INSIGHTS ON SOLID DOSE MANUFACTURING

• Overcoming The Obstacles Of Spray-Dried Dispersion Scale-Up

  SDD scale-up introduces scale-dependent risks that threaten bioavailability, stability, and manufacturability. This white paper details a model-based framework for managing those risks from early feasibility through commercial production.

• Tablet Consistency And Punch Length – A Pragmatic Perspective For European Manufacturers

  Tablet consistency relies on a balance of formulation, press mechanics, and tooling. Learn why punch length tolerance is often overstated and what other critical factors truly drive quality and uniformity.

• Solubility And Improved Patient Outcomes

  Poor solubility poses major development challenges. Innovative formulation technologies and careful excipient selection can improve bioavailability and product performance.

• An Alternative Method Of Drug-Excipient Characterization

  Isothermal microcalorimetry (IMC) rapidly screens API-excipient compatibility, detecting physical and chemical interactions faster than conventional methods, saving time and effort in pharmaceutical formulation development.

• Rheological Properties Of Pharmaceutical Excipients: Lactose Monohydrate And Carboxymethyl Cellulose

  12/30/2024

  Explore lactose monohydrate and CMC rheology, highlighting their flow, cohesion, and compressibility properties to optimize pharmaceutical formulations under varying stress and temperature conditions.

• Achieving Manufacturing Efficiency In OSD Manufacturing

  10/16/2024

  Gain expert insight into the importance of instrumented tablet presses in assessing formulation properties, the role of tablet cup configurations, and scalability parameters for successful product transfer.

• Why Spray Drying Is Gaining Attention

  7/20/2026

  Facing patent cliffs, pharma companies can leverage spray drying to reformulate complex biologics, enabling non-invasive delivery, boosting patient convenience, and securing new patents.

• HPAPI Containment: A Full Lifecycle Safety Innovation

  6/15/2026

  Containing highly potent APIs across a full operational lifecycle requires a structured approach that addresses hazard scoring, quality by design, performance testing, and safe enclosure disposal.

• The Importance Of Polymorph Screenings

  5/6/2026

  Discover how systematic polymorph screening reduces development risk, safeguards product performance, and enables confident solid‑form selection across the drug development lifecycle.