INSIGHTS ON DRUG DEVELOPMENT
Critical Considerations About The Future Of Global Cell Culture Bioprocessing
In today’s changing industry, it is critical we consider several factors about cell culture bioprocessing and the impact they will have on the future of patient treatment.
Lipid Formulations To Enhance Bioavailability In Early Development
To prevent delays and costly issues during molecular development, it is important to understand potential mechanisms of increased absorption with lipid formulations and the appropriate screening tools.
Why Are Lipid Formulations Commonly Used To Enhance Bioavailability?
A discussion on potential mechanisms of increased absorption with lipid formulations, screening tools used during the development of these formulations, scale up, and industrialization considerations.
Explore Alternative Analytical Methods To Solve Process Challenges
Successful and rapid analytical method development plays a key role in ensuring the development of robust processes to produce high-quality products.
How Extrusion-Spheronization Can Help To Control Delivery And Enhance Performance Of Complex Therapies
In this blog, we explore why and how the technique of extrusion-spheronization offers pharmaceutical companies a robust, proven way to manufacture today’s most complex therapies. We also discuss the key considerations for drug developers who are looking to select a contract manufacturer as a partner to deliver this technique.
Closed And Semi-Automated Processing Of CAR T-Cells
This application note describes the details of a robust CAR T-cell manufacturing workflow that can be adapted for cGMP compliance in commercial production of CAR T-cells.
Benefits And Challenges Of Driving Modernization In Vaccine Development
Protein Sciences learned several valuable lessons during the development and final regulatory approval of its recombinant hemagglutinin (rHA) influenza vaccine, Flublok.
Optimizing Process Efficiency In Upstream Manufacturing
Increasing the integration of upstream and downstream processing and moving toward increased automation results in greater optimization of process efficiency — a key goal for biopharma production.
An Engineered Platform For High-Loaded Dosage Forms Of Amorphous Solid Dispersions
This poster outlines a novel engineered platform for the formulation of high-active-loading oral solid dosage forms containing amorphous solid dispersions (ASDs) of a rapidly crystallizing drug with a low glass-transition temperature (Tg).
DRUG DEVELOPMENT SOLUTIONS
Ultracentrifuge With Rotor Life Management (RLM) System
The CP100WX is a general-purpose Ultracentrifuge with outstanding performance up to 100,000 rpm assisting in a wide range of separation protocols in involving proteins, DNA, RNA, metal nano-colloids, and more.
DPI Formulation Development And Manufacturing
The respiratory system provides an attractive drug-absorption target to treat local and systemic diseases and is increasingly used to deliver small molecules and biotherapeutics. As described in this technical brief, Lonza has extensive experience in formulation development and manufacturing of respiratory drug-delivery products from proof of concept (POC) to manufacturing of dry-powder inhaled (DPI) formulations. Our technical brief provides additional information.
Mammalian Cell Culture: Process R&D Services
Lonza’s global R&D center for mammalian cell processes is based in Slough, UK alongside a custom manufacturing facility. Lonza undertakes highly specialized development and manufacturing services for the pharmaceutical and biotechnology industries. Read more about Lonza’s complete range of R&D Services and an array of technologies and skills to best match their customers’ requirements for all stages of product development.
Pharmaceutical Bench-Top Filling & Closing Machines: GENiSYS® Lab
AST’s line of table-top machines, GENiSYS® Lab, are ideal systems for drug product development and cGMP production applications. Each system is designed to automate the critical aseptic operations for vial, syringe and cartridge processing to reduce contamination risk and product variability. These table-top systems are engineered to have complete compatibility with cleanroom environments, including Laminar Air Flow Hoods, Bio-Safety Cabinets and aseptic isolators.
Container Closure Integrity Testing
Successful drug product development should integrate formulation, manufacturing process, primary packaging, device and delivery to the patient. Lonza’s Drug Product Services (DPS) offering delivers a holistic approach to DP development that anticipates and prevents problems early, and ensures the result is a product that is fit for purpose.