It is common for tablet manufacturers to exceed the maximum compression force ratings of their tooling to form a quality tablet. However, going beyond the prescribed tooling rating may result in premature tool wear or failure and possible damage to the press. With proper formulation development and tablet design, the tablet press operator should be able to manufacture quality tablets without exceeding the tooling’s maximum compression force rating.
While media and buffer materials have been notorious contributors to airborne particulates and contamination in the past, they don’t have to be.
Identifying the source of product flow problems and correcting them with the right piece of equipment will result in more efficient and quality manufacturing.
Finding the right mixing equipment isn’t as simple as selecting an item from a menu. This article is a guide to considerations when choosing pharmaceutical mixing equipment and vendors for a facility.
While there are “bad” fume hoods, anything wrong with the entire system (exhaust fan, ductwork, building configuration, regulative dampers) may cause a lack of containment in a hood.
Single-use transfer technology has been used in biopharma manufacturing for years. However, upstream powder-handling processes haven’t been improved upon. Now, the industry is seeing a need for better ways to bring powders to the hydration process and begin upstream biologic manufacturing.
Don’t risk operator exposure and potential contamination with untested or unproven single-use valve technologies.
Rapid non-destructive headspace moisture analysis from LIGHTHOUSE enables fast moisture determination of statistical numbers of lyo samples.
Sticking or picking issues are often not detected until transferring the product from research and development to production. Prevent unanticipated problems during scale up and full-scale production by considering tablet compression issues before tablet designs are finalized.
Used 100 liter Sartorius Stedim fermentor, 316L stainless steel product contact surfaces with 100 liter vessel rated 50 psi and full vacuum at 350 internal, jacketed for 100 psi and full vacuum at 350 f, bottom mounted agitator drive with mechanical seal, skid mounted with valving, HMI and controls, vessel certified by Walker Stainless, serial# 2204-100A, national board# 5179, Sartorius Stedim serial# , built 2003.
The pneumatic POSITIVE pressure conveying (or PRESSURE conveying) is dedicated to the transfer of larger quantities of powder or granulates under following conditions:
Natoli Engineering Company, through its Carlisle Precision Encapsulation Parts subsidiary, manufactures premium change and spare parts for many brands of encapsulation machines.
Used 57" Applied Containment Engineering isolator, stainless steel construction, approximately 57" wide x 19" deep x 32" high chamber, singled sided, (3) glove ports, with integrated Mettler Toledo scale with digital readout, 9.5" diameter side pass thru, provision for back mounted drum dump feed on legs, serial# C2261/A/001/06, built 2006.
Fast powder mixing solution with complete protection of powder properties.