INSIGHTS ON SOLID DOSE MANUFACTURING
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Spray Dry Biologics For Oral Dosage Forms
Spray drying enables stable oral delivery of biologics by creating protective dry powders, improving bioavailability, stability, and targeted release compared with traditional formulation methods.
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Safely Scaling High Potency API Manufacturing
Scaling HPAPI production demands disciplined containment and exposure control. Integrated operating models help manage risk while enabling compliant, reliable scale‑up.
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Innovations, Solutions, And USP <1062> With Scale Up
Optimize tablet compression by simplifying calibration, speeding up changeovers, and utilizing advanced laser inspection to prevent critical punch tip wear and maintain quality.
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Improving API Solubility Using Hot Melt Extrusion Formulation
Solubility of active pharmaceutical ingredients (APIs) is a challenge in drug development. Discover how hot melt extrusion with polyvinyl alcohol enhances API solubility and stability to offer improved drug delivery.
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Automated Precision Powder Filling For Annex 11/21/2026
Aseptic powder filling is complex, demanding automation and isolator‑based, weight‑controlled dosing to ensure sterility and accuracy.
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FastLok™ Die Table Surface Overview10/8/2025
Learn about a toolless, removable surface that allows for rapid, on-turret plate replacement in minutes, not weeks, significantly improving operational efficiency.
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Overload Setting – Tricks And Techniques9/23/2024
Learn how a partner company that is committed to assisting manufacturers with calibration and optimal set-point establishment can serve as a valuable resource in achieving optimal tablet production.
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GLP-1 OSD Chemical Synthesis Workflow6/29/2026
Enhance containment and process reliability in oral GLP-1 synthesis. Discover how integrated single-use assemblies and automated fluidics safeguard chemical purity during scale-up.
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Advancements In GLP-1 Analog Formulation: Overcoming Challenges2/3/2025
Oral GLP-1 formulations represent a groundbreaking advance in obesity treatment to offer improved patient comfort and adherence while expanding the therapeutic market.
SOLID DOSE MANUFACTURING SOLUTIONS
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Natoli Engineering’s NP-P20A single-station hydraulic tablet press is a favorite for the production of injectable micropellets and for marginal formulations requiring deep-fill. The NP-P20A meets the FDA’s requirements for batch reporting and secure data management under CFR 21 Part 11 compliance.
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Hata Tablet Press, Model HT-AP55-DU/I.E. Double sided, serial number Nov. 90 - Oct. 1991
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Isolators with product protection as a housing for aseptic processes, e.g. filling, loading and unloading of freeze dryers.
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Our Rigid Stainless Steel Containment Isolators have been designed for handling potent compounds that can offer guaranteed levels of operator protection as low as 10ng/m3 (task duration). These include designs for sampling, dispensing and sub-division, mixing, milling and vessel charging, as well as containing integrated process devices such as filter dryer units, tablet press enclosures, blenders, mills and pack off systems.
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Dec provide custom designed isolators for dispensing and/or sampling from various containers such as bags and drums into intermediate packaging or for direct charging into process equipment. These systems offer high containment and a controlled environment offering fast cleaning and drying features allowing for swift product changes.