Achieving Full Control Over A Binary Blend Feeding A Liquid Chromatography Process Part 1

By Cory Hinz, Engineering Manager, Asahi Kasei Bioprocess America, Inc.

Liquid chromatography processes often require the blending of constituents to create mobile phase solutions, and inline blending using control valves with equal percentage trim is a more efficient approach. This method involves two control valves with distinct roles: the first valve manages the diluent, ensuring optimal blending pressure, while the second valve controls the component being diluted by adjusting flow rates or conductivity. These valves operate independently but respond to each other, allowing for precise control of binary blends in liquid chromatography. This approach serves as the initial step toward achieving full control in this process, with further details to be provided in a subsequent piece.