEarly formulation decisions in OSD development carry risks that may not surface until later stages, when the cost of course correction is significantly higher.
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![ILC_SUS_ Isolator]( "Benefits Of Single-Use Isolators For Cytotoxic Payload Handling")
Benefits Of Single-Use Isolators For Cytotoxic Payload HandlingManaging cytotoxic ADC payloads in shared containment facilities creates mounting compliance, safety, and operational costs that single-use isolator technology is designed to address.
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Achieving Licensing For A Healthcare Solution6/16/2025
Facing strict regulations and tricky powders, a healthcare client sought an advanced filling solution. Learn how an expert collaboration led to licensed product, boosting precision and productivity.
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Understanding Aseptic Powder Filling: Key Principles And Techniques3/27/2025
Pharmaceutical production of sterile powders presents unique hurdles. Explore the core principles and advanced techniques vital for aseptic filling, from containment to precise dosage control.
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Lipid Formulation Development: Why Softgels Are The Technology Of Choice8/31/2026
Low bioavailability affects roughly 80% of APIs, yet many drug developers default to standard OSD forms. This paper examines why softgels deserve earlier consideration in formulation strategy.
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Improving API Solubility Using Hot Melt Extrusion Formulation2/27/2025
Solubility of active pharmaceutical ingredients (APIs) is a challenge in drug development. Discover how hot melt extrusion with polyvinyl alcohol enhances API solubility and stability to offer improved drug delivery.
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Combining Powdose® And Diffucaps® For Precise Solid Oral Dosing6/30/2025
Combining POWDOSE® and Diffucaps® enables precise, individualized solid oral dosing—improving drug delivery, patient compliance, and therapeutic outcomes in personalized medicine applications.
SOLID DOSE MANUFACTURING SOLUTIONS
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![3P - robofil]( "roboFIL™: Fully Automated Robotic System For Aseptic Filling Of RTU Containers")
Enhance your aseptic processing with adaptable robotic technology. Handle vials, syringes, and cartridges seamlessly on one platform, ensuring quick changeovers and high quality.
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![osd]( "Pharmaceutical Solid Dose Manufacturing Equipment: Mixing, Blending, Dispensing, Containment")
The pharmaceutical OSD manufacturing sector typically includes the final formulation to produce tablets and capsules, so the need to meet the current Good Manufacturing Practice (cGMP) regulations and quality standards is paramount.
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![Natoli scientists]( "Pharmaceutical Preformulation Support Services")
Partner with Natoli Scientific during the earliest stages. Our scientific expertise with state-of-the-art analytical capabilities is ready to take any preformulation challenge.
Natoli scientific has an expertise of handling a wide range of APIs for the development of oral solids. We apply principles of ‘Quality by Design’ to define Critical Material Attributes (CMA), Critical Process Parameters (CPP), Critical Quality Attributes (CQA) and Quality Target Product Profiles (QTPP). Because we believe that understanding material and process as much as possible in the early life cycle of drug product development program is an insurance for further development path. Keeping your practices up to date with the ICHQ8 regulatory guidance issued by the US FDA. This is also a gate way for a smooth ride of product in the different stages of product development stages.
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![Pharmaceutical industry research, development data-GettyImages-1354838510]( "Dedicated To Development: Bend, Oregon's Impact")
A facility overview highlighting solubility enhancement and advanced drug delivery capabilities, including a predictive formulation platform and project timeline benchmarks.
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![ThermoScientific]( "Single-Use BioProcess Containers Brochure")
Standard and customized 2D and 3D fluid containment systems. With a wealth of experience, knowledge, and solid quality processes behind every Thermo Scientific™ product, we will help you feel assured that your bioproduction process performs at its best.
