INSIGHTS ON DRUG DEVELOPMENT

• Technical Considerations For Developing Oral Solids (Part 2)

  What technical considerations should be at the forefront for your oral solids project? This two-part series features four oral solids experts from Pfizer CentreOne’s global network and partner organizations discussing the technical considerations to be aware of. In the second installment of the series, our experts consider the effects of equipment design and different tablet strategies.

• Technical Considerations For Developing Oral Solids (Part 1)

  Navigating your oral solids project from development through commercial manufacture can be a challenging path. In a two-part series, four oral solids experts from Pfizer CentreOne’s global network and partner organizations discuss the technical considerations to be aware of. In this first installment, we look at the importance of technical groundwork and understanding excipients in the early stages of your project.

• Enhanced Host Cell Protein Analysis In Biologics Manufacturing

  iEnzyme-Linked Immunosorbent Assays (ELISAs) to monitor host cell protein levels are challenging. This article illustrates an enhanced anti-host cell protein antibody coverage analysis method solution.

• Expanding SPR Uses In Antibody Effector Function Determination

  To minimize risk and to get “true” affinity in binding analysis, we've adopted the latest innovation in surface plasmon resonance technology to develop and qualify assays for mAbs and other therapeutic proteins.

• Explore Alternative Analytical Methods To Solve Process Challenges

  Successful and rapid analytical method development plays a key role in ensuring the development of robust processes to produce high-quality products. 

• Materials Characterization In Pharma

  Materials science is now helping pharmaceutical companies to standardize and control areas such as drug form and manufacture to deliver new products more quickly and with greater quality.

• Strategies For Optimizing Upstream Processes Cell Culture

  The cell culture process is crucial for maximizing the production of biologics and vaccines, optimizing product quality attributes, minimizing impurities, and simplifying operations.

• In Vitro Test Methodologies To Characterize Bioavailability Enhancing Formulations

  Some of the most important technologies available to formulators are those that enhance bioavailability, given the large percentage of low-solubility compounds in today’s pharmaceutical pipelines. Formulators have many choices in their toolkit when it comes to bioavailability enhancement, so the tough call becomes which one to use for a given compound. Lonza has developed a full complement of tools that accurately predict the performance of bioavailability-enhanced formulations.

• A Roadmap For Early Development To Commercial Manufacturing

  Learn how to avoid common pitfalls in the transfer and scale-up process using an integrated approach, with industry experts sharing key considerations when planning for scale-up of a development program.