INSIGHTS ON SOLID DOSE MANUFACTURING

• Lipid Formulation Development: Why Softgels Are The Technology Of Choice

  Low bioavailability affects roughly 80% of APIs, yet many drug developers default to standard OSD forms. This paper examines why softgels deserve earlier consideration in formulation strategy.

• Modeling Polymer Interactions To Improve Amorphous Solid Dispersion Stability

  Molecular dynamics modeling revealed how hydrogen bonding between PVP and Eudragit drives stable amorphous solid dispersion formation, cutting formulation screening time significantly.

• A Brief History Of Aseptic Processing

  From Bunsen burners to advanced isolators, aseptic processing has evolved significantly. Delve into the evolution of this crucial manufacturing method, from its early sterilization techniques to today's highly controlled and regulated environments.

• FastLok™ Die Table Surface Overview

  Learn about a toolless, removable surface that allows for rapid, on-turret plate replacement in minutes, not weeks, significantly improving operational efficiency.

• Tablet Consistency And Punch Length – A Pragmatic Perspective For European Manufacturers

  10/7/2025

  Tablet consistency relies on a balance of formulation, press mechanics, and tooling. Learn why punch length tolerance is often overstated and what other critical factors truly drive quality and uniformity.

• Predicting Food Effects In Oral Drug Delivery Using PBPK Modeling

  7/15/2026

  Learn how integrated PBPK and molecular dynamics modeling predicted an ~11% fed-state Cmax increase for fenofibrate, giving formulation teams earlier, mechanistic insight into food-dependent absorption.

• The Future Of Sustainable Amorphous Dispersion Development

  4/15/2026

  Sustainable amorphous dispersion cuts cost, risk, and timelines by removing solvent waste, simplifying manufacturing, strengthening supply chains, and scaling efficiently to commercialization.

• Solubility Enhancement Via Amorphous Solid Dispersions

  2/27/2025

  Polyvinyl alcohol (PVA) is a versatile polymer platform used to enhance solubility through hot melt extrusion. Explore the role it plays in drug solubility, hydrolysis, and thermal behaviors.

• How High Drug Load Nanocrystalline Tablets Lower Pill Burden

  3/12/2025

  We showcase the development of high drug load nanocrystal based tablets and prove that nanocrystals can match the pharmacokinetic performance of ASDs while reducing the overall pill burden.