Success Story: N-1 Perfusion High Inoculum Fed-Batch For Reduced COGS And Easy Retrofit

A mid-to-large-sized biopharmaceutical company sought to significantly enhance the efficiency of its fed-batch manufacturing operations, aiming to boost productivity by two to three times while simultaneously reducing its cost of goods sold (COGS). These ambitious goals were driven by the need to remain competitive and meet increasing market demands without expanding infrastructure or incurring substantial new costs. Remarkably, the company achieved these targets through a relatively minor yet strategic adjustment in its upstream (USP) seed train process. This single change streamlined the early stages of cell culture development, which led to more robust and consistent production runs. Discover how the company not only met its productivity and cost-reduction objectives but also demonstrated how targeted process optimization can yield substantial operational benefits without the need for large-scale overhauls.