INSIGHTS ON SOLID DOSE MANUFACTURING
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Engineering Challenges Of Designing Pharmaceutical Isolators
Designing pharmaceutical isolators requires navigating complex engineering hurdles, from ensuring chemical compatibility to optimizing airflow and pressure. Explore the critical considerations that guarantee drug manufacturing safety and efficiency.
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The Future Of Sustainable Amorphous Dispersion Development
Sustainable amorphous dispersion cuts cost, risk, and timelines by removing solvent waste, simplifying manufacturing, strengthening supply chains, and scaling efficiently to commercialization.
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Low-Bioburden Powders For Terminal Sterilisation
Low‑bioburden powders for reconstitution demand strict microbial control, advanced formulation, and specialised manufacturing, making CDMO expertise vital for modern biopharma.
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Pharmaceutical X-Ray Counts Capsules And Pills
See how advanced x-ray inspection technology verifies correct pill count, identifies broken capsules, and detects foreign contaminants in pharmaceutical sachet packets.
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Decontamination Of Aseptic Pharmaceutical Isolators Using Vaporized And Aerosolized Hydrogen Peroxide8/26/2026
Aerosolized hydrogen peroxide decontamination cuts isolator cycle times from 70 to 15 minutes while drastically reducing biocide and overall energy usage.
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M6 Tablet Metal Detector For Pharmaceutical And Nutraceutical Production8/15/2025
Ensure the safety and quality of your tablets and capsules with a metal detector designed for stability and high sensitivity in pharmaceutical and nutraceutical production.
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Patient Adherence With A Novel Dosage Form11/13/2025
A sprinkle formulation helps patients with tremors or dysphagia take medication more easily, improving adherence, comfort, and care through a novel, FDA-approved oral granule format.
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Direct API Capsule Filling: A Faster Path To Market9/16/2026
Direct API capsule filling eliminates complex formulation steps, leveraging volumetric drum dosing and 100% net weight verification to accelerate drug development timeline efficiency.
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Ask Us Anything: Daniele Vigo On Cost-Effective Process Development7/23/2026
Daniele Vigo, Assistant Director at Cambrex Milan, on getting yield, purity, and scalability right without burning through the budget.
SOLID DOSE MANUFACTURING SOLUTIONS
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Our rotary turret uses proven tablet-press -based, principles. It progressively compresses powder into small pockets on a continuously rotating disk using a combination of rotors and pins. The resultant doses are then transferred to blister strip as it passes underneath the disk.
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Used ACG capsule filler, model AF TLab, speeds from 6000-25000 capsules/hour, 220 volt, CE design, batch# 2522/10/01, serial# 102, built 2020. includes ACG capsule polisher unit, model DP100, batch# DP62/30/21, serial# 2664, built 2020 and ACG empty capsule sorter, model ECS 100, batch# EC60/30/03, serial# 2098, built 2020.
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Basic Powder Flow Characterization [USP <1174>]:
A powder flow analysis is an indicator of how well formulation will release from the hopper during the tableting. It is important to know that the developed formulation is showing ‘Mass Flow’ or ‘Funnel Flow’ or ‘Rat Holing’.
Powder blend shows ‘Mass Flow’ when the entire solid bed is in motion during the discharge of material from the outlet. This is a ‘First-in-First-Out’ process. Hoppers offering ‘Mass Flow’ have steep and/or low-friction walls. This flow offers ‘No-Arching’, ‘Less Segregation’, and ‘Stable Powder Flow’.
When the hopper is not sufficiently steep and smooth enough to ensure sliding along its wall, the powder blend exhibit ‘Funnel Flow’. Such hoppers are sensitive to arching and ratholing. In this case, powder discharge from the hopper is not predictable.
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An oral solid pilot plant paired with pharmaceutical technology and analytical development labs, built inside a commercial production campus, supports work through clinical batches and small-scale commercial supply.
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Personal protection pharmaceutical isolators enables personal protection for operators when handling toxic substances.