White Paper

Topliss Sets In Drug Design Technical Notes For The Medicinal Chemist

GettyImages-1421547005 doctor writing

Medicinal chemists may spend years designing and synthesizing thousands of analogues of an initial hit to optimize not only the fundamental interaction of the molecule with the biological target but also the distribution, metabolism and pharmacokinetic profiles of the drug. The length of the process ultimately has a major impact on drug development costs, and any stratagem that can help drive the design process to completion in a shorter time is highly desirable.

When considering new, innovative, and efficient drug design processes, you may want to review Professor J G Topliss's non-mathematical operational schemes for analogue design.

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