INSIGHTS ON SOLID DOSE MANUFACTURING

SOLID DOSE MANUFACTURING SOLUTIONS

  • Bausch + Strobel SP-100 Powder filling Machine with control cabinet, stainless steel construction, with filler funnels and auger, serial# 51181, built 1998.

  • Sterility testing isolators with product protection for the sterility test under aseptic and optionally aseptic/toxic conditions. A Rapid Decon Hatch (RDH) can be connected as an option.

  • Find all the equipment used to make solid dose tablets and other compressed materials right here. Federal Equipment Company offers used tablet presses and equipment to fully complete the tablet manufacturing process – used rotary and single station tablet presses, used tablet dedusters, used friability testers, used hardness testers, used metal detectors, used tablet printers, and an assortment of used tablet press turrets and parts.

  • Used MG2 continuous motion capsule filler, model Planeta100, nominally rated up to 100,000 capsules/hour, currently set up for microdose capsules, multinet weight control unit less scale system, 460 volt, serial# 4697, built 2014.

  • Basic Powder Flow Characterization [USP <1174>]:

    A powder flow analysis is an indicator of how well formulation will release from the hopper during the tableting. It is important to know that the developed formulation is showing ‘Mass Flow’ or ‘Funnel Flow’ or ‘Rat Holing’.

    Powder blend shows ‘Mass Flow’ when the entire solid bed is in motion during the discharge of material from the outlet. This is a ‘First-in-First-Out’ process. Hoppers offering ‘Mass Flow’ have steep and/or low-friction walls. This flow offers ‘No-Arching’, ‘Less Segregation’, and ‘Stable Powder Flow’.

    When the hopper is not sufficiently steep and smooth enough to ensure sliding along its wall, the powder blend exhibit ‘Funnel Flow’. Such hoppers are sensitive to arching and ratholing. In this case, powder discharge from the hopper is not predictable.