INSIGHTS ON SOLID DOSE MANUFACTURING
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Converting From A Spray-Dried Dispersion To A KinetiSol Formulation In <5 Months
A development team quickly turned a low‑bioavailability, high‑burden formulation into a streamlined, clinically improved version, boosting exposure, simplifying manufacturing, and accelerating progress.
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Enabling Complex Phase IIa Dosing Through Flexible Clinical Packaging Design
Discover how flexible, patient‑centric clinical packaging supports complex Phase IIa dosing while protecting timelines, ensuring compliance, and avoiding costly primary packaging changes.
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Combining Powdose® And Diffucaps® For Precise Solid Oral Dosing
Combining POWDOSE® and Diffucaps® enables precise, individualized solid oral dosing—improving drug delivery, patient compliance, and therapeutic outcomes in personalized medicine applications.
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Solubility Enhancement Via Amorphous Solid Dispersions
Polyvinyl alcohol (PVA) is a versatile polymer platform used to enhance solubility through hot melt extrusion. Explore the role it plays in drug solubility, hydrolysis, and thermal behaviors.
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Benefits Of Single-Use Isolators For Cytotoxic Payload Handling6/15/2026
Managing cytotoxic ADC payloads in shared containment facilities creates mounting compliance, safety, and operational costs that single-use isolator technology is designed to address.
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Minitablets: Enhancing Safety And Palatability For Pediatric Medicines1/15/2026
Leverage minitablet technology to create flexible, easy-to-swallow, and palatable pediatric formulations that improve adherence and meet evolving regulatory requirements.
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Achieving Manufacturing Efficiency In OSD Manufacturing10/16/2024
Gain expert insight into the importance of instrumented tablet presses in assessing formulation properties, the role of tablet cup configurations, and scalability parameters for successful product transfer.
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Modeling Polymer Interactions To Improve Amorphous Solid Dispersion Stability7/15/2026
Molecular dynamics modeling revealed how hydrogen bonding between PVP and Eudragit drives stable amorphous solid dispersion formation, cutting formulation screening time significantly.
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Improving Bioavailability Through Predictive Modeling Of Solubility Enhancement Strategies7/15/2026
In silico modeling cut through formulation guesswork for a compound with 0.015 mg/mL solubility, delivering an 8× Cmax and 5× AUC improvement and Phase I progression.
SOLID DOSE MANUFACTURING SOLUTIONS
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Natoli Engineering now offers AIM™ Data Acquisition & Analytical Software for the Natoli NP-RD10A research and development tablet press. The combination of AIM™ Software and this R&D tablet press enables the researcher to evaluate formulation properties and identify potential tableting issues—including capping, lamination, sticking/picking, and tablet robustness—during the tablet development process. Plus, the software can optimize tablet tensile strength and lubrication for successful large-scale manufacturing production.
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The patented Transbatch system relies on modern technology to safely convey and dose granules and other solids under critical installation conditions in terms of both transfer length and height.
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Esco Pharma's Downflow Booth Generation 3 (DFBG3) is a new generation of Esco powder containment booth which provides simplicity with assured quality.
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Learn how closed systems, advanced facilities, and flexible batch strategies support safe development and reliable commercial supply.
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The pneumatic POSITIVE pressure conveying (or PRESSURE conveying) is dedicated to the transfer of larger quantities of powder or granulates under following conditions: