Application Notes & Case Studies

1. Multidimensional Scale-Up Of A Monoclonal Antibody Capture Step Contributes To Shortened Time To Market
   10/10/2018

   Fast and efficient process development and scale-up contributes to a shortened time to market. This application note demonstrates a multidimensional scale-up (change of both column diameter and bed height) of a mAb capture step, using the ÄKTA pilot 600 chromatography system.

2. Process-Economy Simulation Of mAb Capture Step With Protein A Chromatography Resin
   10/10/2018

   Calculation examples that highlight scenarios where the enhanced capacity and alkaline‑stability of MabSelect PrismA can provide process economic benefits to large‑scale mAb processing.

3. Replace Dye Ingress With Mass Extraction To Mitigate Risks
   10/2/2018

   A major pharma company had a problem. Its manufacturing process engineers could not reliably verify that pouch packages were sealed properly. Product could potentially ship with questionable packaging.

4. Use Of Sodium Hydroxide For Cleaning And Sanitization Of Chromatography Resins And Systems
   10/2/2018

   This application note examines these aspects of using sodium hydroxide as a cleaning and sanitizing agent.

5. Lifetime Performance Study Of MabSelect™ PrismA During Repeated Cleaning‑In‑Place Cycles
   10/2/2018

   A demonstration of the long‑term chromatographic performance of MabSelect PrismA during repeated purification cycles using 0.5 M NaOH for CIP.

6. Capacity And Performance Of MabSelect™ PrismA Protein A Chromatography Resin
   10/2/2018

   This application note demonstrates the binding capacity of MabSelect PrismA in comparison with its predecessor products for both polyclonal and monoclonal antibodies.

7. S.U.B. Enhancements For High-Density Perfusion Cultures
   9/20/2018

   This study presents how strategic enhancements to the sparge and agitation systems of Thermo Scientific™ HyPerforma™ S.U.B.s have revealed the potential for a three- to four-fold improvement in mixing and mass transfer performance compared to legacy S.U.B. designs.

8. Mass Transfer Of Single-Use Fermenters To Stirred Glass Bioreactors
   9/20/2018

   The aggressive performance demands of industrial microbiology have limited the conversion of traditional fermentation processes into single-use systems. In order to address the unique needs of microbial applications, single-use fermentors have been designed to meet the requirements of microbial fermentation instead of being modified from a cell culture bioreactor.

9. Scale-up And Tech Transfer From 100 L SIP/CIP Vessel To The 300 L S.U.F.
   9/20/2018

   A collaborative study with a new customer with the objective of taking an existing, smaller preclinical E. coli process previously performed in stainless steel vessels and scaling it up quickly using the Thermo Scientific™ HyPerforma™ 300 L Single-Use Fermentor (S.U.F.)

10. Total Transportation Management Saves Company $10.2 Million
    9/20/2018

    A leading multinational pharmaceutical company approached Fisher Clinical Services with an extensive clinical trial pipeline and the need to achieve a comprehensive, fully-managed transportation strategy. Learn more about our outsourced transportation option that delivered tangible results.