INSIGHTS ON DRUG DEVELOPMENT

  • Bayer Evaluates Fibro For Scalable Single-Use mAb Purification

    Learn how Bayer evaluated Fibro PrismA chromatography to determine its potential as a true single-use mAb capture technology. They assessed scalability from lab- to process-scale tracking pressure drop, step recovery, purity, and eluate volumes across multiple cycles. Read the outcome here.

  • Identifying The Best People To Run A Clinical Study (And How To Hire Them)

    No matter how brilliant a clinical trial process or a technology may be, it is useless without skilled, motivated individuals at the helm.  

  • How Can We Predict Immunogenicity Earlier?

    With many biotherapeutics a strong immunogenic response can limit the effectiveness of the treatment or cause a more serious illness. This remains a challenge for scientists as the underlying mechanisms of unwanted immunogenicity still aren’t completely understood. Detecting and preventing unwanted sources of immunogenicity as early in the discovery process as possible has become a top priority for research organizations since biotherapeutic development becomes increasingly costly as it moves downstream.

  • Digital Lab Documentation - Improve Collaboration, Productivity, & Reduce Costs

    Laboratory organizations need an environment that facilitates and optimizes collaboration, experiment execution, documentation and data management in the different labs from R&D through manufacturing to commercialization. By implementing a digital lab solution you can bridge the innovation and productivity gaps in research, development, manufacturing and quality, and enable successful technology transfer across new product development and production operations.

  • Harnessing Data Science And AI For Drug Development Innovation
    5/17/2021

    When it comes to drug discovery and development, employing these technologies has become an existential challenge for the pharmaceutical industry. So how can these technologies help the pharmaceutical companies reduce the staggering expense and amount of time it takes to develop new therapeutics, getting there sooner, with less compounds needing to be tested and proved? AI & Machine Learning (ML) are deployed to explore potential drug candidates faster, able to meet a particular target product profile.

  • Liposomal And Nanoparticle Technology At Pfizer Melbourne
    4/22/2021

    In recent years, liposome technologies have become an important part of the drug delivery armory, with several marketed products now available for use and many more formulations being evaluated in clinical trials.

  • Closed And Semi-Automated Processing Of CAR T-Cells
    7/5/2019

    This application note describes the details of a robust CAR T-cell manufacturing workflow that can be adapted for cGMP compliance in commercial production of CAR T-cells.

  • Best Practices For A Successful Bioprocess Technology Transfer
    9/10/2019

    A well-executed bioprocess technology transfer is critical to ensure smooth knowledge transfer and optimal process reproducibility. 

  • Implementing A Unified Lab Management Solution
    3/31/2021

    With nearly 2,000 scientists and twice as many instruments spread across multiple global locations, the customer was managing eight different electronic notebook (ELN) systems and Laboratory Information Management Systems (LIMS). The customer’s challenge was to unify data collection and management across the different phases of early discovery, R&D, and clinical and commercial manufacturing. By implementing a comprehensive agile framework, the customer and BIOVIA were able to release 3 major and 2 intermediate software iterations within 12 months.

DRUG DEVELOPMENT SOLUTIONS

  • Many researchers are looking to drug repurposing, searching lists of treatments previously approved for other uses by various regulatory bodies, to source novel therapies for current or emerging pathogens quickly. This should ensure resulting treatments are relatively safe, as previous clinical trials have done much of the work to assess toxicity risk. BIOVIA Discovery Studio offers a range of in silico techniques to virtually screen existing candidates for efficacy against viral targets, guiding drug repurposing projects and shortening the time to get treatments to the patients who need them most.

  • AST’s line of table-top machines, GENiSYS® Lab, are ideal systems for drug product development and cGMP production applications. Each system is designed to automate the critical aseptic operations for vial, syringe and cartridge processing to reduce contamination risk and product variability. These table-top systems are engineered to have complete compatibility with cleanroom environments, including Laminar Air Flow Hoods, Bio-Safety Cabinets and aseptic isolators.

  • Computational materials science techniques can help researchers gain a deeper understanding of the molecular interactions that underpin the physicochemical properties of a drug and its interactions with excipients and other coformers. BIOVIA Materials Studio offers a comprehensive collection of tools to foster the understanding researchers need to optimize existing formulations, develop new ones or explore completely novel delivery methods.

  • The Crystal Zenith (CZ) polymer addresses the need for a clear, biocompatible material that overcomes problems inherent in glass vials, syringes and cartridges. 

  • The BIOVIA Unified Lab offers research, development, analytical and QA/QC laboratories a unique opportunity to remove paper processes and better support end-to-end analytical and process workflows. Unified, harmonized and standardized laboratory/resource management and procedure execution can help achieve your business goals by improving collaborative innovation, increasing productivity, reducing regulatory compliance and safety risk and accelerating time to market.

    BIOVIA Workbook is a multi-disciplinary electronic lab notebook (ELN) for documenting and managing the flow of information, tasks and materials within and between labs, with authoring and workflow support.

    BIOVIA Notebook, an easy-to-deploy, easy-to-use ELN is for organizations focused on intellectual property capture and information sharing, process documentation and overall lower total cost of ownership.

    BIOVIA CISPro is a chemical inventory management system that makes current, real-time chemical safety and inventory data available on-demand, helping to drive the safe handling, storage and management of chemicals and other inventory materials.