Solubility Enhancement Via Amorphous Solid Dispersions: Extended Functionality By Applying A Versatile Polyvinyl Alcohol Platform For Hot Melt Extrusion

By Nicole Di Gallo, Alessandro Giuseppe Elia, Nabil Lamrabet, and Thomas Kipping

Investigate the potential of polyvinyl alcohol (PVA) as a versatile polymer platform for enhancing solubility through hot melt extrusion (HME) in the formulation of amorphous solid dispersions (ASDs) in this study. The research aims to establish a comprehensive PVA polymer framework while elucidating how the molecular structure of PVA influences the efficacy of these dispersions. Utilizing advanced methodologies such as melt rheology, dissolution testing, and differential scanning calorimetry (DSC), critical insights into the impact of hydrolysis degree on the processing parameters of PVA is revealed. The findings underscore the significance of PVA's amphiphilic structure in enhancing solubility across various media. Find out how two PVA grades, Parteck® MXP 3-82 and Parteck® MXP 4-88, showcase their unique rheological behaviors and superior dissolution performance for challenging active pharmaceutical ingredients.

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