DIOSNA Compact Granulation System CGS

The Diosna CGS (Compact Granulation System) is state of the art granulation production in the world's most compact, flexible and integrated plant.

Wet granulation of pharmaceutical tablet mixtures with subsequent fluid bed drying is a basic step in the production of solid dosage forms. The CGS(Compact Granulation System)concept provides optimal integration of the process steps of mixing, granulating and drying. The outlet of the mixer-granulator is directly linked to the inlet of the fluid bed dryer, eliminating long transfer chutes. Thus product contact surfaces are minimised and the yield is increased. Even sticky granules which are difficult to transport by pneumatic conveying can be transferred easily and quickly into the dryer.

The CGS (Compact Granulation System) design advantage is in close coupling technology developed by Diosna, which reduces the transfer distances between all processes while optimizing each of those processes though various techniques. The results speak for themselves: higher product yields, easiest access for inspection and cleaning, smallest installation in process room, improved GMPs throughout process train and simplified process. Validation though one highly integrated 21 CFR Part 11 control system.

Compact Granulation System (CGS) Benefits:

• Dry mixing/wet granulating/hot melt granulating/vacuum drying (with gas stripping aka "one pot processing"),
• Wet calibrating of product (milling) using quadro comil or similar conical screen mill,
• Fluid bed drying/top spray granulating/bottom or tangential spray granulating / wurster coating,
• Dry milling (employing whatever mill is required by your process, generally quadro comil is used),
• Bin blending/drum blending /v-blending with optional integrated weighing system in blender (no floor scale required),
• High containment to ~400 nano-gram (ETWA) throughout system from initial loading of granulator to final transfer to bin/drum/v-shell.