FEATURE ARTICLES
Though methotrexate is the most effective therapeutic against primary central nervous system (CNS) lymphoma, it can cause toxicity issues at therapeutic concentrations. Aditi Suchitkumar Satoskar and her research team at Mercer University sought to look for alternatives, investigating a noninvasive approach that combines methotrexate-loaded bovine serum albumin nanoparticles, an RVG-derived brain-targeting peptide, and a 3D-printed buccal film.
- Why We Need Pharmaceutical Engineering Project Management As A Distinct Discipline
- Your 7 Decisions To Make Before MES Configuration
- The Orange Book's Blind Spot: Process Stability And Capability
- Are You Falling Behind On Intelligent Pharmaceutical Manufacturing?
- Qualification And Validation Of Depyrogenation Tunnels And Autoclaves
- DEA Reveals Hidden Costs Of Analytical Validation Guidelines
- Why CMC Tech Transfer Should Begin With The End In Mind
PHARMA ONLINE WHITE PAPERS
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![Simplifying-Adenoviral-Purification-GettyImages-1407089058]( "Simplifying Adenoviral Purification For Scalable Manufacturing")
Simplifying Adenoviral Purification For Scalable ManufacturingAs vector design advances, downstream purification limits adenoviral manufacturing. A membrane-integrated hybrid train reduces product loss and process complexity at scale.
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From Open Cleanrooms To Closed Systems – What Is Driving The Change?3/14/2025
Aseptic processing is evolving. Regulatory changes and technological advancements are driving a shift from open cleanrooms to closed systems for sterile drug manufacturing.
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FDA's Regenerative Medicine Advanced Therapy (RMAT) Program12/10/2025
RMAT qualification requires preliminary clinical evidence demonstrating the potential to address an unmet medical need. This designation grants benefits like intensive guidance and faster FDA review.
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Transformative Innovation: Advancing Drug Development Using In Silico Modeling3/4/2026
Explore how predictive modeling and in silico strategies can turn complex data into actionable insights that accelerate drug development and reduce risk across the development lifecycle.
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Quality Assurance In IVT RNA Vaccine Development Using Electrophoresis2/20/2025
Discover advanced solutions for IVT RNA synthesis, focusing on enhancing fidelity in throughput, innovative technologies, and methodologies to optimize your RNA research and development processes.
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Exploring Agentic AI In GMP Operations8/12/2025
Discover how agentic AI is poised to transform Enterprise Asset Management in regulated industries to enhance compliance, reduce downtime, and bridge fragmented systems for resilient operations.
PHARMA ONLINE APP NOTES & CASE STUDIES
- 3D Screen Printing: Enabling A New Generation Of Complex Formulations
- Validation Provider Shortens The Path To Equipment Qualification
- Improving API Solubility Using Spray Drying With Polyvinyl Alcohol
- Transforming Development Through Mass Spectrometry Data Analysis
- Automation-Assisted Washing Of Multicellular 3D Spheroids
NEWSLETTER ARCHIVE
- 10.20.26 -- AI Innovation Is Transforming Drug Development And Manufacturing
- 10.20.26 -- Are You Falling Behind On Intelligent Pharmaceutical Manufacturing?
- 10.20.26 -- Reduce risk. Move Annex 1 forward.
- 10.20.26 -- Could Today's Development Decisions Create Tomorrow's Risks?
- 10.19.26 -- Strengthen Product Quality With Smarter Inspection and Testing Strategies
INDUSTRY NEWS
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![white coupon banner, great topic-GettyImages-2271702407]( "Let Your Voice Help Shape Pharma Manufacturing")
Let Your Voice Help Shape Pharma ManufacturingPharmaceutical Online hosts live virtual panels with industry experts on important topics and challenges, and we want to know what topics are important to you. Please consider taking a few minutes of your time to tell us what they are.
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![rating service, satisfaction-GettyImages-2221603596]( "ISPE Announces 2026 FOYA Winners")
ISPE Announces 2026 FOYA WinnersThese awards recognize pharmaceutical and biopharmaceutical manufacturing projects that demonstrate excellence across innovation, operations, supply chain, Pharma 4.0, and social impact.
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![FDA Logo on phone screen-GettyImages-2208861549]( "Høeg In, Pazdur Out At The FDA")
Høeg In, Pazdur Out At The FDAWhat an eventful week it has been at the FDA, with Richard Pazdur, M.D., resigning after weeks in his position as director of Center for Drug Research and Evaluation (CDER), and his vacancy being quickly filled by acting director Tracy Beth Høeg, M.D.
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![business peope negotiating-GettyImages-637902194]( "9 Drugs Granted Fast Track By FDA's Voucher Program")
9 Drugs Granted Fast Track By FDA's Voucher ProgramWith targets like pancreatic cancer, deafness, blindness, infertility and vaping addiction, these drugs were chosen due to an unmet need, addressing a public health crisis, boosting domestic manufacturing or increasing affordability.
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![Pharmaceutical sorting machine, pills-GettyImages-1499814881]( "Leaders In The Excipient Market: Region And Type")
Leaders In The Excipient Market: Region And TypeThough North America led the market with a 38.32% market share of $3.15 billion in 2024, Asia Pacific is expected to have the fastest growth in the upcoming years.
PHARMACEUTICAL ONLINE CONTENT COLLECTIONS
Explore how sterility assurance, including sterilization validation and environmental monitoring, is essential for controlling microbial contamination in mammalian cell production to ensure patient safety. Check out the latest e-book from Pharmaceutical Online.
More Content CollectionsSUPPLIER NEWS
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MVIC And Upperton Pharma Solutions Announce Strategic Collaboration10/20/2026
MVIC (Medicon Valley Inhalation Consortium) and Upperton Pharma Solutions today announced a strategic collaboration designed to provide pharmaceutical and biotech companies with a seamless, end-to-end solution spanning early discovery, formulation development, preclinical support, and clinical trial manufacturing.
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Hapman To Unveil New Conveying Solution At PACK EXPO 202610/15/2026
Hapman, a global leader in custom built bulk material handling equipment, will exhibit at PACK EXPO 2026, taking place October 18–21, 2026, in Chicago, Illinois. Attendees are invited to visit Hapman at Booth LU-7258 to explore the Bulk Bag Filler, Helix® Flexible Screw Conveyor, Bulk Bag Unloader, and CablePro™ Tubular Drag Conveyor.
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Pharmaceutical Online Covers Honorable Mention FOYA Award Winner, Chugai Pharmaceutical Co., Ltd.10/13/2026
Chugai Pharmaceutical Co., Ltd. is advancing pharmaceutical manufacturing through extensive automation at its FJ3 active pharmaceutical ingredient (API) production facility, a project that was recently recognized with a 2026 ISPE Facility of the Year Awards (FOYA) Honorable Mention.
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Emerson Expands Life Sciences Scheduling Software To Optimize Quality Control Lab Testing10/13/2026
Global automation leader Emerson today announced an enhancement to its DeltaV™ Real-Time Scheduling (RTS) software that extends integrated, real-time manufacturing scheduling capabilities to quality control (QC) labs.
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GSK Announces Drug Manufacturing Expansion In Pennsylvania10/13/2026
Today, Governor Josh Shapiro and Department of Community and Economic Development (DCED) Secretary Rick Siger announced the Commonwealth has secured an over $800 million investment from global biopharma company GSK to expand its operations in Montgomery County. The expansion will create more than 300 new jobs over the next five years, retain approximately 4,500 existing full-time jobs across the Commonwealth, and continue growing Pennsylvania’s robust life sciences industry.
