INSIGHTS ON SOLID DOSE MANUFACTURING
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![GettyImages-1370967510 hot cold]( "Overview Of Hot Melt Extrusion And Its Pharmaceutical Applications")
Overview Of Hot Melt Extrusion And Its Pharmaceutical ApplicationsMore than 40% of NCEs face aqueous solubility challenges. Here, we examine how hot melt extrusion addresses solubility, modified release, abuse deterrence, and scale-up across pharmaceutical development.
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![GettyImages-1087219370-fill-finish-aseptic-manufacturing]( "Future-Proofing Aseptic Manufacturing")
Future-Proofing Aseptic ManufacturingInvesting in adaptable aseptic manufacturing pays off. Find out how flexible systems, despite higher initial costs, handle complex drugs and changing volumes to boost productivity and quality.
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![GettyImages-2024513353 drug manufacturing]( "An Alternative Method Of Drug-Excipient Characterization")
An Alternative Method Of Drug-Excipient CharacterizationIsothermal microcalorimetry (IMC) rapidly screens API-excipient compatibility, detecting physical and chemical interactions faster than conventional methods, saving time and effort in pharmaceutical formulation development.
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![3P innovation - achieving licensing]( "Achieving Licensing For A Healthcare Solution")
Achieving Licensing For A Healthcare SolutionFacing strict regulations and tricky powders, a healthcare client sought an advanced filling solution. Learn how an expert collaboration led to licensed product, boosting precision and productivity.
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The Crucial Role Of Cleaning In Effective VPHP Decontamination For Isolators12/27/2024
Effective isolator cleaning is crucial for vapor phase hydrogen peroxide (VPHP) decontamination. Proper tools, techniques, and training ensure sterility, and regulatory compliance.
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Rheological Properties Of Pharmaceutical Excipients: Lactose Monohydrate And Carboxymethyl Cellulose12/30/2024
Explore lactose monohydrate and CMC rheology, highlighting their flow, cohesion, and compressibility properties to optimize pharmaceutical formulations under varying stress and temperature conditions.
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Beyond Development: Using Continuous Manufacturing To Accelerate OSD Commercialization8/31/2026
Hear firsthand insights from Douglas B. Hausner, Ph.D., Senior Manager of Continuous Manufacturing, on the company’s first OSD product submission enabled by continuous manufacturing and Real-Time Release Testing.
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Isolators For Pharmacy Compounding – Time For Change?3/14/2025
Maintaining a contamination-free environment is crucial in drug compounding. Learn how isolator systems can improve safety, efficiency, and regulatory compliance.
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How To Avoid Sticking And Picking In The Tableting Industry9/23/2024
Review strategies to mitigate sticking and picking risks in the tablet industry, and learn how you can foster improved tablet production processes, ensuring higher quality and consistency.
SOLID DOSE MANUFACTURING SOLUTIONS
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![Used Pharmaceutical Tablet Presses]( "Used Pharmaceutical Tablet Presses")
Find all the equipment used to make solid dose tablets and other compressed materials right here. Federal Equipment Company offers used tablet presses and equipment to fully complete the tablet manufacturing process – used rotary and single station tablet presses, used tablet dedusters, used friability testers, used hardness testers, used metal detectors, used tablet printers, and an assortment of used tablet press turrets and parts.
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![Natoli scientists]( "Pharmaceutical Preformulation Support Services")
Partner with Natoli Scientific during the earliest stages. Our scientific expertise with state-of-the-art analytical capabilities is ready to take any preformulation challenge.
Natoli scientific has an expertise of handling a wide range of APIs for the development of oral solids. We apply principles of ‘Quality by Design’ to define Critical Material Attributes (CMA), Critical Process Parameters (CPP), Critical Quality Attributes (CQA) and Quality Target Product Profiles (QTPP). Because we believe that understanding material and process as much as possible in the early life cycle of drug product development program is an insurance for further development path. Keeping your practices up to date with the ICHQ8 regulatory guidance issued by the US FDA. This is also a gate way for a smooth ride of product in the different stages of product development stages.
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![ILC Dover Continuous Liner]( "Continuous Liner Containment For Pharmaceutical And Biopharma Powders")
The ILC Dover Continuous Liner is an easy-to-use system that has been proven effective in containing active pharmaceutical ingredients and other hazardous compounds.
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![NP-P20A]( "Single-Station Hydraulic Pharmaceutical Tablet Press: NP-P20A")
Natoli Engineering’s NP-P20A single-station hydraulic tablet press is a favorite for the production of injectable micropellets and for marginal formulations requiring deep-fill. The NP-P20A meets the FDA’s requirements for batch reporting and secure data management under CFR 21 Part 11 compliance.
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![iStock-870087778-powder]( "Powder Flow Properties & Characterization Services")
Basic Powder Flow Characterization [USP <1174>]:
A powder flow analysis is an indicator of how well formulation will release from the hopper during the tableting. It is important to know that the developed formulation is showing ‘Mass Flow’ or ‘Funnel Flow’ or ‘Rat Holing’.
Powder blend shows ‘Mass Flow’ when the entire solid bed is in motion during the discharge of material from the outlet. This is a ‘First-in-First-Out’ process. Hoppers offering ‘Mass Flow’ have steep and/or low-friction walls. This flow offers ‘No-Arching’, ‘Less Segregation’, and ‘Stable Powder Flow’.
When the hopper is not sufficiently steep and smooth enough to ensure sliding along its wall, the powder blend exhibit ‘Funnel Flow’. Such hoppers are sensitive to arching and ratholing. In this case, powder discharge from the hopper is not predictable.
