INSIGHTS ON SOLID DOSE MANUFACTURING

• Isolators For Pharmacy Compounding – Time For Change?

  Maintaining a contamination-free environment is crucial in drug compounding. Learn how isolator systems can improve safety, efficiency, and regulatory compliance.

• Lower Punch Tip Bending / Buckling

  When manufacturing mini-tablets, adjusting punch force ratings is crucial to prevent bending or buckling. The Rankine-Gordon formula offers a safer force rating for microtip tooling.

• Seizing Market Share Pre-Patent Expiry: The Evolution Of A CDMO Partnership In Navigating A Paragraph IV ANDA Submission

  The dynamic pharmaceutical landscape demands agility and strategic foresight. Explore how leveraging a key partnership helped to overcome a looming patent expiry for a second-generation acne medication.

• Customized Release Through Dispersed Dosage Formats

  Typically, dosage format is based on the target product profile: how the developer envisions the product best addressing a clinical indication by maintaining population-wide efficacy.

• Tablet Consistency And Punch Length – A Pragmatic Perspective For European Manufacturers

  10/7/2025

  Tablet consistency relies on a balance of formulation, press mechanics, and tooling. Learn why punch length tolerance is often overstated and what other critical factors truly drive quality and uniformity.

• Die Bore Cracking: How To Achieve Reliable Tablet Production

  7/30/2024

  Die bore cracking is a significant issue in tablet manufacturing, affecting the quality of the tablets and potentially damaging the tablet press. Explore how to analyze for and prevent this damage.

• Improving API Solubility Using Hot Melt Extrusion Formulation

  2/27/2025

  Solubility of active pharmaceutical ingredients (APIs) is a challenge in drug development. Discover how hot melt extrusion with polyvinyl alcohol enhances API solubility and stability to offer improved drug delivery.

• The Crucial Role Of Cleaning In Effective VPHP Decontamination For Isolators

  12/27/2024

  Effective isolator cleaning is crucial for vapor phase hydrogen peroxide (VPHP) decontamination. Proper tools, techniques, and training ensure sterility, and regulatory compliance.

• The Role Of Quality By Design In Pharmaceutical Tablet Development

  7/30/2024

  Quality by Design (QbD) ensures efficiency and high standards in pharmaceutical tablet development. Explore how this proactive approach transforms manufacturing processes and enhances product quality.