INSIGHTS ON SOLID DOSE MANUFACTURING

• Optimizing Filling Technology To Minimize API Loss

  New advances in filling technology offer solutions that can minimize lost API and eliminate sources of risk while still meeting the regulatory requirements for testing and quality assurance.

• Aseptic Filling Of Dry Powder And Liquid In Dual Chamber Syringes

  The trend towards pre-filled disposable syringes whether of the single or dual chamber type is increasing. This webcast concentrates on the aseptic pharmaceutical packaging process challenges that need to be addressed in the final filling process of dual chamber syringes, where both liquid and powdery substances are mixed by the patient immediately prior to injection. This practice shows clear advantages as it can eliminate preservatives needs while enabling longer shelf lives.

• Product Development For An Oral Solid Dosage Using Continuous Manufacturing

  A thorough evaluation using several small-scale studies should be completed to help determine whether continuous or batch manufacturing is the best fit for your product.

• The Next Generation ODT

  Orally dissolving tablets (ODT) are designed to dissolve rapidly on contact with saliva, therefore eliminating the need to chew the tablet, swallow the intact tablet, or take the tablet with liquids. Zydis® ODT fast-dissolve formulation from Catalent is a unique, freeze-dried tablet that disperses instantly in the mouth in less than three seconds. View the webinar to get an overview of the Zydis ODT technology, including new ways to administer peptides and vaccines. The webinar also presents the highlights of the next generation ODT technology, Zydis Ultra which can provide a better solution in terms of improved taste masking, innovative functional coating and a wide range of applications from Rx to OTC.

• Considerations When Cleaning Your Tablet Presses & Tablet Tooling

  Implementing a cleaning procedure is essential to maintaining your tablet tooling and presses. Dirty tools cause tableting and product quality-related problems, such as sticking & picking. Keeping tools clean also decreases premature tool, turret and cam wear, and reduces the risk of product cross-contamination. While most cleaning methods can achieve similar results, utilizing an automated cleaning system, such as an ultrasonic wash with rinse and dryer, can ensure tooling is properly cleaned and dried consistently with limited handling and potential for damage. A warm air-drying process is ideal for preventing moisture and corrosion by pushing warm air through areas, such as key slots, punch cups, and die bores, that may not be dried properly with a traditional towel or cloth.

• Fluid Bed Granulation And Melt Granulation In Pharma Manufacturing

  Affording superior reproducibility and control than other granulation techniques, fluid bed granulation and melt granulation can be tightly regulated to produce uniform material with a specified particle size.

• Technical Considerations For Developing Oral Solids (Part 1)

  Navigating your oral solids project from development through commercial manufacture can be a challenging path. In a two-part series, four oral solids experts from Pfizer CentreOne’s global network and partner organizations discuss the technical considerations to be aware of. In this first installment, we look at the importance of technical groundwork and understanding excipients in the early stages of your project.

• Shipping, Assembling, And Installing Bulky Exhaust Equipment In A Lab

  Though delivering, unloading, staging, and assembling are required steps in all lab construction, there are design aspects of lab equipment that can contribute to its successful field installation.

• How Can You Get Two Or Three APIs To Play Nice In One Capsule?

  Oral solid dose (OSD) delivery remains the most popular route for administering drugs. Market forces are prompting pharmaceutical companies to pursue a broad array of OSD development strategies to make their active pharmaceutical ingredients (APIs) and formulations therapeutically effective and patient friendly. One choice that is growing in popularity to control dose frequency and side-effects are compressed, tablet form multiple-unit pellet systems (MUPS).