INSIGHTS ON SOLID DOSE MANUFACTURING

SOLID DOSE MANUFACTURING SOLUTIONS

  • Our Rigid Stainless Steel Containment Isolators have been designed for handling potent compounds that can offer guaranteed levels of operator protection as low as 10ng/m3 (task duration). These include designs for sampling, dispensing and sub-division, mixing, milling and vessel charging, as well as containing integrated process devices such as filter dryer units, tablet press enclosures, blenders, mills and pack off systems.

  • Over many years, Dec has acquired recognized expertise in designing and supplying an extensive range of isolators enclosing a mill or a MC DecJet® spiral jet mill for either individual or combined operation.

  • Secure your laboratory environment when handling infectious materials. High-containment systems provide leak-tight protection for BSL 2+ through 4 applications, ensuring operator safety.

  • Basic Powder Flow Characterization [USP <1174>]:

    A powder flow analysis is an indicator of how well formulation will release from the hopper during the tableting. It is important to know that the developed formulation is showing ‘Mass Flow’ or ‘Funnel Flow’ or ‘Rat Holing’.

    Powder blend shows ‘Mass Flow’ when the entire solid bed is in motion during the discharge of material from the outlet. This is a ‘First-in-First-Out’ process. Hoppers offering ‘Mass Flow’ have steep and/or low-friction walls. This flow offers ‘No-Arching’, ‘Less Segregation’, and ‘Stable Powder Flow’.

    When the hopper is not sufficiently steep and smooth enough to ensure sliding along its wall, the powder blend exhibit ‘Funnel Flow’. Such hoppers are sensitive to arching and ratholing. In this case, powder discharge from the hopper is not predictable.

  • Used Pharma Packaging System bottle filling line consisting of: - Accumulation feed table, stainless steel construction. -Pharma Packaging Systems lane counter, model 8-1 Vitacount, (8) lane, stainless steel product contact surfaces, single filling station, with reject, with HMI touch screen, 230 volt, 50 Hz, serial# PPS 544, built 2013. -Accumlation discharge table, stainless steel construction, -Domino A420i coder, serial# AST00117225, -Enercon induction sealer, model Super Seal.