Case Study

A Better Route For Commercial Manufacture: Improved Yields And Operability

Source: Asymchem

Early development routes are often unsuitable for large scale commercial manufacture. A new chemical process improved yields and operability.

Challenge

A new process was needed for the commercial manufacturing of Ceralasertib, an experimental anti-cancer therapy with a challenging molecular structure comprised of a pyrimidine core decorated with a chiral morpholine, a cyclopropyl sulfoximine and an axaindote.

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