INSIGHTS ON SOLID DOSE MANUFACTURING
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![cdmo-solid-dose-GettyImages-1432665138]( "Safely Scaling High Potency API Manufacturing")
Safely Scaling High Potency API ManufacturingScaling HPAPI production demands disciplined containment and exposure control. Integrated operating models help manage risk while enabling compliant, reliable scale‑up.
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![GettyImages-1381220899 tablets, pills, OSD, small molecule]( "Powder Rheology: Gateway For Tablet Sticking Insights")
Powder Rheology: Gateway For Tablet Sticking InsightsPowder rheology offers a scientific method to predict and mitigate tablet sticking issues, helping to ensure smoother pharmaceutical production cycles through early material and tooling selection.
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![Douglas CDMO - Smart Softgels]( "Smart Softgels: Driving Innovation In Pharma")
Smart Softgels: Driving Innovation In PharmaLearn about how softgels are poised to facilitate innovation in the pharmaceutical industry as well as ongoing advancements in optimizing drug bioavailability through nano formulations.
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![GettyImages-1140632275-tablet-bottle-manufacturing]( "The Importance Of Tablet Density Uniformity")
The Importance Of Tablet Density UniformityNon-uniform density causes many tablet failures. Learn how optimizing your formulation, tablet proportions, and tooling design ensures proper de-aeration for consistent quality.
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De-Risking Production Of Complex Oral Solid Dosages: Considerations & Key Capabilities7/13/2026
Reduce formulation and scale-up risk with integrated development and manufacturing expertise for complex OSD products.
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Advancements In GLP-1 Analog Formulation: Overcoming Challenges2/3/2025
Oral GLP-1 formulations represent a groundbreaking advance in obesity treatment to offer improved patient comfort and adherence while expanding the therapeutic market.
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Low-Bioburden Powders For Terminal Sterilisation2/24/2026
Low‑bioburden powders for reconstitution demand strict microbial control, advanced formulation, and specialised manufacturing, making CDMO expertise vital for modern biopharma.
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Optimising Solubility: Selecting The Right Technology For Early Drug Development5/6/2026
Discover how selecting the right solubility‑enhancing technology improves early exposure, supports flexible dosing, and lays a strong foundation for downstream oral drug development.
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Pharmaceutical X-Ray Counts Capsules And Pills8/15/2025
See how advanced x-ray inspection technology verifies correct pill count, identifies broken capsules, and detects foreign contaminants in pharmaceutical sachet packets.
SOLID DOSE MANUFACTURING SOLUTIONS
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![Isolators.jpg]( "Dispensing And Sampling Pharmaceutical Isolators")
Dec provide custom designed isolators for dispensing and/or sampling from various containers such as bags and drums into intermediate packagings or for direct charging into process equipment. These systems offer high containment and a controlled environment offering fast cleaning and drying features allowing for swift product changes.
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![iStock-870087778-powder]( "Powder Flow Properties & Characterization Services")
Basic Powder Flow Characterization [USP <1174>]:
A powder flow analysis is an indicator of how well formulation will release from the hopper during the tableting. It is important to know that the developed formulation is showing ‘Mass Flow’ or ‘Funnel Flow’ or ‘Rat Holing’.
Powder blend shows ‘Mass Flow’ when the entire solid bed is in motion during the discharge of material from the outlet. This is a ‘First-in-First-Out’ process. Hoppers offering ‘Mass Flow’ have steep and/or low-friction walls. This flow offers ‘No-Arching’, ‘Less Segregation’, and ‘Stable Powder Flow’.
When the hopper is not sufficiently steep and smooth enough to ensure sliding along its wall, the powder blend exhibit ‘Funnel Flow’. Such hoppers are sensitive to arching and ratholing. In this case, powder discharge from the hopper is not predictable.
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![Natoli - CT Scan_450x300]( "Precision CT Scan Services: Uncovering Flaws For Flawless Tablets")
At Natoli, we know that quality is paramount. Our cutting‐edge Precision CT Scan Service is designed to detect even the subtlest imperfections in tablets, ensuring you achieve the highest standards of quality every time.
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![high-potency-manufacturing-GettyImages-1731682643]( "High Potency API Development And Manufacturing")
Our HPAPI development and manufacturing spans preclinical through commercial supply across 13 global sites, with SafeBridge-certified containment and 30 years of cytotoxic compound expertise.
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![Fitzpatrick Chilsonator]( "Used Fitzpatrick Roller Compactor: Chilsonator: 1.5LX8D")
Used Fitzpatrick Chilsonator roller compactor, model 1.5LX8D, with 8" diameter x 1.5" wide grooved rolls, vertical and horizontal pre-compression screws, serial# 489.
