INSIGHTS ON SOLID DOSE MANUFACTURING
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![White Tablets-GettyImages-172969989]( "Predicting Drug-Loading Limits In Tablet Formulations")
Predicting Drug-Loading Limits In Tablet FormulationsLearn how predictive percolation modeling identified critical drug-loading limits of ~20% for crystalline API and ~15% for SDD forms, cutting tablet formulation trial-and-error significantly.
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![Natoli - tool and tablet]( "Tablet Consistency And Punch Length – A Pragmatic Perspective For European Manufacturers")
Tablet Consistency And Punch Length – A Pragmatic Perspective For European ManufacturersTablet consistency relies on a balance of formulation, press mechanics, and tooling. Learn why punch length tolerance is often overstated and what other critical factors truly drive quality and uniformity.
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![Dalton photo 2]( "How To Handle Intrinsic Product Powder Particles")
How To Handle Intrinsic Product Powder ParticlesPowder filling creates intrinsic particles that interfere with continuous monitoring. Risk‑based strategies must separate product dust from true contamination to meet Annex 1 requirements.
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![GettyImages-950086574-microscope-scientist-pill-development]( "Minitablets: Enhancing Safety And Palatability For Pediatric Medicines")
Minitablets: Enhancing Safety And Palatability For Pediatric MedicinesLeverage minitablet technology to create flexible, easy-to-swallow, and palatable pediatric formulations that improve adherence and meet evolving regulatory requirements.
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Rheological Properties Of Pharmaceutical Excipients: Lactose Monohydrate And Carboxymethyl Cellulose12/30/2024
Explore lactose monohydrate and CMC rheology, highlighting their flow, cohesion, and compressibility properties to optimize pharmaceutical formulations under varying stress and temperature conditions.
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Layer By Layer: 3D Screen Printing And The Future Of Drug Development8/15/2025
3D screen printing can produce tablets across a range of release profiles, from conventional immediate release tablets to multi-compartment drug delivery systems that mix different release profiles.
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Overcoming The Obstacles Of Spray-Dried Dispersion Scale-Up9/9/2026
SDD scale-up introduces scale-dependent risks that threaten bioavailability, stability, and manufacturability. This white paper details a model-based framework for managing those risks from early feasibility through commercial production.
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Innovations In Orally Disintegrating Tablets For Pediatric Drug Delivery1/27/2025
Delve into the evolving landscape of pediatric dosage forms, with a focus on how ODTs are emerging as a specialized and practical drug delivery system for children.
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A Vibrating Capillary System Enables Fully Automatic Dosing For Powders8/29/2026
Weight-controlled vibrating capillary technology provides precise microgram powder dosing into capsules or vials while maintaining full operator containment.
SOLID DOSE MANUFACTURING SOLUTIONS
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![GettyImages-2195598151 copy]( "Considerations For Paediatric Drug Development")
Paediatric drug development demands careful attention to dosing, taste, stability, dosage form design, and regulatory requirements to ensure safe, effective therapies.
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![iStock-1191001266-tablet-pill]( "Oral Solid Dose Formulation Troubleshooting Support Services")
Natoli organization is a reputed leader with more than a half century experience in the tablet manufacturing technology.
We understand tablets better. We are here for serving your needs to overcome challenges associated with commercial manufacturing of solid dosage forms across the globe (North America, Europe, Asia).
Our Natoli scientific team uses holistic approach to understand and solve important tableting problems like capping, lamination, picking, and sticking. We integrate scientific information gathered at material, process, and instrument level to understanding and decode root causes of these common tableting issues.
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The big bag emptying stations of Dec are based on a modular design. This allows to be ideally equipped with systems for each product’s characteristics with corresponding docking systems for non-potent to highly active powders. Depending on the product flow, there is a range of discharge devices or lump breakers available. With the use of load cells, it is possible to dose accurately into the receptacle.
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![Aseptic-processing-isolator]( "Aseptic Processing Isolator (Filling-Lyophilization) From Franz Ziel")
Isolators with product protection as a housing for aseptic processes, e.g. filling, loading and unloading of freeze dryers.
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![ssp2]( "Small-Scale Automatic Micro-Dosing Of Powders Into Blisters")
Optimize small- to medium-scale inhalation blister strip production with flexible powder filling technology, integrated operator containment, and automated quality verification.
