INSIGHTS ON DRUG DEVELOPMENT

• Bayer Evaluates Fibro For Scalable Single-Use mAb Purification

  Learn how Bayer evaluated Fibro PrismA chromatography to determine its potential as a true single-use mAb capture technology. They assessed scalability from lab- to process-scale tracking pressure drop, step recovery, purity, and eluate volumes across multiple cycles. Read the outcome here.

• Identifying The Best People To Run A Clinical Study (And How To Hire Them)

  No matter how brilliant a clinical trial process or a technology may be, it is useless without skilled, motivated individuals at the helm.  

• How Can We Predict Immunogenicity Earlier?

  With many biotherapeutics a strong immunogenic response can limit the effectiveness of the treatment or cause a more serious illness. This remains a challenge for scientists as the underlying mechanisms of unwanted immunogenicity still aren’t completely understood. Detecting and preventing unwanted sources of immunogenicity as early in the discovery process as possible has become a top priority for research organizations since biotherapeutic development becomes increasingly costly as it moves downstream.

• Digital Lab Documentation - Improve Collaboration, Productivity, & Reduce Costs

  Laboratory organizations need an environment that facilitates and optimizes collaboration, experiment execution, documentation and data management in the different labs from R&D through manufacturing to commercialization. By implementing a digital lab solution you can bridge the innovation and productivity gaps in research, development, manufacturing and quality, and enable successful technology transfer across new product development and production operations.

• Harnessing Data Science And AI For Drug Development Innovation

  5/17/2021

  When it comes to drug discovery and development, employing these technologies has become an existential challenge for the pharmaceutical industry. So how can these technologies help the pharmaceutical companies reduce the staggering expense and amount of time it takes to develop new therapeutics, getting there sooner, with less compounds needing to be tested and proved? AI & Machine Learning (ML) are deployed to explore potential drug candidates faster, able to meet a particular target product profile.

• Liposomal And Nanoparticle Technology At Pfizer Melbourne

  4/22/2021

  In recent years, liposome technologies have become an important part of the drug delivery armory, with several marketed products now available for use and many more formulations being evaluated in clinical trials.

• Closed And Semi-Automated Processing Of CAR T-Cells

  7/5/2019

  This application note describes the details of a robust CAR T-cell manufacturing workflow that can be adapted for cGMP compliance in commercial production of CAR T-cells.

• Best Practices For A Successful Bioprocess Technology Transfer

  9/10/2019

  A well-executed bioprocess technology transfer is critical to ensure smooth knowledge transfer and optimal process reproducibility. 

• Implementing A Unified Lab Management Solution

  3/31/2021

  With nearly 2,000 scientists and twice as many instruments spread across multiple global locations, the customer was managing eight different electronic notebook (ELN) systems and Laboratory Information Management Systems (LIMS). The customer’s challenge was to unify data collection and management across the different phases of early discovery, R&D, and clinical and commercial manufacturing. By implementing a comprehensive agile framework, the customer and BIOVIA were able to release 3 major and 2 intermediate software iterations within 12 months.