INSIGHTS ON SOLID DOSE MANUFACTURING
-
![GettyImages-498013412-laboratory-flask-water-solubility-dropper]( "Improving Bioavailability Through Predictive Modeling Of Solubility Enhancement Strategies")
Improving Bioavailability Through Predictive Modeling Of Solubility Enhancement StrategiesIn silico modeling cut through formulation guesswork for a compound with 0.015 mg/mL solubility, delivering an 8× Cmax and 5× AUC improvement and Phase I progression.
-
![Scaling Spray-Dried Dispersions for Commercial Success Enabling Medicines Through Scale, Capacity, and Supply Resilience]( "Scaling Spray-dried Dispersions For Commercial Success: Scale, Capacity, Supply")
Scaling Spray-dried Dispersions For Commercial Success: Scale, Capacity, SupplyScaling SDDs takes more than larger batches. Explore how early planning and process understanding can preserve performance and reduce commercialization risk.
-
![cdmo-solid-dose-GettyImages-1432665138]( "Safely Scaling High Potency API Manufacturing")
Safely Scaling High Potency API ManufacturingScaling HPAPI production demands disciplined containment and exposure control. Integrated operating models help manage risk while enabling compliant, reliable scale‑up.
-
![Natoli - tool and tablet]( "Tablet Consistency And Punch Length – A Pragmatic Perspective For European Manufacturers")
Tablet Consistency And Punch Length – A Pragmatic Perspective For European ManufacturersTablet consistency relies on a balance of formulation, press mechanics, and tooling. Learn why punch length tolerance is often overstated and what other critical factors truly drive quality and uniformity.
-
Rheological Properties Of Pharmaceutical Excipients: Lactose Monohydrate And Carboxymethyl Cellulose12/30/2024
Explore lactose monohydrate and CMC rheology, highlighting their flow, cohesion, and compressibility properties to optimize pharmaceutical formulations under varying stress and temperature conditions.
-
Innovations, Solutions, And USP <1062> With Scale Up11/4/2025
Optimize tablet compression by simplifying calibration, speeding up changeovers, and utilizing advanced laser inspection to prevent critical punch tip wear and maintain quality.
-
Accelerating An Innovative High Potency Oncology Therapy To Market5/13/2026
Assimilate how disciplined containment, proactive risk management, and collaboration accelerate oncology programs under tight timelines while protecting quality, safety, and global launch readiness.
-
5 Questions To Ask Before Selecting A High-Containment Isolator10/29/2026
Containment performance alone does not settle isolator selection. Workflow fit, operator ergonomics, transfer and cleaning, and long-term operation each shape whether a system works in practice.
-
Delivering API-In-Capsule For Potent, Low-Flow Compounds9/9/2026
See how an automated capsule-filling approach addressed poor-flow APIs, improved operator safety, and supported fast scale-up for clinical supply needs.
SOLID DOSE MANUFACTURING SOLUTIONS
-
![Used Key International Tablet Press]( "Used Key International Tablet Press")
Used Key International single station bench top tablet press, model: SC-2. 1.5 ton compression pressure, approximately .5" max tablet diameter, .5625" max depth of fill, manual operation, serial# JI4786.
-
![Doctor holding antibiotic pills-GettyImages-2271436785]( "OSD Express IND")
A structured overview of a Phase I oral solid dose development solution promising GMP clinical batch delivery in 25 weeks from API receipt, with defined scope and flexible options.
-
![cdmo-solid-dose-GettyImages-1432665138]( "Solid Form Screening")
Solid form screening optimizes drug properties by evaluating polymorphs, salts, and cocrystals to improve solubility, stability, and manufacturability using advanced analytics.
-
![Natoli scientists]( "Pharmaceutical Preformulation Support Services")
Partner with Natoli Scientific during the earliest stages. Our scientific expertise with state-of-the-art analytical capabilities is ready to take any preformulation challenge.
Natoli scientific has an expertise of handling a wide range of APIs for the development of oral solids. We apply principles of ‘Quality by Design’ to define Critical Material Attributes (CMA), Critical Process Parameters (CPP), Critical Quality Attributes (CQA) and Quality Target Product Profiles (QTPP). Because we believe that understanding material and process as much as possible in the early life cycle of drug product development program is an insurance for further development path. Keeping your practices up to date with the ICHQ8 regulatory guidance issued by the US FDA. This is also a gate way for a smooth ride of product in the different stages of product development stages.
-
![GlobePharma Single Station Tablet Press]( "Used GlobePharma Single Station Pharmaceutical Tablet Press")
Used GlobePharma Single Station Tablet Press.
