Application Notes & Case Studies

  1. High Sequence Coverage And Confident PTM Analysis Of Biotherapeutics Using An EAD-Based Workflow 9/21/2023

    Explore how a streamlined, EAD-based middle-down workflow can achieve consistent high sequence coverages of mAb subunits and confident PTM analysis in a single injection.

  2. Monitoring And Determining The Cause Of Antibody Discoloration Using cIEF And EAD 9/21/2023

    View a study which provides additional insight into the factors that govern the discoloration of protein therapeutics and the role of AGEs in color change.

  3. EAD-Based Middle-Down Workflow Analysis 9/21/2023

    How can a single-injection, EAD-based middle-down workflow leverage accurate mass measurement, information-rich EAD fragmentation and automated data analysis to offer confident sequence confirmation.

  4. CE-SDS Analysis Of Etanercept Using The BioPhase 8800 System 9/21/2023

    In this study, a system with multi-capillary capabilities was used to analyze etanercept by bapillary electrophoresis-sodium dodecyl sulfate (CE-SDS).

  5. CAPA Management Improvement Process 9/15/2023

    Gain insight into how a small team of experts worked to collect, trend, and understand the CAPA generation and completion process of a client struggling with on-time batch release, missed CAPA closure deadlines, and more.

  6. Accurate HC-LC Pairing And A Close-To-Nature Solution For bsAbs 9/11/2023

    Examine how a proprietary technology ensures high levels of accurate HC-LC pairing without detriment to critical quality attributes such as titer, binding affinity, stability, and immunogenicity.

  7. mRNA-LNP Nucleic Acid Assessment From Distinct Formulations 9/8/2023

    Review a showcase of a high throughput robust analysis for nucleic acid integrity and size assessment of mRNA-LNP samples using a multi-capillary system and purity and integrity analysis kit.

  8. Molecular Weight Confirmation For Length, Integrity And Impurity Analysis Of A 70-Mer Oligonucleotide 9/8/2023

    Explore a workflow used to determine the molecular weight and analyze the purity of a 70-mer DNA sequence with a 3’ dT overhang.

  9. Structural Characterization Of The Cationic LNP Component 8/31/2023

    Gain a deeper understanding of how EAD is used when characterizing ALC-0315 and its impurities, as well as identify the nature and site of chemical alterations in ALC-0315 resulting from forced degradation.

  10. Characterization And Relative Quantification Of mRNA 5’-Capping 8/31/2023

    Review the development of an LC-MS method for the reliable identification and relative quantification of different mRNA capping structures.