INSIGHTS ON DRUG DEVELOPMENT

• Critical Considerations About The Future Of Global Cell Culture Bioprocessing

  In today’s changing industry, it is critical we consider several factors about cell culture bioprocessing and the impact they will have on the future of patient treatment.

• Lipid Formulations To Enhance Bioavailability In Early Development

  To prevent delays and costly issues during molecular development, it is important to understand potential mechanisms of increased absorption with lipid formulations and the appropriate screening tools.

• Why Are Lipid Formulations Commonly Used To Enhance Bioavailability?

  A discussion on potential mechanisms of increased absorption with lipid formulations, screening tools used during the development of these formulations, scale up, and industrialization considerations. 

• Explore Alternative Analytical Methods To Solve Process Challenges

  Successful and rapid analytical method development plays a key role in ensuring the development of robust processes to produce high-quality products. 

• How Extrusion-Spheronization Can Help To Control Delivery And Enhance Performance Of Complex Therapies

  In this blog, we explore why and how the technique of extrusion-spheronization offers pharmaceutical companies a robust, proven way to manufacture today’s most complex therapies. We also discuss the key considerations for drug developers who are looking to select a contract manufacturer as a partner to deliver this technique.

• Closed And Semi-Automated Processing Of CAR T-Cells

  This application note describes the details of a robust CAR T-cell manufacturing workflow that can be adapted for cGMP compliance in commercial production of CAR T-cells.

• Benefits And Challenges Of Driving Modernization In Vaccine Development

  Protein Sciences learned several valuable lessons during the development and final regulatory approval of its recombinant hemagglutinin (rHA) influenza vaccine, Flublok.

• Optimizing Process Efficiency In Upstream Manufacturing

  Increasing the integration of upstream and downstream processing and moving toward increased automation results in greater optimization of process efficiency — a key goal for biopharma production.

• An Engineered Platform For High-Loaded Dosage Forms Of Amorphous Solid Dispersions

  This poster outlines a novel engineered platform for the formulation of high-active-loading oral solid dosage forms containing amorphous solid dispersions (ASDs) of a rapidly crystallizing drug with a low glass-transition temperature (Tg).