Application Notes & Case Studies
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High Sequence Coverage And Confident PTM Analysis Of Biotherapeutics Using An EAD-Based Workflow
9/21/2023
Explore how a streamlined, EAD-based middle-down workflow can achieve consistent high sequence coverages of mAb subunits and confident PTM analysis in a single injection.
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Monitoring And Determining The Cause Of Antibody Discoloration Using cIEF And EAD
9/21/2023
View a study which provides additional insight into the factors that govern the discoloration of protein therapeutics and the role of AGEs in color change.
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EAD-Based Middle-Down Workflow Analysis
9/21/2023
How can a single-injection, EAD-based middle-down workflow leverage accurate mass measurement, information-rich EAD fragmentation and automated data analysis to offer confident sequence confirmation.
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CE-SDS Analysis Of Etanercept Using The BioPhase 8800 System
9/21/2023
In this study, a system with multi-capillary capabilities was used to analyze etanercept by bapillary electrophoresis-sodium dodecyl sulfate (CE-SDS).
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CAPA Management Improvement Process
9/15/2023
Gain insight into how a small team of experts worked to collect, trend, and understand the CAPA generation and completion process of a client struggling with on-time batch release, missed CAPA closure deadlines, and more.
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Accurate HC-LC Pairing And A Close-To-Nature Solution For bsAbs
9/11/2023
Examine how a proprietary technology ensures high levels of accurate HC-LC pairing without detriment to critical quality attributes such as titer, binding affinity, stability, and immunogenicity.
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mRNA-LNP Nucleic Acid Assessment From Distinct Formulations
9/8/2023
Review a showcase of a high throughput robust analysis for nucleic acid integrity and size assessment of mRNA-LNP samples using a multi-capillary system and purity and integrity analysis kit.
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Molecular Weight Confirmation For Length, Integrity And Impurity Analysis Of A 70-Mer Oligonucleotide
9/8/2023
Explore a workflow used to determine the molecular weight and analyze the purity of a 70-mer DNA sequence with a 3’ dT overhang.
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Structural Characterization Of The Cationic LNP Component
8/31/2023
Gain a deeper understanding of how EAD is used when characterizing ALC-0315 and its impurities, as well as identify the nature and site of chemical alterations in ALC-0315 resulting from forced degradation.
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Characterization And Relative Quantification Of mRNA 5’-Capping
8/31/2023
Review the development of an LC-MS method for the reliable identification and relative quantification of different mRNA capping structures.