Application Notes & Case Studies

1. Performance Of Novapure® Plungers For Syringes In Autoinjector Systems 8/4/2021

   When moving from vial systems to pre-filled syringes and autoinjector systems, factors to consider include patient and caregiver needs, drug product requirements, system components, and performance.

2. Mixing Efficiencies For The 2,000 L HyPerforma Single-Use Mixer 8/3/2021

   In this application note we demonstrate the mixing capabilities of the Thermo Scientific™ 2,000 L HyPerforma™ Single-Use Mixer (S.U.M.) for various applications and to determine optimal mixing parameters. Five different mixing studies were performed to show how the 2,000 L HyPerforma S.U.M. performs complete, rapid mixing that can be used in a variety of large-scale upstream and downstream processes that contain a wide variety of materials, ranging from liquids, floating solids, sinking solids, and viscous liquids.

3. Saving Development Time And Economizing Distribution With A Single-Vendor Approach 7/29/2021

   By minimizing the overall time, complexity, and effort of clients’ projects and reducing the risks, Thermo Fisher’s most complete integrated offering represents a strong single-vendor solution.

4. Lymphoma Mouse Model—A20, Testing For New Immunotherapies In Oncology 7/27/2021

   One of the most encouraging areas of research for emerging new therapeutics is immunotherapy. In this study, the A20 cell line was derived from a B lymphocyte reticulum cell sarcoma originally isolated from an old BALB/c mouse.

5. Virus Filtration Assurance Through Automation 7/8/2021

   Learn how to achieve virus filtration assurance with a purpose-built automation software that integrates our filtration expertise into your manufacturing suite at every step of the process.

6. One-Step Isolation And Activation Of Naive And Early Memory T Cells With CTS Dynabeads CD3/CD28 7/6/2021

   In this application note we demonstrate nearly 100% recovery of naive and early memory T cells using Gibco™ CTS™ Dynabeads™ CD3/CD28 beads. This one-step process of simultaneous T cell isolation and activation yields pure and uniformly activated T cells.

7. Identifying The Decision-Makers At Your Customers’ Organizations 6/29/2021

   ISR was engaged by the Global Marketing Director at a Top 20 CDMO with the above question. The client had years of experience in marketing their brand to prospective customers but had recently begun to question the efficiency of their marketing spend. The client wanted to demonstrate to their company stakeholders that their marketing efforts were not only hitting the right targets, but that the language used in those efforts reflected their customers’ needs. Knowing this information would allow the client’s marketing department to move away from broad, product-based messaging focused on how good their services are, to messaging focused on how their services address their customers’ concerns.

8. Pharmaceutical Company Successful Scale Up From Trial Stage Lab Mixer To Industrialized Process 6/22/2021

   A multinational pharmaceutical company was developing a modified virus to be used in treatment to destroy cancerous tumors. To do this they needed equipment that could finely disintegrate and disperse the materials needed to produce the virus. After a successful trial of a lab mixer at the first stage of process development they worked with a manufacturer to purchase UHS autoclavable design mixers to get the same successful results at a larger scale.

9. Nitrogen Purging Process Development For Oxygen Sensitive Formulations In Pre-Filled Syringes 6/22/2021

   A new biological product, in pre-filled glass syringes, had demonstrated oxygen sensitivity in stability studies. Therefore, the headspace was purged with nitrogen during filling, and the client wanted to validate the batch production process and assess the nitrogen purge efficiency. In this study we demonstrate by performing a 100% inspection on the engineering batches using non-destructive headspace oxygen analysis you could gather the data needed before a commercial launch.

10. Targeting Once Inaccessible Phospho-Proteins With RePlex 6/17/2021

    Vividion Therapeutics is a small molecule company harnessing its expertise in target biology, chemistry, and mass spectrometry to transform the future of human health. They were frustrated with their process when monitoring quantitative phospho-protein changes as it was notoriously problematic and slow. By transferring their assays over to Simple Western™ with Jess™ combined with Jess’ RePlex™ module they are able to increase throughput and improve the accuracy of his phospho-protein quantification.