INSIGHTS ON SOLID DOSE MANUFACTURING

• Ensuring Safe Handling Of High Potency Products

  Due to the high potency of the pharmaceutical active ingredients (APIs), machine operators have to be protected and while at the same time, humans are a high source for product contamination. In pharmaceutical manufacturing facilities, isolators are becoming increasingly important as they can achieve the desired level of protection and security. This article presents a fully integrated highly complex isolator and process equipment solution offering high safety, efficient control and cleaning features as well as full compliance in terms of manufacturing regulations.

• Flexible Isolator Technology – Containment That Works

  This webinar focuses on applications where flexible isolators have been used, including containment assessments to confirm performance and ergonomic benefits. 

• New Technologies For Safe And Contained Powder Handling In The Bulk Pharmaceutical Industry

  Powder handling plays a major role in the design and the operation of an API facility, and can often become the “bottle neck” of the plant. The constantly increasing toxicity and reactivity of products in recent years as well as the ever more demanding production standards with regard to quality have made closed powder handling an unavoidable factor and manual handling obsolete. Selecting a suitable technology has become vital for the development of a project since it can largely influence the entire design.

• Extrusion- Spheronization, Engineered For Today’s Controlled Release Forms

  Synchronizing and controlling API delivery, extrusion-spheronization offers pharmaceutical companies a robust technique to manufacture today’s most complex therapeutics. With the right capabilities, this well-understood process stands ready to help lead the development and manufacturing of both today’s and tomorrow’s complex OSD therapeutics.

• Managing Risks With Potent Pharmaceutical Products

  7/2/2019

  Any drug manufacturing facility handling potent compounds must be equipped with the appropriate methods, controls, and expertise to ensure the safety of its employees and the integrity of its product. Managing these risks requires a knowledgeable team as well as the design and implementation of an effective safety program.

• Drug Product Advancement - A Path Through Development By Powder In Capsule Approach

  5/11/2020

  Using micro-dosing technology and powder-in-capsule (PIC) or powder-in-bottle (PIB) approaches, biopharmaceutical companies can increase speed to clinic, quickly assess their candidate compounds, and remain cost-conscious in early stage development.  In this webinar, Lonza experts review best practices PIC and PIB challenges and discuss rapid encapsulation transfer from clinic to commercial scale.

• Enabling Enteric Protection And Rapid Release In The Upper Small Intestine

  10/5/2020

  Enteric coatings have been utilized with oral drug products for more than 60 years to protect acid-sensitive APIs from gastric acids and prevent gastric irritation by aggressive APIs. However, for many complex drug products targeting the small intestine or ileocolonic region, enteric protection on its own is insufficient to maximize absorption and enhance bioavailability. A new and unique oral drug delivery technology could be the solution.

• Five Tests For Pharmaceutical Containment

  3/13/2020

  As active pharmaceutical ingredients increase in potency and become more hazardous to work with, pharmacological and chemical containment devices are required to meet containment performance targets through independent testing before use in laboratories can begin. Typically, we test containment equipment against some minimum performance standard. This is necessary to protect procedural integrity and the sensitive products undergoing processing.

• Selection Criteria For Ribbon, Vertical, Or Tumble Blenders

  2/4/2020

  Among solid-solid blending systems, the three most common types are the horizontal ribbon blender, the cone screw vertical blender and the tumble blender. Aside from level of shear or ‘gentleness’, other factors help determine which type of blender will work most efficiently in a certain application. Following are some things to consider when choosing your blender.