A Clinical Assessment Of Delayed-Release Coated Capsule Compositions For Regional Gastrointestinal Delivery Using Gamma Scintigraphy

Applied Molecular Transport Inc. are evaluating targeted drug delivery capsules for administration of locally acting drugs directly to the site of action in the gastrointestinal (GI) tract. This study used gamma scintigraphy to evaluate GI transit and release from 3 capsule prototypes with different coating systems (1). In addition, data on pH, temperature and pressure during GI transit was obtained using SmartPill^® and correlated with scintigraphy data (2).