Insights On Liquid Dose Manufacturing

1. Enablement Of Patient Centric Solutions Through Integrated Drug-Device Development 2/20/2020

   Development of patient-centric solutions which integrate the appropriate drug product profile and meet delivery system user requirements provides the challenge of combining two distinct development processes. This poster outlines a strategy for this approach.

2. Rapid, Serum-Free, High-Yield Antibody Production In PETG Roller Bottles 4/13/2018

   A rapid, flexible, and high-yield approach for both hybridoma expansion and for antibody production using a serum-free medium in Nunc PETG Roller Bottles.

3. 8 Key Factors When Selecting A Powered Air-Purifying Respirator System 6/27/2019

   This white paper explores eight considerations in detail and could be helpful to EHS managers and supervisors looking to select a Powered Air-Purifying Respirator system for their particular application.

4. Scale-Up And Tech Transfer From 100 L SIP/CIP Vessel To The 300 L S.U.F. 9/20/2018

   A collaborative study with a new customer with the objective of taking an existing, smaller preclinical E. coli process previously performed in stainless-steel vessels and scaling it up quickly.

5. Pfizer Installs Feeding Systems For Continuous Manufacturing Operations 4/10/2019

   Compact arrangement of pharmaceutical feeders supplied by Coperion K-Tron accurately deliver ingredients into the continuous mixing process, guaranteeing consistent and high quality end products.

6. Roller Bottles That Excel With ST, Vero, And MDBK Cells 4/13/2018

   A study was conducted to compare the performance of Thermo Scientific Nunc Roller Bottles (1.2 and 2.5X) and 850 cm2 roller bottles from another supplier, for the culturing of ST, Vero, and MDBK cells.

7. In-Process Monitoring Of Headspace Oxygen Levels In Parenteral Containers 12/27/2018

   Using a high sensitivity detection technique known as Frequency Modulation Spectroscopy (FMS), LIGHTHOUSE rapid non-destructive headspace oxygen inspection can help streamline the monitoring of purge performance on the filling line. This paper demonstrates the correlation of the FMS rapid non-destructive technique for analyzing headspace oxygen levels with the most commonly used conventional destructive techniques for headspace oxygen inspection.

8. Oxygen Permeation In Pre-Filled Syringes 1/2/2019

   This webinar presents how to design and conduct studies to assess the total oxygen permeation rate of your pre-filled syringes, and how to determine if the permeation is primarily through the plunger or through the tip.  Protecting oxygen-sensitive formulations during filling will also be discussed. 

9. Implementing FDA Guidance: CCI Testing In Lieu Of Sterility Testing 12/26/2018

   This application note details FDA released guidance titled “Container and Closure System Integrity Testing in Lieu of Sterility Testing as a Component of the Stability Protocol for Sterile Products."

10. Avoiding Hemolysis Blood Sample Collection Processing 2/11/2019

    Erythrocytes have significant value in specific types of research. If your objective is biobanking these cells in an intact state then it is equally important that hemolysis and the need for a re-draw is avoided. This paper explains how hemolysis can be prevented during specimen collection and handling.