A Carrier For Liquid Drug Solubilizers In Solid Dosage Form Pharmaceuticals

The solubility of poorly soluble drugs can be increased by using solubilizers such as polyethylene glycols (PEG), Tween 80 etc. These solublizers can be used to increase oral bioavailability of Class II and Class IV drugs. Often, these solubilizers are liquid in nature and can be challenging to formulate into solid dosage forms such as tablets and capsules. To address this, soft gelatin capsules have been used to deliver liquids. However, higher manufacturing time, poor yields, and more required resources make soft gelatin capsules very costly.

SYLOID® XDP silicas are mesoporous, amorphous, silica gels with a unique morphology that create an excellent solid porous carrier for pharmaceutical formulations. The combined adsorption capacity, porosity, particle size, and density provide a tool to convert liquid ingredients into free flowing powder.