INSIGHTS ON PHARMACEUTICAL PRODUCTION

• CMC Strategies For A Bispecific Antibody Platform For Cancer Immunotherapy

  Bispecific antibody development presents many challenges in product expression, bispecific purification, product stability, and scale up of the manufacturing process. 

• Cell Growth Performance In Single-Use Bags

  Achieving consistent cell growth is critically important to the biotech industry. To optimize the final drug product output the current industry trends are towards higher cell densities and protein titers.

• Track-And-Trace In The Drug Supply Chain

  Though the timelines may vary, across the globe more and more countries are requiring product identifiers and serialization of prescription drugs — right down to individual salable units. 

• Particle Size Analysis For The Pharmaceutical Industry

  Product effectiveness and production processes are influenced by particle size. Look at particle size and distribution of three lactose powders destined as an excipient for different pharma applications.

• Reshoring A Nation’s API And Pharmaceutical Production

  The pharmaceutical industry has embraced a global supply chain model for decades, seeking cost advantages made available by offshore manufacturing of starting materials, intermediates, and active pharmaceutical ingredients (APIs), particularly in Asia. However, a variety of concerns –– notably underscored by supply chain disruptions driven by the COVID-19 pandemic –– are pushing companies to redraw their global supply chains to resume more domestic manufacturing, aided by new technologies and equipment that can reduce costs.

• Virus Reduction Of An Affinity Capture Step: Viral Clearance For Protein A

  Learn more about how HiScale 10/40, packed with MabSelect PrismA, is a reliable choice for the capture step in a virus clearance study.

• Can You Afford Not To Outsource Buffer Preparation?

  The decision whether or not to outsource buffer preparation is not clear-cut, but provides an opportunity to balance risk with reward. This column examines the benefits of outsourcing.

• Evolving Containment In Pharma Manufacturing Facilities

  Pharmaceutical manufacturing is now undergoing significant transformation. COVID-19 and its pressure on nearly every aspect of human life has put a gigantic emphasis on rapid development of prescriptives, vaccines, and accelerated means for pharmaceutical mass-production. This paper characterizes the new production directions in pharmacy and describes flexible equipment to improve pharma efficiency, purity, and production safety in the coming decade.

• Addressing New Chromatography Challenges With Fiber Absorbents

  An absorbent material using a novel proprietary structure overcomes the diffusional and flow limitations of packed bed chromatography purification systems and aims to address the capacity issues.