INSIGHTS ON SOLID DOSE MANUFACTURING
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Layer By Layer: 3D Screen Printing And The Future Of Drug Development
3D screen printing can produce tablets across a range of release profiles, from conventional immediate release tablets to multi-compartment drug delivery systems that mix different release profiles.
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Lower Punch Tip Bending / Buckling
When manufacturing mini-tablets, adjusting punch force ratings is crucial to prevent bending or buckling. The Rankine-Gordon formula offers a safer force rating for microtip tooling.
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GLP-1 OSD Chemical Synthesis Workflow
Enhance containment and process reliability in oral GLP-1 synthesis. Discover how integrated single-use assemblies and automated fluidics safeguard chemical purity during scale-up.
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Innovations, Solutions, And USP <1062> With Scale Up
Optimize tablet compression by simplifying calibration, speeding up changeovers, and utilizing advanced laser inspection to prevent critical punch tip wear and maintain quality.
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The Future Of Sustainable Amorphous Dispersion Development4/15/2026
Sustainable amorphous dispersion cuts cost, risk, and timelines by removing solvent waste, simplifying manufacturing, strengthening supply chains, and scaling efficiently to commercialization.
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De-Risking Production Of Complex Oral Solid Dosages: Considerations & Key Capabilities7/13/2026
Reduce formulation and scale-up risk with integrated development and manufacturing expertise for complex OSD products.
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Isolators For Pharmacy Compounding – Time For Change?3/14/2025
Maintaining a contamination-free environment is crucial in drug compounding. Learn how isolator systems can improve safety, efficiency, and regulatory compliance.
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Cytiva's Aseptic Filling Workcell User Group1/9/2026
Discover how global collaboration among aseptic filling experts is driving innovation and improving operations.
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Advancing High Potency Manufacturing4/13/2026
Advance potent drug manufacturing through tighter containment, thoughtful process engineering, and closed handling that protects workers while improving efficiency and scale.
SOLID DOSE MANUFACTURING SOLUTIONS
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The pharmaceutical OSD manufacturing sector typically includes the final formulation to produce tablets and capsules, so the need to meet the current Good Manufacturing Practice (cGMP) regulations and quality standards is paramount.
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Used Fuji Paudal Marumerizer spheronizer, model QJ700, stainless steel construction, with 2.0 mm grooved spheronizing plate with plate lift mechanism, jacketed bowl, side discharge with pneumatically operated plug valve, on base, serial 20050, built 1990.
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Enhance dissolution and lubrication in solid oral formulations. See how this approach supports poorly soluble actives, modern manufacturing methods, and consistent performance.
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Now you can upgrade to Natoli’s premium segmented turret for your Fette Press! Natoli Engineering has 20 years’ experience in manufacturing segments, backed by ongoing investments in advanced R&D, CNC process automation, and precision finishing which meets often surpasses the OEM - Our quality is in the detail. The Fette patent is now expired, and Natoli is ready to deliver unmatched quality and performance.
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When AST came to the table on the design for our new fill-finish isolator, one of the first areas AST engineers wanted to address was the usability and accessibility of the isolator and corresponding operations. With our customers’ point of view in mind, we wanted to address specific points of friction routinely encountered by operators and closely examine whether those friction points were necessary.
Does an isolator need to be ergonomically unfriendly to clean?
Should simple mechanisms like isolator doors be challenging to engage? (As much as one can appreciate exercise, no one wants to do “arm day” in cleanroom coveralls).
Does routine maintenance have to be time-consuming and laborious?
Many of these factors are accepted as par for the course in aseptic fill-finish manufacturing. Our question was, why?