INSIGHTS ON SOLID DOSE MANUFACTURING
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![Pharm Manufacturing Facility GettyImages-1087218874]( "Die Bore Cracking: How To Achieve Reliable Tablet Production")
Die Bore Cracking: How To Achieve Reliable Tablet ProductionDie bore cracking is a significant issue in tablet manufacturing, affecting the quality of the tablets and potentially damaging the tablet press. Explore how to analyze for and prevent this damage.
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![GettyImages-537472967 pharmaceutical, pills, medicine]( "How High Drug Load Nanocrystalline Tablets Lower Pill Burden")
How High Drug Load Nanocrystalline Tablets Lower Pill BurdenWe showcase the development of high drug load nanocrystal based tablets and prove that nanocrystals can match the pharmacokinetic performance of ASDs while reducing the overall pill burden.
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![Pharmaceutical technology-GettyImages-1137680279]( "Developing And Manufacturing Drugs With HPAPIs")
Developing And Manufacturing Drugs With HPAPIsLearn why companies must invest in specialized expertise to develop scalable, safe, and efficient manufacturing processes for highly potent oral solid dose products.
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![GettyImages-2151878896_carboxymethyl-cellulose]( "Rheological Properties Of Pharmaceutical Excipients: Lactose Monohydrate And Carboxymethyl Cellulose")
Rheological Properties Of Pharmaceutical Excipients: Lactose Monohydrate And Carboxymethyl CelluloseExplore lactose monohydrate and CMC rheology, highlighting their flow, cohesion, and compressibility properties to optimize pharmaceutical formulations under varying stress and temperature conditions.
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How To Solve Complex Pediatric Dosing Challenges Using Tailored Solutions8/11/2025
With a partner who understands the science, the regulations, and the real-world demands of dosing children, development can move faster, smarter, and with greater confidence
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Concept To Market: Scaling And Manufacturing Semi-Solid Topical Drugs2/23/2026
Learn how formulation, processing, and scale‑up choices impact the stability, structure, and performance of semi‑solid topicals while ensuring consistent quality through development.
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Less Mess, Less Stress, Best Expressed: An Alternative To Spray Drying7/16/2024
Although well-established processes, spray drying and hot-melt extrusion can be outperformed in bioavailability, cost-savings, manufacturing speed, environmental impact, and more.
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Round Tablet Compression Tooling — To Key Or Not To Key The Punches7/30/2024
What makes the keying in tablet compression tooling, specifically in tablet punches, so important to the tablet manufacturing processes?
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Tablet Consistency And Punch Length – A Pragmatic Perspective For European Manufacturers10/7/2025
Tablet consistency relies on a balance of formulation, press mechanics, and tooling. Learn why punch length tolerance is often overstated and what other critical factors truly drive quality and uniformity.
SOLID DOSE MANUFACTURING SOLUTIONS
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![Quick-Release Pharmaceutical Tablet Tooling]( "Quick-Release Pharmaceutical Tablet Tooling")
Natoli Quick-Release Tablet Tooling allows researchers to test different dwell times during the tablet R&D process without the expense of buying several different sets of tools or the time needed to change complete sets of tooling or turret speed.
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![Elizabeth Hata Tablet Press]( "Used Elizabeth Hata 65 Station Tablet Press")
Used Elizabeth Hata HT-X65LD-U Tablet Press, 65 Station, BB-tooling, 8 ton pre and main compression, Keyed Upper Punch Guide, Dual Sided, Force Feeders, 13MM max tablet diameter, 18MM max depth of fill, 624,000 max TPH output, Feed hopppers, Control Panel, S/N: 2038.
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![PHARMACEUTICAL CONTRACT PACKAGING AND FILLING SERVICES]( "Pharmaceutical Contract Packaging And Filling Services")
With ample available capacity, Ropack Pharma Solutions provides the efficiency of five bottling lines with quick changeovers, online validated fill accuracy and the flexibility to accommodate small lots to commercial runs for the bottling of tablets, capsules and powders.
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![iStock-870087778-powder]( "Powder Flow Properties & Characterization Services")
Basic Powder Flow Characterization [USP <1174>]:
A powder flow analysis is an indicator of how well formulation will release from the hopper during the tableting. It is important to know that the developed formulation is showing ‘Mass Flow’ or ‘Funnel Flow’ or ‘Rat Holing’.
Powder blend shows ‘Mass Flow’ when the entire solid bed is in motion during the discharge of material from the outlet. This is a ‘First-in-First-Out’ process. Hoppers offering ‘Mass Flow’ have steep and/or low-friction walls. This flow offers ‘No-Arching’, ‘Less Segregation’, and ‘Stable Powder Flow’.
When the hopper is not sufficiently steep and smooth enough to ensure sliding along its wall, the powder blend exhibit ‘Funnel Flow’. Such hoppers are sensitive to arching and ratholing. In this case, powder discharge from the hopper is not predictable.
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![Powder Rheology Feature]( "Discovery Hybrid Rheometers: Temperature Systems And Accessories")
Explore a wide variety of DHR temperature systems and accessories, designed for superior performance and ease-of-use.
