INSIGHTS ON PHARMACEUTICAL PRODUCTION
Optimize Scale-Up And Increase Capacity For Vaccine And Therapeutic Manufacturing
In order to accelerate development and manufacturing in the era of SARS-CoV-2, companies are designing scale-up processes in parallel with Phase III clinical trials, redefining the risk tolerance for everyone involved. Read this article to consider a new way of doing business by reviewing existing capabilities, assessing risk tolerance, and identifying key resources to accomplish your goals.
Thermo Fisher Scientific EMEA Single-Use Technologies Capacity Expansion
Thermo Fisher Scientific is expanding our single-use manufacturing network globally. Our Cramlington, UK site has expanded clean room space and invested in chamber manufacturing equipment for our BioProcess Containers and fluid transfer assemblies. Quality systems and processes have also been harmonized with other single-use manufacturing sites to provide true manufacturing redundancy for our customers.
Security Of Supply In Cell And Gene Therapy Manufacturing
With so many challenges in cell and gene therapy manufacturing, building an adequate supply chain with the necessary equipment and protocols is critical for companies pursuing these life-saving drugs.
Cultivation Of Sf9 Insect Cells And rSEAP Expression
This application note describes the cultivation of Sf9 suspension cells in the Thermo Scientific HyPerforma Rocker Bioreactor with a maximum working volume of 5.0 L.
Mixing And Blending Recommendations For Sterile Ingredients
Products manufactured under sterile or cleanroom conditions - for example injectables and vaccines - present different challenges, especially regarding product sterilization. For these products, mixing would normally take place before sterilization but there are instances where post-production sterilization is impossible for technical reasons, placing further restrictions on the mixing process.
Fast And Effective Digital Transformation
We identify common challenges when deploying traditional customized solutions, contrast that with the benefits of an out-of-the-box approach, and cover the critical role of change management.
Mixing And Blending Strategies For Emulsified Vaccines
To produce a stable W/O emulsified vaccine with maintained immunity-inducing properties, the manufacturing process must achieve small emulsion droplets (<1 µm) with a monomodal and narrow particle size distribution. The use of high shear energy provided by a rotor/stator mixer is required to reach this target.
Why A Modular Continuous Pilot Plant Might Be Your Flow Chemistry Solution
There are still very few companies that have been able to successfully scale-up an API or intermediate with one or more continuous chemical process steps beyond the kilogram range under cGMP conditions. The best option to overcome the limitations in capital costs and timelines is known as a Modular Continuous Pilot (MCP) plant.
A New Way Of Looking At De-Nesting And Re-Nesting Solutions
The emphasis for designing and manufacturing systems to handle drug container is on container integrity and gentle handling to prevent breakages and product losses. We have developed the innovative, automatic handling unit Nestor to process ready-to-use containers, such as syringes, to and from nests and tubs.
PHARMACEUTICAL PRODUCTION SOLUTIONS
Used IMA High Speed Pharmaceutical Checkweigher – Precisa 120
Used IMA capsule checkweigher, model Precisa 120, designed to handle hard gelatine capsules, rated up to 120,000 capsules/hour, capsule size range from 40 mg to 2000 mg, +/- 2 mg accuracy, serial# PA1031, built 1999.
Prefilled Syringe Manufacturing Brochure
AbbVie Contract Manufacturing offers development to commercial manufacturing services for prefilled syringes at our Barceloneta and Lake County facilities. Barceloneta is one of the world’s most advanced facilities for biologics syringe filling and Lake County has broad packaging services from blister packs to auto-injectors.
Protein Design And Process Development
Grifols excels in expressing complex, challenging proteins that don’t fit into a predefined program. Our scientists are creative and innovative applying new techniques to solve problems of yield, protein folding, purity, and more. The best projects are those that have never been done before and have the potential to change the view of medicine or manufacturing.
Scott Turbon High Shear Mixers Brochure
Scott Turbon manufactures high-performance, long-lasting stainless steel high shear mixers for use in the food, cosmetic, biopharmaceutical, and chemical industries.
Hot Melt Extrusion Pharmaceutical Formulation Brochure
AbbVie Contract Manufacturing offers proprietary hot melt extrusion technology in both the US and Europe. Our Ludwigshafen, Germany location offers development and commercial production, while our Barceloneta, Puerto Rico facility offers further commercial production capabilities. Hot melt extrusion is a robust process that offers continuous processing capabilities for a more economical manufacturing method serving poorly-soluble APIs, potent APIs, abuse deterrence, taste masking, and solvent-free formulations.